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Year 2019, Volume: 7 Issue: Ek - IRUPEC 2019 Kongresi Tam Metin Bildirileri, 539 - 543, 10.12.2019

Abstract

References

  • Kaynaklar 1. Woods CR, Abramson JS. The next influenza pandemic: will we be ready to care for our children? J Pediatr 2005;(147)147–155. doi: 10.1016/j.jpeds.2005.04.066. 2. Tellier R. Aerosol transmission of influenza A virus: a review of new studies. JR SocInterface 2009; 6 (Suppl 6): 783-90. doi: 10.1098/rsif.2009.0302 focus. Epub 2009 Sep 22. 3. Gelber SE, Ratner AJ. Hospital-acquired viral pathogens in the neonatal intensive care unit. Semin Perinatol 2002;(26)346–356. doi: 10.1053/sper.2002.36268. 4. Whitley RJ, Monto AS (2006). Prevention and treatment of influenzain high-risk groups: Children, pregnant women, immunocompromised hosts, and nursing home residents. J Infect Dis 2006, 194(Suppl 2):133–138. doi: 10.1086/507548. 5. Principi N, Esposito S. (2004). Are we ready for universal influenza vaccination in paediatrics? Lancet Infect Dis 2004(4)75–83. doi: 10.1016/S1473-3099(04)00926-0. 6. Milupi M, Madeo M, Brooke N, Ahmad SJ. Neonatal influenza A/H1N1/2009 outbreak in a UK district general hospital. J Hosp Infect 2012(81)131–133. doi: 10.1016/j.jhin.2012.04.005. 7. Tsagris V, Nika A, Kyriakou D, et al. Influenza A/H1N1/2009 outbreak in a neonatal intensive care unit. J Hosp Infect 2012(81)36–40. doi: 10.1016/j.jhin.2012. 02.009. 8. Rocha G, Pissarra S, Silva G, Guimares H. Experience with oseltamivir in term and preterm newborns. Res. Gate 2010(5)327–331. doi: 10.3233/JPI-2010-0270. 9. Pannaraj PS, Tam B, Akan D. Oseltamivir treatment and prophylaxis in a neonatal intensive care unit during a 2009 H1N1 influenza outbreak. J Perinatol 2011(31)487–493. doi: 10.1038/jp.2010.159. 10. Vij NK, Stryker CC, Esper FP, et al. Influenza A/H1N1/09-10 infections in a NICU during the 2009- 2010 H1N1 pandemic. Pediatrics 2011(128)1297–1301. doi: 10.1542/peds. 2011-0219. 11. Jajoo M, Gupta R. H1N1 influenza in a preterm neonate. Indian J Pediatr 2010(77)1045–1046. doi: 10.1007/s12098-010-0166-2. 12. Bhat N, Wright JG, Broder, KR, et al. Influenza-associated deaths among children in the united states, 2003-2004. N Engl J Med 2005(353)2559–2567. doi: 10.1056/NEJMoa051721. 13. https://www.cdc.gov/flu/professionals/diagnosis/overview-testing-methods.htm. 14. Kimberlin DW, Acosta EP, Prichard MN et al. Oseltamivir pharmacokinetics, dosing, and resistance among <2 years with influenza. J Infect Dis 2013(5):709-20. doi:10.1093/infdis/jis765. Epub 2012 Dec 10. 15. Ronchi A, Michelow IC, Chapin KC, et al. Viral respiratory tract infections in the neonatal intensive care unit: the virion-i study. J. Pediatr 2014(165)690-6. doi: 10.1016/j.jpeds.2014. 05.054. 16. Coşkun O, Avci IY, Sener K, et al. Relative lymphopenia and monocytosis may be considered as a surrogate marker of pandemic influenza a (H1N1). J Clin Virol 2010(4):388-9. doi.1016/j.jcv.2010.01.007. Epub 2010 Feb 4. 17. Wang N, Liu X, Zhang Y, et al. Hematologic Markers of Influenza A H1N1 for Early Laboratory Diagnosis and Treatment Assessment. LabMedicine 2011(42)607-611. 18. Wooltorton, E. Oseltamivir (Tamiflu) unsafe in infants under 1 year old. CMAJ 2004(170):336. 19. FDA, Issuance letter for Tamiflu , 2009. Available at http://www.fda.gov/downloads/Drugs/DrugSafety/InformationbyDrugClass/UCM153547.pdf Accessed 8 September 2009. 20. Acosta EP, Jester P, Gal P, et al. Oseltamivir dosing for influenza infection in premature neonates. J. Infect Dis 2010(202)563–566. doi: 10.1086/654930. 21. Munoz FM. Influenza virus infection in infancy and early childhood. Paediatr. Respir. Rev 2003(4)99–104. doi: 10.1016/S1526-0542(03)00027-7. 22. Matheson NJ, Harnden AR, Perera R, et al. Neuraminidase inhibitors for preventing and treating influenza in children. Cochrane Database Syst Rev 2004(24):CD002744. doi: 10.1002/14651858.CD002744.pub2.

