Year 2020, Volume 8 , Issue 2, Pages 38 - 42 2020-08-31

İmmün Trombositopenili Pediatrik Hastaların Klinik Seyir ve Tedavi Yanıtı Açısından Değerlendirilmesi: Retrospektif Tek Merkez Deneyimi
Evaluation of Pediatric Patients with Immune Thrombocytopenia Regarding Clinical Course and Treatment Response: A Retrospective Single-Center Experience

Gülşah SÖĞÜT [1] , Göksel LEBLEBİSATAN [2] , Adnan BARUTÇU [3] , Yurdanur KILINÇ [4] , Hatice İ̇lgen ŞAŞMAZ [5]


Amaç: İmmün trombositopeni (ITP), çocukluk çağında edinilmiş trombositopeninin en yaygın nedenidir. Otoantikorlar ile trombositlerin yok edilmesiyle ortaya çıkan otoimmün bir hastalıktır. Bu çalışmada, hastalığın klinik özelliklerini ve buna göre tedavi yönteminin nasıl belirlendiğini araştırmayı amaçladık. Ayrıca tedavi yanıtlarının incelenmesi ve karşılaştırılması amaçlanmaktadır. Gereç ve Yöntem: Ocak 2013- Aralık 2018 tarihleri arasında Çocuk Hematoloji Polikliniği'nde İTP tanısı almış toplam 80 hasta çalışmaya alındı. Çalışma süresi boyunca tüm hastaların verilerinin eksiksiz bir şekilde kayıt altına alınmasını sağladık. İkincil trombositopeni nedenleri dışlandıktan sonra son olarak uygun tıbbi tedavi görenlerin sonuçlarını istatistiksel olarak karşılaştırdık. Bulgular: Hastaların ortalama yaşı 5 ± 2.3 yıldı; Kadınların erkeklere oranı 1’e 2 olarak bulundu. En sık görülen şikayetler arasında ilk sırada ekimoz (%63,7), ardından peteşi (%20) vardı. Dört (% 5) hasta tedavi almadı. Metilprednizolon, İVİG ve deksametazon sırasıyla 49 (% 61,2), 17 (% 21,2) ve 8 (% 10) hastaya verildi. Hem metilprednizolon hem de IVIG sadece 2 (% 2,5) hastaya verildi. Sonuç: IVIG alan ITP hastalarının, metilprednizolon alanlara göre kronikleşmeye daha fazla ilerlediği bulunmuştur. Çalışmamız ayrıca ITP'deki kronikliğin gelişimini tahmin etmek için de bilgi sunmaktadır.
Aim: Immune thrombocytopenia (ITP) is the most common cause of acquired thrombocytopenia in childhood. It is an autoimmune disease that is elicited by the destruction of platelets with autoantibodies. We aimed in this study to investigate the clinical features of the disease and provide insight into how the treatment method is determined accordingly. It is also intended to examine and compare the treatment responses. Materials and Methods: Between January 2013 and December 2018, a total of 80 patients diagnosed as ITP, at the Pediatric Hematology Outpatient Clinic were enrolled in the study. During the study period, we provided to record data of all patients thoroughly. We finally compared the results of those undergoing appropriate medical therapy statistically after the exclusion of the causes of secondary thrombocytopenia. Results: The mean age of the patients was 5 ± 2.3 years; the ratio of females to males was found to be 1 to 2. Among the most common complaints were that ecchymosis (63.7%) ranked first, followed by petechiae (%20). Four (5%) patients received no treatment. Methylprednisolone, IVIG, and dexamethasone were given in 49 (61.2%), 17 (21.2%), and 8 (10%) patients, respectively. Both of methylprednisolone and IVIG were given to only 2 (2.5%) patients. Conclusion: The ITP patients receiving IVIG have been found to progress to chronicity more than those receiving methylprednisolone. Our study also presents knowledge to be able to predict the development of chronicity in ITP.
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Primary Language en
Subjects Health Care Sciences and Services
Journal Section Original Articles
Authors

Orcid: 0000-0003-1533-2369
Author: Gülşah SÖĞÜT
Institution: Çukurova University Medical Faculty Department of Pediatrics, Adana
Country: Turkey


Orcid: 0000-0003-3435-757X
Author: Göksel LEBLEBİSATAN
Institution: Çukurova University Medical Faculty Department of Pediatric Hematology, Adana
Country: Turkey


Orcid: 0000-0001-8930-1122
Author: Adnan BARUTÇU (Primary Author)
Institution: Halfeti State Hospital, Department of Pediatrics, Şanlıurfa
Country: Turkey


Orcid: 0000-0003-3552-7008
Author: Yurdanur KILINÇ
Institution: Cukurova University Medical Faculty Department of Pediatric Hematology, Adana
Country: Turkey


