1. DergiPark
  2. Pediatric Practice and Research
  3. Archive
  4. Volume 8, Issue 2
Year 2020, Volume 8 , Issue 2, Pages 43 - 45 2020-08-31

An Atypical Hemolytic Uremic Syndrome Case with STEC Positivity and Myocardial Involvement
Myokardit ve STEC Pozitifliği ile Seyreden Atipik HÜS Tanılı Olgu

Eylül ŞAHİN [1] , Fatma DEVRİM [2] , Büşra KOÇ [3] , Aslı KANTAR [4] , Gülhan ATAKUL [5] , Pınar SEVEN [6] , Hasan AĞIN [7] , Nida DİNÇEL [8]

Abstract

Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy characterized by intravascular hemolysis, thrombocytopenia and acute renal failure. HUS is generally classified into two types. While typical HUS follows a gastrointestinal infection with shiga-toxin producing E. coli (STEC), aHUS is associated with autoantibodies or mutations that lead to irregular complement activation. However, according to some recent studies, it was observed that diarrhea and multisystem involvement were seen in both HUS types. STEC positivity was also detected in a little percent of aHUS cases. Histopathological findings compatible with myocarditis were found in postmortem examinations in some cases. Although our case was diagnosed with atypical HUS, typical HUS symptoms such as bloody diarrhea and Shiga toxin 2 positivity were reported and myocardial involvement was observed as a rare complication.
Hemolitik üremik sendrom (HÜS), intravasküler hemoliz, trombositopeni ve akut böbrek yetmezliği ile karakterize trombotik bir mikroanjiyopatidir. Hastalık genellikle shiga-toksin üreten E. coli (STEC) enfeksiyonu ile birliktelik gösteren tipik HÜS ve kontrolsüz kompleman aktivasyonu ile ortaya çıkan atipik HÜS (aHÜS) olarak sınıflandırılmaktadır. Ancak son zamanlarda yapılan bazı çalışmalara göre diyarenin her iki HUS tipinde de görüldüğü , aHÜS olgularında da STEC pozitifliği ile karşılaşıldığı ve her iki HÜS tipinde de multisistemik tutulumun olduğu görülmüştür. Bazı postmortem incelemelerde miyokardit ile uyumlu histopatolojik bulgular saptanmıştır. Bu raporda kanlı ishal ile başvuran, Shiga toksin 2 pozitifliği göstermesine rağmen atipik HÜS olarak değerlendirilen ve nadiren görülen miyokard tutulumu gözlenen bir olgu sunulmuştur.

References

  • 1. Yürük Yıldırım ZN, Yılmaz A. (2014) Atipik Hemolitik Üremik Sendrom, Çocuk Dergisi 14(3):108-115
  • 2.Davin JC, Majoie C, Groothoff J, Gracchi V, Bouts A, Goodship TH, Loirat C. (2011) Prevention of large-vessel stenoses in atypical hemolytic uremic syndrome associated with complement dysregulation. Pediatr Nephrol. 26:155–157.
  • 3. Neuhaus TJ, Calonder S, Leumann EP. Heterogeneity of atypical hemolytic uremic syndromes. (1997) Arch Dis Child; 76(6): 518-21.
  • 4. Hosler GA, Cusumano AM, Hutchins GM. (2003) Thrombotic Thrombocytopenic Purpura and Hemolytic Uremic Syndrome Are Distinct Pathologic Entities. A Review of 56 Autopsy Cases, Arch Pathol Lab Med; Jul;127(7):834-9.
  • 5. Eckart P, Guillot M, Jokic M, Maragnes P, Boudailliez B, Palcoux JB, Desvignes V. (1999) Cardiac Involvement During Classic Hemolytic Uremic Syndrome, Arch Pediatr, Apr;6(4):430-3.
  • 6. Calvaruso L, Naticchia A, Ferraro PM,Vischini G, Costanzi S. (2019) Deterioration in Clinical Status Is Not Enough to Suspend Eculizumab: A Genetic Complement-Mediated Atypical Hemolytic Uremic Syndrome Case Report. Case Rep Nephrol. doi:10.1155/2019/9264824.
  • 7. Costin M, Cinteza E, Balgradean M. (2019) Hemolytic Uremic Syndrome – Case report. Maedica (Buchar). Sep;14(3):298-300.
  • 8. Mohammed SK, Mubarik A, Nadeem B, Khan K, Muddassir S. (2019) Atypical Hemolytic Uremic Syndrome:A Case Report.Cureus. May 10;11(5):e4634.
  • 9. Basnayake BMDB, Wazil AWM, Nanayakkara N, Samarakoon SMDK, Senavirathne EMSK, Thangarajah BUEWDR, Karunasena N, Mahanama RMBSS. (2020) Atypical hemolytic uremic syndrome: a case report. J Med Case Rep. Jan 13;14(1):11.
  • 10. Campbell CM, Cassol C, Cataland SR, Kahwash R. (2020) Atypical hemolytic uremic syndrome: a case report of a rare cause of reversible cardiomyopathy. Eur Heart J Case Rep. Mar 12;4(2):1-6.

