Year 2021, Volume 9 , Issue 1, Pages 45 - 49 2021-04-30

Çocuklarda COVID-19 ve Karaciğer
Çocuklarda COVID-19 ve Karaciğer

Anna Carina ERGANİ [1] , Reyhan GÜMÜŞTEKİN [2] , Meltem GÜMÜŞ [3] , Halil Haldun EMİROĞLU [4]


The coronavirus disease 2019 (COVID-19) epidemic caused by SARS-CoV-2 continues to be a major health and economic problem worldwide. There is not enough information about how the infection affects the liver in children and chronic liver disease is a risk factor for this infection. Different treatments are being studied for COVID-19, some of which have been linked to hepatotoxicity. Due to the increasing number of patients worldwide, new approaches have been developed to protect those with chronic liver disease from SARS-CoV-2 infection, considering that the risk of severe disease may increase. For this purpose, COVID-19 has also published a special guide for those with chronic liver disease.
SARS-CoV-2’nin neden olduğu koronavirüs hastalığı 2019 (COVID-19) salgını, dünya çapında önemli bir sağlık ve ekonomik sorun olmaya devam etmektedir. Çocuklarda enfeksiyonun karaciğeri nasıl etkilediğine ve kronik karaciğer hastalığının enfeksiyona yakalanma risk faktörü olmasına ilişkin bilgiler henüz yeterli düzeyde değildir. COVID-19 için farklı tedaviler incelenmektedir ve bunlardan bazıları hepatotoksisite ile ilişkilendirilmiştir. Dünya çapında artan hasta sayısı nedeniyle, ağır hastalık riski olasılığının artabileceği düşünülerek kronik karaciğer hastalığı olanları SARS-CoV-2 enfeksiyonundan korumak için yeni yaklaşımlar geliştirilmeye başlanmıştır. Bu amaçla kronik karaciğer hastalığı olanlar için COVID-19 özel bir rehberi de yayınlamıştır.
  • 1. Cevik M, Bamford C, Ho A. COVID-19 Pandemic-a focused review for clinicians. Clinical Microbiology and Infection. 2020 Apr 21.
  • 2. Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. New Engl J Med. 2020;382:727–33.
  • 3. Siddiqi HK, Mehra MR. COVID-19 illness in native and immunosuppressed states: a clinical-therapeutic staging proposal. The Journal of Heart and Lung Transplantation. 2020
  • 4. Portincasa P., Krawczyk M., Antonia Machill, Lammert F., Di Ciaula A. Hepatic consequences of COVID-19 infection. Lapping or biting?. Eur J Intern Med. 2020 Jul; 77: 18–24.
  • 5. Zhang C., Shi L., Wang F.S. Liver injury in COVID-19: management and challenges. Lancet Gastroenterol Hepatol. 2020;5:428–430.
  • 6. Cai Q., Huang D., Yu H., Zhu Z., Xia Z., Su Y. Characteristics of liver tests in COVID-19 patients. J Hepatol. 2020 doi: 10.1016/j.jhep.2020.04.006.
  • 7. Bangash M.N., Patel J., Parekh D. COVID-19 and the liver: little cause for concern. Lancet Gastroenterol Hepatol. 2020 doi: 10.1016/S2468-1253(20)30084-4.
  • 8. Ridruejo E., Soza A. The liver in times of COVID-19: What hepatologists should know. Ann Hepatol. 2020 July-August; 19(4): 353–358.
  • 9. Cai Q, Huang D, Yu H, Zhu Z, Xia Z, Su Y. Characteristics of Liver Tests in COVID-19 Patients. J Hepatol. 2020
  • 10.Schaefer E.A.K., Arvind A., Chung R.T. et al. Interrelationship Between Coronavirus Infection and Liver Disease. CLINICAL LIVER DISEASE, VOL 15, NO 5, MAY 2020.
  • 11. Lei F, Liu YM, Zhou F, Qin JJ, Zhang P, Zhu L. Longitudinal association between markers of liver injury and mortality in COVID-19 in China. Hepatology. 2020
  • 12. Fan Z, Chen L, Li J, Cheng X, Jingmao Y, Tian C. Clinical Features of COVID-19-Related Liver Damage. Clin Gastroenterol Hepatol. 2020
  • 13. Isabel Garrido I., Liberal R., Macedo G. COVID‐19 and liver disease—what we know on 1st May 2020. Aliment Pharmacol Ther. 2020 Jun 2 : 10.1111/apt.15813.
  • 14. Sultan S, Altayar O, Siddique SM, et al. AGA institute rapid review of the GI and liver manifestations of COVID-19, meta-analysis of international data, and recommendations for the consultative medicine of patients with COVID-19. Gastroenterology. 2020 May; doi: 10.1053/j.gastro.2020.05.001.
  • 15. Ludvigsson F. Systematic review of COVID‐19 in children shows milder cases and a better prognosis than adults. Acta Paediatr. 2020;109:1088‐1095.
  • 16. Qiu H, Wu J, Hong L, et al. Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID‐19) in Zhejiang, China: an observational cohort study. Lancet Infect Dis. 2020.
