Year 2020, Volume 8 , Issue 1, Pages 7 - 11 2020-04-30

Protective Effects of Apocynin On Cecal Ligation and Puncture-Induced Lung and Renal Injuries

Ersen ERASLAN [1] , Derya GÜZEL [2] , Songül DOĞANAY [3] , Ayhan TANYELİ [4] , Mustafa Can GÜLER [5]


Aim: The possible beneficial properties of Apocynin against cecal ligation and puncture (CLP) induced lung and renal injuries were investigated in rats. Materials and Methods: 32 Wistar Albino male rats were randomized as: group I (sham), group II (CLP), group III (CLP+Apocynin 20 mg/kg), and group IV (CLP+Apocynin 50 mg/kg). CLP process was carried out under anesthesia conditions. Apocynin was administered intraperitoneally prior to the CLP model. The lung and renal tissues were excised following the experiment. Biochemical analyzes were done. Results and Conclusion: TNF-α, OSI, IL-1β, TOS, MDA levels and MPO activity elevated but SOD and TAS values declined in CLP group compared to sham group. On the other hand, SOD and TAS levels increased while MPO activity, TNF-α, IL-1β, TOS, OSI and MDA levels declined due to Apocynin treatments. As a conclusion, Apocynin is an effective agent against CLP-induced lung and renal injuries.
Apocynin, Cecal Ligation and Puncture, Lung, Renal, Rat
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Primary Language en
Subjects Health Care Sciences and Services
Journal Section Original Articles
Authors

Orcid: 0000-0003-2424-2269
Author: Ersen ERASLAN
Institution: Yozgat Bozok University
Country: Turkey


Orcid: 0000-0002-7618-5043
Author: Derya GÜZEL
Institution: SAKARYA UNIVERSITY
Country: Turkey


Orcid: 0000-0002-1730-1331
Author: Songül DOĞANAY
Institution: SAKARYA UNIVERSITY
Country: Turkey


Author: Ayhan TANYELİ (Primary Author)
Institution: ATATURK UNIVERSITY
Country: Turkey


Orcid: 0000-0001-8588-1035
Author: Mustafa Can GÜLER
Institution: ATATURK UNIVERSITY
Country: Turkey


Dates

Publication Date : April 30, 2020

Bibtex @research article { pprjournal767696, journal = {Pediatric Practice and Research}, issn = {2147-6470}, address = {}, publisher = {MediHealth Academy Yayıncılık}, year = {2020}, volume = {8}, pages = {7 - 11}, doi = {}, title = {Protective Effects of Apocynin On Cecal Ligation and Puncture-Induced Lung and Renal Injuries}, key = {cite}, author = {Eraslan, Ersen and Güzel, Derya and Doğanay, Songül and Tanyeli̇, Ayhan and Güler, Mustafa Can} }
APA Eraslan, E , Güzel, D , Doğanay, S , Tanyeli̇, A , Güler, M . (2020). Protective Effects of Apocynin On Cecal Ligation and Puncture-Induced Lung and Renal Injuries . Pediatric Practice and Research , 8 (1) , 7-11 . Retrieved from https://dergipark.org.tr/en/pub/pprjournal/issue/56707/767696
MLA Eraslan, E , Güzel, D , Doğanay, S , Tanyeli̇, A , Güler, M . "Protective Effects of Apocynin On Cecal Ligation and Puncture-Induced Lung and Renal Injuries" . Pediatric Practice and Research 8 (2020 ): 7-11 <https://dergipark.org.tr/en/pub/pprjournal/issue/56707/767696>
Chicago Eraslan, E , Güzel, D , Doğanay, S , Tanyeli̇, A , Güler, M . "Protective Effects of Apocynin On Cecal Ligation and Puncture-Induced Lung and Renal Injuries". Pediatric Practice and Research 8 (2020 ): 7-11
RIS TY - JOUR T1 - Protective Effects of Apocynin On Cecal Ligation and Puncture-Induced Lung and Renal Injuries AU - Ersen Eraslan , Derya Güzel , Songül Doğanay , Ayhan Tanyeli̇ , Mustafa Can Güler Y1 - 2020 PY - 2020 N1 - DO - T2 - Pediatric Practice and Research JF - Journal JO - JOR SP - 7 EP - 11 VL - 8 IS - 1 SN - 2147-6470- M3 - UR - Y2 - 2020 ER -
EndNote %0 Pediatric Practice and Research Protective Effects of Apocynin On Cecal Ligation and Puncture-Induced Lung and Renal Injuries %A Ersen Eraslan , Derya Güzel , Songül Doğanay , Ayhan Tanyeli̇ , Mustafa Can Güler %T Protective Effects of Apocynin On Cecal Ligation and Puncture-Induced Lung and Renal Injuries %D 2020 %J Pediatric Practice and Research %P 2147-6470- %V 8 %N 1 %R %U
ISNAD Eraslan, Ersen , Güzel, Derya , Doğanay, Songül , Tanyeli̇, Ayhan , Güler, Mustafa Can . "Protective Effects of Apocynin On Cecal Ligation and Puncture-Induced Lung and Renal Injuries". Pediatric Practice and Research 8 / 1 (April 2020): 7-11 .
AMA Eraslan E , Güzel D , Doğanay S , Tanyeli̇ A , Güler M . Protective Effects of Apocynin On Cecal Ligation and Puncture-Induced Lung and Renal Injuries. pediatr pract res. 2020; 8(1): 7-11.
Vancouver Eraslan E , Güzel D , Doğanay S , Tanyeli̇ A , Güler M . Protective Effects of Apocynin On Cecal Ligation and Puncture-Induced Lung and Renal Injuries. Pediatric Practice and Research. 2020; 8(1): 7-11.