Yenidoğan Yoğun Bakımda İnfluenza Salgını: İnfluenza Enfeksiyonunun Binbir Yüzü

Year 2019, Volume: 7 Issue: Ek - IRUPEC 2019 Kongresi Tam Metin Bildirileri, 539 - 543, 10.12.2019

Abstract

The purpose of this article is to emphasize the variability of symptoms of influenza virus as a causative agent of nosocomial infection in NICU (neonatal intensive care unit), through description of an outbreak in our unit.
Materials and methods
Symptoms, test results and treatment of neonates are discussed during an outbreak in Okmeydani Training and Research Hospital in 2018 influenza season.

Results
Symptoms showed a wide range, a baby was asympthomatic, another showed characteristic viral respiratory tract illness signs. All the babies had monocytosis. Preterm babies showed neutropenia. All the babies were treated with oseltamivir without any side effects.

Conclusion
In many neonatal intensive care units (NICU), if infants deteriorate, standard approach is usually to evaluate for bacterial sepsis. Viral pathogen as a causative agent is not a part of routine evaluation. However, there has been an increasing number of reports on influenza infections in neonates and descriptions of influenza spread within neonatal units. Symptoms may be variable. Monocytosis and neutropenia in periferic blood smear may be a sign of viral respiratory tract infection