  • 17. Zhu H, Wang L, Fang C, et al. Clinical analysis of 10 neonates born to mothers with 2019‐nCoV pneumonia. Transl Pediatr. 2020;9:51‐60.
  • 18. American Association for the Study of Liver Diseases . Clinical insights for hepatology and liver transplant providers during the COVID‐19 pandemic. https://www.aasld.org/about-aasld/covid-19-resources. Accessed April 14, 2020
  • 19. Chai X, Hu L, Zhang Y, et al. Specific ACE2 expression in cholangiocytes may cause liver damage after 2019‐nCoV infection. bioRxiv. 2020. 10.1101/2020.02.03.931766
  • 20. Xu Z, Shi L, Wang Y, et al. Pathological findings of COVID‐19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020;8:420‐422.
  • 21. Zhang Y, Zheng L, Liu L, Zhao M, Xiao J, Zhao Q. Liver impairment in COVID‐19 patients: a retrospective analysis of 115 cases from a single center in Wuhan city, China. Liver Int. 2020. 10.1111/liv.14455.
  • 22. Tan Y‐J, Fielding BC, Goh P‐Y, et al. Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase‐dependent pathway. J Virol. 2004;78:14043‐14047.
  • 23. Bangash N, Patel J, Parekh D. COVID‐19 and the liver: little cause for concern. Lancet Gastroenterol Hepatol. 2020;5:529–530.
  • 24. Adams H, Hubscher G. Systemic viral infections and collateral damage in the liver. Am J Pathol. 2006;168:1057‐1059.
  • 25. Kabaçam G., Dayangaç M., Üçbilek E., et al. The COVID-19 pandemic: Clinical practice advice for gastroenterologists, hepatologists, and liver transplant specialists. Turk J Gastroenterol. 2020 May; 31(5): 348–355.
  • 26. Rohani P., Badi A.S., Moshiri A., Siadat D.S. Coronavirus disease 2019 (COVID-19) and pediatric gastroenterology. Gastroenterol Hepatol Bed Bench. 2020 Autumn; 13(4): 351–354.
  • 27. Boettler T, Newsome PN, Mondelli MU, et al. Care of patients with liver disease during the COVID‐19 pandemic: EASL‐ESCMID position paper. JHEP Rep. 2020;2(3):100113.
  • 28. Strnad P, Tacke F, Koch A, Trautwein C. Liver ‐guardian, modifier and target of sepsis. Nat Rev Gastroenterol Hepatol. 2017;14:55‐66.
  • 29. Lei S., Jiang F., Su W., Chen C., Chen J., Mei W. Clinical characteristics and outcomes of patients undergoing surgeries during the incubation period of COVID-19 infection. EClinicalMedicine. 2020;100331 doi: 10.1016/j.eclinm.2020.100331.
  • 30. Boettler T., Newsome P.N., Mondelli M.U., Maticic M., Cordero E., Cornberg M. Care of patients with liver disease during the COVID-19 pandemic: EASL-ESCMID position paper. JHEP Rep. 2020;2:100113. doi: 10.1016/j.jhepr.2020.100113.
  • 31. Fix O.K., Hameed B., Fontana R.J., Kwok R.M., McGuire B.M., Mulligan D.C. Clinical best practice advice for hepatology and liver transplant providers during the COVID-19 pandemic: AASLD expert panel consensus statement. Hepatology. 2020 doi: 10.1002/hep.31281.
  • 32. Sulkowski MS. Drug‐induced liver injury associated with antiretroviral therapy that includes HIV‐1 protease inhibitors. Clin Infect Dis. 2004;38:S90‐S97.
  • 33. Fries JF, Singh G, Lenert L, Furst DE. Aspirin, hydroxychloroquine, and hepatic enzyme abnormalities with methotrexate in rheumatoid arthritis. Arthritis Rheum. 1990;33:1611‐1619.
  • 34. Meyerowitz EA, Vannier AGL, Friesen MGN, et al. Rethinking the role of hydroxychloroquine in the treatment of COVID‐19. FASEB J. 2020;34:6027‐6037.
  • 35. Genovese MC, Kremer JM, van Vollenhoven RF, et al. Transaminase levels and hepatic events during tocilizumab treatment: pooled analysis of long‐term clinical trial safety data in rheumatoid arthritis. Arthritis Rheumatol. 2017;69:1751‐1761.
  • 36. Sanders JM, Monogue ML, Jodlowski TZ, Cutrell JB. Pharmacologic treatments for Coronavirus disease 2019 (COVID-19). A review. JAMA. Apr 13
  • 37. Grein J, Ohmagari N, Shin D, et al. Compassionate use of remdesivir for patients with severe Covid-19. N Engl J Med. 2020 Apr 10; doi: 10.1056/NEJMoa2007016.
  • 38. Chen C, Huang J, Yin P, et al. Favipiravir versus arbidol for COVID‐ 19: a randomized clinical trial. medRxiv. 2020. 10.1101/2020.03.17.20037432
Primary Language tr
Subjects Health Care Sciences and Services
Journal Section Reviews
Authors