Details

Primary Language en
Subjects Health Care Sciences and Services
Journal Section Case Reports
Authors

Author: Eylül ŞAHİN
Institution: SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İZMİR DR. BEHÇET UZ ÇOCUK HASTALIKLARI VE CERRAHİSİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ
Country: Turkey

Author: Fatma DEVRİM
Institution: SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İZMİR DR. BEHÇET UZ ÇOCUK HASTALIKLARI VE CERRAHİSİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ
Country: Turkey

Author: Büşra KOÇ (Primary Author)
Institution: SBÜ Dr Behçet Uz Çocuk Hastalıkları ve Cerrahisi Eğitim ve Araştırma Hastanesi
Country: Turkey

Author: Aslı KANTAR
Institution: SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İZMİR DR. BEHÇET UZ ÇOCUK HASTALIKLARI VE CERRAHİSİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ
Country: Turkey

Author: Gülhan ATAKUL
Institution: SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İZMİR DR. BEHÇET UZ ÇOCUK HASTALIKLARI VE CERRAHİSİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ
Country: Turkey

Author: Pınar SEVEN
Institution: SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İZMİR DR. BEHÇET UZ ÇOCUK HASTALIKLARI VE CERRAHİSİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ
Country: Turkey

Author: Hasan AĞIN
Institution: SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İZMİR DR. BEHÇET UZ ÇOCUK HASTALIKLARI VE CERRAHİSİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ
Country: Turkey

Author: Nida DİNÇEL
Institution: Dr. Behçet Uz Children's Diseases and Surgery Health Practice and Research Center, University of Health Sciences, İzmir, Turkey
Country: Turkey
Dates

Acceptance Date : November 26, 2020
Publication Date : August 31, 2020

Cite

Bibtex @case report { pprjournal824099, journal = {Pediatric Practice and Research}, issn = {2147-6470}, address = {}, publisher = {MediHealth Academy Yayıncılık}, year = {2020}, volume = {8}, pages = {43 - 45}, doi = {}, title = {An Atypical Hemolytic Uremic Syndrome Case with STEC Positivity and Myocardial Involvement}, key = {cite}, author = {Şahi̇n, Eylül and Devri̇m, Fatma and Koç, Büşra and Kantar, Aslı and Atakul, Gülhan and Seven, Pınar and Ağın, Hasan and Di̇nçel, Nida} }
APA Şahi̇n, E , Devri̇m, F , Koç, B , Kantar, A , Atakul, G , Seven, P , Ağın, H , Di̇nçel, N . (2020). An Atypical Hemolytic Uremic Syndrome Case with STEC Positivity and Myocardial Involvement . Pediatric Practice and Research , 8 (2) , 43-45 . Retrieved from https://dergipark.org.tr/en/pub/pprjournal/issue/58042/824099
MLA Şahi̇n, E , Devri̇m, F , Koç, B , Kantar, A , Atakul, G , Seven, P , Ağın, H , Di̇nçel, N . "An Atypical Hemolytic Uremic Syndrome Case with STEC Positivity and Myocardial Involvement" . Pediatric Practice and Research 8 (2020 ): 43-45 <https://dergipark.org.tr/en/pub/pprjournal/issue/58042/824099>
Chicago Şahi̇n, E , Devri̇m, F , Koç, B , Kantar, A , Atakul, G , Seven, P , Ağın, H , Di̇nçel, N . "An Atypical Hemolytic Uremic Syndrome Case with STEC Positivity and Myocardial Involvement". Pediatric Practice and Research 8 (2020 ): 43-45
RIS TY - JOUR T1 - An Atypical Hemolytic Uremic Syndrome Case with STEC Positivity and Myocardial Involvement AU - Eylül Şahi̇n , Fatma Devri̇m , Büşra Koç , Aslı Kantar , Gülhan Atakul , Pınar Seven , Hasan Ağın , Nida Di̇nçel Y1 - 2020 PY - 2020 N1 - DO - T2 - Pediatric Practice and Research JF - Journal JO - JOR SP - 43 EP - 45 VL - 8 IS - 2 SN - 2147-6470- M3 - UR - Y2 - 2020 ER -
EndNote %0 Pediatric Practice and Research An Atypical Hemolytic Uremic Syndrome Case with STEC Positivity and Myocardial Involvement %A Eylül Şahi̇n , Fatma Devri̇m , Büşra Koç , Aslı Kantar , Gülhan Atakul , Pınar Seven , Hasan Ağın , Nida Di̇nçel %T An Atypical Hemolytic Uremic Syndrome Case with STEC Positivity and Myocardial Involvement %D 2020 %J Pediatric Practice and Research %P 2147-6470- %V 8 %N 2 %R %U
ISNAD Şahi̇n, Eylül , Devri̇m, Fatma , Koç, Büşra , Kantar, Aslı , Atakul, Gülhan , Seven, Pınar , Ağın, Hasan , Di̇nçel, Nida . "An Atypical Hemolytic Uremic Syndrome Case with STEC Positivity and Myocardial Involvement". Pediatric Practice and Research 8 / 2 (August 2020): 43-45 .
AMA Şahi̇n E , Devri̇m F , Koç B , Kantar A , Atakul G , Seven P , Ağın H , Di̇nçel N . An Atypical Hemolytic Uremic Syndrome Case with STEC Positivity and Myocardial Involvement. pediatr pract res. 2020; 8(2): 43-45.
Vancouver Şahi̇n E , Devri̇m F , Koç B , Kantar A , Atakul G , Seven P , Ağın H , Di̇nçel N . An Atypical Hemolytic Uremic Syndrome Case with STEC Positivity and Myocardial Involvement. Pediatric Practice and Research. 2020; 8(2): 43-45.
IEEE E. Şahi̇n , F. Devri̇m , B. Koç , A. Kantar , G. Atakul , P. Seven , H. Ağın and N. Di̇nçel , "An Atypical Hemolytic Uremic Syndrome Case with STEC Positivity and Myocardial Involvement", Pediatric Practice and Research, vol. 8, no. 2, pp. 43-45, Aug. 2020
Authors of the Article
Eylül ŞAHİN [1]
Fatma DEVRİM [2]
Büşra KOÇ [3]
Aslı KANTAR [4]
Gülhan ATAKUL [5]
Pınar SEVEN [6]
Hasan AĞIN [7]
Nida DİNÇEL [8]
Submit Article
Accepted Submissions
Archive
Editorial Board
Contact