Yenidoğan Ve Çocukluk Çağı İnmelerinde Klinik Ve Protrombotik Risk Faktörleri: Bir Retrospektif Araştırma

Year 2019, Volume: 7 Issue: Ek - IRUPEC 2019 Kongresi Tam Metin Bildirileri, 446 - 452, 10.12.2019

Rukiye Ünsal Saç İkbal Ok Bozkaya Ok Bozkaya Abdurrahman Kara

Abstract

AIM: Neonatal and childhood stroke has high morbidity and mortality, associates with co-morbid conditions, it is difficult to diagnose and the treatment is uncertain. We aimed to examine epidemiology and long term outcomes of childhood stroke patients, followed our department.

MATERIALS AND METHODS:
A retrospective study of enrolled pediatric stroke patients at a pediatric hematology department of a Children's Hospital. The disease presentations, prothrombotic risk factors, co-morbid conditions, stroke-related death or neurological deficits of the children followed-up with stroke diagnosis were recorded.

RESULTS:
A total of 115 children (min-max: 0-16.8 years, median age of diagnosis: 2 years, 49.6% girls) were included. Paresis or plegia (56.5%), convulsions (43.5%), and cranial nerve palsies (10.4%) were most common presentations. Co-morbid conditions were common (69%); the most common were infections (22.6%) and congenital cardiac diseases (20.8%). In 47.7% of the patients who presented with paresis or plegia, stroke was diagnosed within 30 days after stroke; the rest was diagnosed later. Among the determined prothrombotic risk factors, elevated homocysteine levels were the most common (27%), followed by factor V G1691A mutations (20%), and elevated lipoprotein (a) (19.1%) levels. Neurological sequel rate was 62.5%. Mortality rate was 2.6%.

CONCLUSIONS:
Childhood stroke is associated with a variety of co-morbid conditions and hereditary and acquired prothrombotic risk factors. Stroke in children has a high sequel rate. We think that, delayed diagnosis and treatment in our study group could be the reason for this result.

Keywords

Child, Stroke, Intracranial embolism and thrombosis

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