Abstract
Cutaneous involvement is seen in very few patients with candidemia. Cutaneous involvement of candidemia is usually seen in immunocompromised patients with hematologic-oncologic diseases. Lesions may be maculopapular or nodular.
In this case report, cutaneous lesions due to disseminated candidemia in an eight-year-old child with leukemia and febrile neutropenia are presented. The general condition of the patient was quite poor. Blood and port cultures grew resistant Candida. The diagnosis was made clinically. The patient was given amphotericin B and voriconazole combination therapy. The lesions disappeared.
Today, Candida spp. infections are becoming more common, and the rate of skin involvement is also increasing. However, the diagnosis of Candida skin involvement may be difficult. Histopathology can be used in the diagnosis. Skin involvement is more common in candidemia patients with risk factors, especially in patients with Candida tropicalis growth.
Keywords
References
- 1. Togay A, Bayraktar B, Yıldız Sevgi D, Bulut E. Determination of candida species and their antifungal susceptibilities isolated from inpatients. Med Bull Sisli Etfal Hosp. 2015;49(4):266-8.
- 2. Er H, Özkalay Yılmaz N, Karaca Derici Y, Hancı S, Saba Çopur Ş. Kandidemi etkenlerinin tür dağılımı ve duyarlılıkları: Hastanemizde ampirik antifungal tedavi politikası değiştirilmeli mi? [Distribution and Susceptibilities of Pathogens causing Candidemia: Should Empirical Antifungal Treatment Policy Be Changed in Our Hospital?]. Turk Mikrobiyol Cemiy Derg. 2021;51(2):150-5.
- 3. Epelbaum O, Chasan R. Candidemia in the Intensive Care Unit. Clin Chest Med. 2017;38(3):493-17.
- 4. Alan MS. İnvazif Fungal İnfeksiyonlarda Klinik Özellikler: Aspergilloz, Kandidiyaz ve Mukormikoz [Clinical Features of Invasive Fungal Infections: Aspergillosis, Candidiasis and Mucormycosis]. Klimik Derg. 2019;32(Suppl. 2):124-7.
- 5. Pedraz J, Delgado-Jiménez Y, Pérez-Gala S, Nam-Cha S, Fernández-Herrera J, García-Diez A. Cutaneous expression of systemic candidiasis. Clin Exp Dermatol. 2009;34(1):106-10.
- 6. Guarana M, Nucci M. Acute disseminated candidiasis with skin lesions: a systematic review. Clin Microbiol Infect. 2018;24(3):246-5.
- 7. Gamaletsou MN, Walsh TJ, Zaoutis T, Pagoni M, et al. A prospective, cohort, multicentre study of candidaemia in hospitalized adult patients with haematological malignancies. Clin Microbiol Infect. 2014 Jan;20(1):O50-7.
- 8. Deveci B, Saba R. Antifungal prophylaxis in haematological patients. Klimik Derg. 2019; 32(Suppl. 2): 163-7. [in Turkish]
Abstract
Kandidemili hastaların çok az bir kısmında kutanöz tutulum görülür. Kandideminin kutanöz tutulumu genellikle immün sistemi zayıf olan, hematolojik-onkolojik hastalığı olanlarda görülür. Lezyonlar makülopapüler ya da nodüler olabilir.
Bu olgu sunumunda lösemi tanılı, febril nötropenisi olan 8 yaşında çocuk hastada dissemine kandidemiye bağlı kutanöz lezyonlar sunulmaktadır. Hastanın genel durumu oldukça kötüydü. Kan ve port kültüründe dirençli Candida üremesi vardı. Tanı klinik olarak koyuldu. Hastaya amfoterisin B ve vorikanazol kombinasyon tedavisi verildi. Lezyonları kayboldu.
Günümüzde Candida spp. enfeksiyonlarının sık görülmesiyle beraber cilt tutulumu oranı da artmaktadır. Fakat Candida deri tutulumu tanısı güç olabilir. Histopatoloji tanıda kullanılabilir. Risk faktörlerine sahip kandidemili olgularda özellikle Candida tropicalis üremesi olan olgularda deri tutulumu daha sık görülmektedir.
Keywords
References
- 1. Togay A, Bayraktar B, Yıldız Sevgi D, Bulut E. Determination of candida species and their antifungal susceptibilities isolated from inpatients. Med Bull Sisli Etfal Hosp. 2015;49(4):266-8.
- 2. Er H, Özkalay Yılmaz N, Karaca Derici Y, Hancı S, Saba Çopur Ş. Kandidemi etkenlerinin tür dağılımı ve duyarlılıkları: Hastanemizde ampirik antifungal tedavi politikası değiştirilmeli mi? [Distribution and Susceptibilities of Pathogens causing Candidemia: Should Empirical Antifungal Treatment Policy Be Changed in Our Hospital?]. Turk Mikrobiyol Cemiy Derg. 2021;51(2):150-5.
- 3. Epelbaum O, Chasan R. Candidemia in the Intensive Care Unit. Clin Chest Med. 2017;38(3):493-17.
- 4. Alan MS. İnvazif Fungal İnfeksiyonlarda Klinik Özellikler: Aspergilloz, Kandidiyaz ve Mukormikoz [Clinical Features of Invasive Fungal Infections: Aspergillosis, Candidiasis and Mucormycosis]. Klimik Derg. 2019;32(Suppl. 2):124-7.
- 5. Pedraz J, Delgado-Jiménez Y, Pérez-Gala S, Nam-Cha S, Fernández-Herrera J, García-Diez A. Cutaneous expression of systemic candidiasis. Clin Exp Dermatol. 2009;34(1):106-10.
- 6. Guarana M, Nucci M. Acute disseminated candidiasis with skin lesions: a systematic review. Clin Microbiol Infect. 2018;24(3):246-5.
- 7. Gamaletsou MN, Walsh TJ, Zaoutis T, Pagoni M, et al. A prospective, cohort, multicentre study of candidaemia in hospitalized adult patients with haematological malignancies. Clin Microbiol Infect. 2014 Jan;20(1):O50-7.
- 8. Deveci B, Saba R. Antifungal prophylaxis in haematological patients. Klimik Derg. 2019; 32(Suppl. 2): 163-7. [in Turkish]
Details
| Primary Language | English |
|---|---|
| Subjects | Pediatric Infectious Diseases, Paediatrics (Other) |
| Journal Section | Case Reports |
| Authors | |
| Early Pub Date | July 28, 2024 |
| Publication Date | July 31, 2024 |
| Submission Date | June 11, 2024 |
| Acceptance Date | July 27, 2024 |
| Published in Issue | Year 2024 Volume: 12 Issue: 2 |
