Some Routine Laboratory Measurements And Antibiotic Choice As Potential Predictors of Mortality in The Pediatric İntensive Care Unit: A Cross-Sectional Study

Year 2019, Volume: 7 Issue: Ek - IRUPEC 2019 Kongresi Tam Metin Bildirileri, 305 - 313, 10.12.2019

Feyza İnceköy Girgin

Abstract

White blood cell (WBC), platelet (PLT) count, and CRP are some basic parameters to follow the outcome of patients in intensive care units. This study aimed to evaluate the differences in the outcome of patients related to some routine laboratory measurements and antibiotic preferences.
Methods: The participants of the study consisted of 179 pediatric ICU inpatients with gram-positive culture results. Hospital records covering the years 2016 to 2019 were reviewed. Other than the mortality status, data were collected on age, sex, the presence of fever, culture results, antibiotic preferences, and laboratory parameters such as WBC, PLT, and CRP levels.
Results: The median (IQR) age of the patients was 33.00 (8.00-66.00) months; 109 (60.89%) were boys, while 70 (39.11%) were girls. Of the patients, 90 (50.3%) had positive culture results, 59 (33%) received vancomycin, 31 ‎(17.3%) received teicoplanin, and 34 (18.9%) had a fatal outcome.‎ The cultured organisms were as follows: Staph. spp. (n=56, 31.3%), methicillin-resistant Staph. epidermidis (n=81, 45.3%), Staph. aureus (n=22, 12.3%), Staph. epidermidis (n=15, 8.4%), and methicillin-resistant Staph. aureus (n=5, 2.8%). WBC and PLT levels were higher in survived patients than the deceased ones (p=0.001 and p<0.001‎‎, respectively. There was no significant association of mortality and any of the studied categorical variables (p>0.05).‎
Conclusion: CRP and PLT are useful indicators for the diagnosis of serious bacterial infections and the prediction of the clinical outcome. There is no difference between using vancomycin or teicoplanin concerning mortality in the ICU.

Keywords

WBC, platelet, CRP, pediatric intensive care unit

References

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