Author: Anna Carina ERGANİ (Primary Author)
Institution: Selçuk üniversitesi tıp fakültesi Çocuk Gastroenterolojisi
Country: Turkey


Orcid: 0000-0001-5813-4448
Author: Reyhan GÜMÜŞTEKİN
Institution: SELÇUK ÜNİVERSİTESİ
Country: Turkey


Author: Meltem GÜMÜŞ
Institution: SELÇUK ÜNİVERSİTESİ
Country: Turkey


Author: Halil Haldun EMİROĞLU
Institution: SELÇUK ÜNİVERSİTESİ
Country: Turkey


Dates

Acceptance Date : March 25, 2021
Publication Date : April 30, 2021

Bibtex @review { pprjournal850029, journal = {Pediatric Practice and Research}, issn = {2147-6470}, address = {}, publisher = {MediHealth Academy Yayıncılık}, year = {2021}, volume = {9}, pages = {45 - 49}, doi = {10.21765/pprjournal.850029}, title = {Çocuklarda COVID-19 ve Karaciğer}, key = {cite}, author = {Ergani, Anna Carina and Gümüştekin, Reyhan and Gümüş, Meltem and Emiroğlu, Halil Haldun} }
APA Ergani, A , Gümüştekin, R , Gümüş, M , Emiroğlu, H . (2021). Çocuklarda COVID-19 ve Karaciğer . Pediatric Practice and Research , 9 (1) , 45-49 . DOI: 10.21765/pprjournal.850029
MLA Ergani, A , Gümüştekin, R , Gümüş, M , Emiroğlu, H . "Çocuklarda COVID-19 ve Karaciğer" . Pediatric Practice and Research 9 (2021 ): 45-49 <https://dergipark.org.tr/en/pub/pprjournal/issue/61769/850029>
Chicago Ergani, A , Gümüştekin, R , Gümüş, M , Emiroğlu, H . "Çocuklarda COVID-19 ve Karaciğer". Pediatric Practice and Research 9 (2021 ): 45-49
RIS TY - JOUR T1 - Çocuklarda COVID-19 ve Karaciğer AU - Anna Carina Ergani , Reyhan Gümüştekin , Meltem Gümüş , Halil Haldun Emiroğlu Y1 - 2021 PY - 2021 N1 - doi: 10.21765/pprjournal.850029 DO - 10.21765/pprjournal.850029 T2 - Pediatric Practice and Research JF - Journal JO - JOR SP - 45 EP - 49 VL - 9 IS - 1 SN - 2147-6470- M3 - doi: 10.21765/pprjournal.850029 UR - https://doi.org/10.21765/pprjournal.850029 Y2 - 2021 ER -
EndNote %0 Pediatric Practice and Research Çocuklarda COVID-19 ve Karaciğer %A Anna Carina Ergani , Reyhan Gümüştekin , Meltem Gümüş , Halil Haldun Emiroğlu %T Çocuklarda COVID-19 ve Karaciğer %D 2021 %J Pediatric Practice and Research %P 2147-6470- %V 9 %N 1 %R doi: 10.21765/pprjournal.850029 %U 10.21765/pprjournal.850029
ISNAD Ergani, Anna Carina , Gümüştekin, Reyhan , Gümüş, Meltem , Emiroğlu, Halil Haldun . "Çocuklarda COVID-19 ve Karaciğer". Pediatric Practice and Research 9 / 1 (April 2021): 45-49 . https://doi.org/10.21765/pprjournal.850029
AMA Ergani A , Gümüştekin R , Gümüş M , Emiroğlu H . Çocuklarda COVID-19 ve Karaciğer. pediatr pract res. 2021; 9(1): 45-49.
Vancouver Ergani A , Gümüştekin R , Gümüş M , Emiroğlu H . Çocuklarda COVID-19 ve Karaciğer. Pediatric Practice and Research. 2021; 9(1): 45-49.
IEEE A. Ergani , R. Gümüştekin , M. Gümüş and H. Emiroğlu , "Çocuklarda COVID-19 ve Karaciğer", Pediatric Practice and Research, vol. 9, no. 1, pp. 45-49, Apr. 2021, doi:10.21765/pprjournal.850029