Orcid: 0000-0001-9361-9838
Author: Hatice İ̇lgen ŞAŞMAZ
Institution: Çukurova University Medical Faculty Department of Pediatric Hematology, Adana
Country: Turkey


Dates

Acceptance Date : November 19, 2020
Publication Date : August 31, 2020

Bibtex @research article { pprjournal799176, journal = {Pediatric Practice and Research}, issn = {2147-6470}, address = {}, publisher = {MediHealth Academy Yayıncılık}, year = {2020}, volume = {8}, pages = {38 - 42}, doi = {}, title = {Evaluation of Pediatric Patients with Immune Thrombocytopenia Regarding Clinical Course and Treatment Response: A Retrospective Single-Center Experience}, key = {cite}, author = {Söğüt, Gülşah and Leblebi̇satan, Göksel and Barutçu, Adnan and Kılınç, Yurdanur and Şaşmaz, Hatice İ̇lgen} }
APA Söğüt, G , Leblebi̇satan, G , Barutçu, A , Kılınç, Y , Şaşmaz, H . (2020). Evaluation of Pediatric Patients with Immune Thrombocytopenia Regarding Clinical Course and Treatment Response: A Retrospective Single-Center Experience . Pediatric Practice and Research , 8 (2) , 38-42 . Retrieved from https://dergipark.org.tr/en/pub/pprjournal/issue/58042/799176
MLA Söğüt, G , Leblebi̇satan, G , Barutçu, A , Kılınç, Y , Şaşmaz, H . "Evaluation of Pediatric Patients with Immune Thrombocytopenia Regarding Clinical Course and Treatment Response: A Retrospective Single-Center Experience" . Pediatric Practice and Research 8 (2020 ): 38-42 <https://dergipark.org.tr/en/pub/pprjournal/issue/58042/799176>
Chicago Söğüt, G , Leblebi̇satan, G , Barutçu, A , Kılınç, Y , Şaşmaz, H . "Evaluation of Pediatric Patients with Immune Thrombocytopenia Regarding Clinical Course and Treatment Response: A Retrospective Single-Center Experience". Pediatric Practice and Research 8 (2020 ): 38-42
RIS TY - JOUR T1 - Evaluation of Pediatric Patients with Immune Thrombocytopenia Regarding Clinical Course and Treatment Response: A Retrospective Single-Center Experience AU - Gülşah Söğüt , Göksel Leblebi̇satan , Adnan Barutçu , Yurdanur Kılınç , Hatice İ̇lgen Şaşmaz Y1 - 2020 PY - 2020 N1 - DO - T2 - Pediatric Practice and Research JF - Journal JO - JOR SP - 38 EP - 42 VL - 8 IS - 2 SN - 2147-6470- M3 - UR - Y2 - 2020 ER -
EndNote %0 Pediatric Practice and Research Evaluation of Pediatric Patients with Immune Thrombocytopenia Regarding Clinical Course and Treatment Response: A Retrospective Single-Center Experience %A Gülşah Söğüt , Göksel Leblebi̇satan , Adnan Barutçu , Yurdanur Kılınç , Hatice İ̇lgen Şaşmaz %T Evaluation of Pediatric Patients with Immune Thrombocytopenia Regarding Clinical Course and Treatment Response: A Retrospective Single-Center Experience %D 2020 %J Pediatric Practice and Research %P 2147-6470- %V 8 %N 2 %R %U
ISNAD Söğüt, Gülşah , Leblebi̇satan, Göksel , Barutçu, Adnan , Kılınç, Yurdanur , Şaşmaz, Hatice İ̇lgen . "Evaluation of Pediatric Patients with Immune Thrombocytopenia Regarding Clinical Course and Treatment Response: A Retrospective Single-Center Experience". Pediatric Practice and Research 8 / 2 (August 2020): 38-42 .
AMA Söğüt G , Leblebi̇satan G , Barutçu A , Kılınç Y , Şaşmaz H . Evaluation of Pediatric Patients with Immune Thrombocytopenia Regarding Clinical Course and Treatment Response: A Retrospective Single-Center Experience. pediatr pract res. 2020; 8(2): 38-42.
Vancouver Söğüt G , Leblebi̇satan G , Barutçu A , Kılınç Y , Şaşmaz H . Evaluation of Pediatric Patients with Immune Thrombocytopenia Regarding Clinical Course and Treatment Response: A Retrospective Single-Center Experience. Pediatric Practice and Research. 2020; 8(2): 38-42.
IEEE G. Söğüt , G. Leblebi̇satan , A. Barutçu , Y. Kılınç and H. Şaşmaz , "Evaluation of Pediatric Patients with Immune Thrombocytopenia Regarding Clinical Course and Treatment Response: A Retrospective Single-Center Experience", Pediatric Practice and Research, vol. 8, no. 2, pp. 38-42, Aug. 2020