References

  • Kaynaklar 1. Woods CR, Abramson JS. The next influenza pandemic: will we be ready to care for our children? J Pediatr 2005;(147)147–155. doi: 10.1016/j.jpeds.2005.04.066. 2. Tellier R. Aerosol transmission of influenza A virus: a review of new studies. JR SocInterface 2009; 6 (Suppl 6): 783-90. doi: 10.1098/rsif.2009.0302 focus. Epub 2009 Sep 22. 3. Gelber SE, Ratner AJ. Hospital-acquired viral pathogens in the neonatal intensive care unit. Semin Perinatol 2002;(26)346–356. doi: 10.1053/sper.2002.36268. 4. Whitley RJ, Monto AS (2006). Prevention and treatment of influenzain high-risk groups: Children, pregnant women, immunocompromised hosts, and nursing home residents. J Infect Dis 2006, 194(Suppl 2):133–138. doi: 10.1086/507548. 5. Principi N, Esposito S. (2004). Are we ready for universal influenza vaccination in paediatrics? Lancet Infect Dis 2004(4)75–83. doi: 10.1016/S1473-3099(04)00926-0. 6. Milupi M, Madeo M, Brooke N, Ahmad SJ. Neonatal influenza A/H1N1/2009 outbreak in a UK district general hospital. J Hosp Infect 2012(81)131–133. doi: 10.1016/j.jhin.2012.04.005. 7. Tsagris V, Nika A, Kyriakou D, et al. Influenza A/H1N1/2009 outbreak in a neonatal intensive care unit. J Hosp Infect 2012(81)36–40. doi: 10.1016/j.jhin.2012. 02.009. 8. Rocha G, Pissarra S, Silva G, Guimares H. Experience with oseltamivir in term and preterm newborns. Res. Gate 2010(5)327–331. doi: 10.3233/JPI-2010-0270. 9. Pannaraj PS, Tam B, Akan D. Oseltamivir treatment and prophylaxis in a neonatal intensive care unit during a 2009 H1N1 influenza outbreak. J Perinatol 2011(31)487–493. doi: 10.1038/jp.2010.159. 10. Vij NK, Stryker CC, Esper FP, et al. Influenza A/H1N1/09-10 infections in a NICU during the 2009- 2010 H1N1 pandemic. Pediatrics 2011(128)1297–1301. doi: 10.1542/peds. 2011-0219. 11. Jajoo M, Gupta R. H1N1 influenza in a preterm neonate. Indian J Pediatr 2010(77)1045–1046. doi: 10.1007/s12098-010-0166-2. 12. Bhat N, Wright JG, Broder, KR, et al. Influenza-associated deaths among children in the united states, 2003-2004. N Engl J Med 2005(353)2559–2567. doi: 10.1056/NEJMoa051721. 13. https://www.cdc.gov/flu/professionals/diagnosis/overview-testing-methods.htm. 14. Kimberlin DW, Acosta EP, Prichard MN et al. Oseltamivir pharmacokinetics, dosing, and resistance among <2 years with influenza. J Infect Dis 2013(5):709-20. doi:10.1093/infdis/jis765. Epub 2012 Dec 10. 15. Ronchi A, Michelow IC, Chapin KC, et al. Viral respiratory tract infections in the neonatal intensive care unit: the virion-i study. J. Pediatr 2014(165)690-6. doi: 10.1016/j.jpeds.2014. 05.054. 16. Coşkun O, Avci IY, Sener K, et al. Relative lymphopenia and monocytosis may be considered as a surrogate marker of pandemic influenza a (H1N1). J Clin Virol 2010(4):388-9. doi.1016/j.jcv.2010.01.007. Epub 2010 Feb 4. 17. Wang N, Liu X, Zhang Y, et al. Hematologic Markers of Influenza A H1N1 for Early Laboratory Diagnosis and Treatment Assessment. LabMedicine 2011(42)607-611. 18. Wooltorton, E. Oseltamivir (Tamiflu) unsafe in infants under 1 year old. CMAJ 2004(170):336. 19. FDA, Issuance letter for Tamiflu , 2009. Available at http://www.fda.gov/downloads/Drugs/DrugSafety/InformationbyDrugClass/UCM153547.pdf Accessed 8 September 2009. 20. Acosta EP, Jester P, Gal P, et al. Oseltamivir dosing for influenza infection in premature neonates. J. Infect Dis 2010(202)563–566. doi: 10.1086/654930. 21. Munoz FM. Influenza virus infection in infancy and early childhood. Paediatr. Respir. Rev 2003(4)99–104. doi: 10.1016/S1526-0542(03)00027-7. 22. Matheson NJ, Harnden AR, Perera R, et al. Neuraminidase inhibitors for preventing and treating influenza in children. Cochrane Database Syst Rev 2004(24):CD002744. doi: 10.1002/14651858.CD002744.pub2.
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Primary Language English
Subjects Health Care Administration
Journal Section Congress Proceedings
Authors

Şükran Yıldırım This is me

Publication Date December 10, 2019
Acceptance Date January 15, 2020
Published in Issue Year 2019 Volume: 7 Issue: Ek - IRUPEC 2019 Kongresi Tam Metin Bildirileri

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Vancouver Yıldırım Ş. Yenidoğan Yoğun Bakımda İnfluenza Salgını: İnfluenza Enfeksiyonunun Binbir Yüzü. pediatr pract res. 2019;7(Ek):539-43.