Red Blood Cell Transfusions in the Pediatric Intensive Care Unit of the University Hospital: Are they in accordance with the Current Guidelines?
Year 2024,
Volume: 12 Issue: 3, 77 - 82, 29.10.2024
Resul Yılmaz
,
Şeyma Işık Bedir
Abstract
Objectives. – Blood component transfusion is a common procedure used during hospital admissions; however, it is not risk-free. The evaluation of correct use of blood products (BP) is of vast importance considering the risks and costs implied in their use. Our principal objective was to evaluate the adherence to international guidelines for erythrocyte suspension (ES) transfusion in pediatric patients at a third level university hospital.
Material and methods. – A retrospective descriptive analytical study was conducted to report the incidence of incorrect use of ES transfusion in pediatric patients (1 month to 18 years of age). In a timeline period of 1 years, 155 medical records were analyzed and a total of 53 ES transfusions selected as study sample. The variables studied were volume, infusion time, and transfusion criteria. Indications were evaluated in patient’s medical records according to international guidelines.
Results. – Of the transfusions analyzed, 54% were classified as incorrect mainly due to lack of transfusion criteria fulfillment. ES transfusion indications in pediatric patients adhered poorly to international guidelines.
Conclusion. – The implementation of effective programs for education and information on the use of ES transfusions are needed to increase compliance with current guidelines.
Ethical Statement
Selçuk Üniversitesi Tıp Fakültesi Yerel Etik kurulu’nun 14/02/2023 tarih ve 2023/98 sayılı onam kararı
References
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- 2. Fortin S, Cardona LG, Latreille M, Tucci M, Lacroix J. Blood transfusion in acute and chronic pediatric settings: beliefs and practices. Transfusion. 2016;56(1):130-8.
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- 7. New HV, Berryman J, Bolton-Maggs PH, Cantwell C, Chalmers EA, Davies T, et al. Guidelines on transfusion for fetuses, neonates and older children. Br J Haematol. 2016;175(5):784-828.
- 8. Carson JL, Grossman BJ, Kleinman S, Tinmouth AT, Marques MB, Fung MK, et al. Red blood cell transfusion: a clinical practice guideline from the AABB*. Ann Intern Med. 2012;157(1):49-58.
- 9. Surial B, Burkhart A, Terliesner N, Morgenthaler M, Bächli E. Adherence to transfusion guidelines: are we prepared for the Smarter Medicine or Choosing Wisely initiative? Swiss Med Wkly. 2015;145:w14084.
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- 11. TÜRK EONATOLOJİ DERNEĞİ. KAN ÜRÜNLERİ TRANSFÜZYON REHBERİ 2021 GÜNCELLEMESİ. 2021.
- 12. Ozgonenel B, Nash TA, Rajpurkar M. Blood Components for Pediatric Transfusions. Pediatr Rev. 2020;41(5):259-61.
- 13. Villarreal-Martínez L, Cázares-Perales E, Domínguez-Varela I, Godoy-Salinas E, Villarreal-Martinez D, Gutiérrez-Fernández D, et al. Blood transfusion in children at a university hospital in a middle-income country: The need to reinforce adherence to current guidelines. Transfus Clin Biol. 2020;27(2):65-9.
- 14. Saldaña-Casas OF, De la Torre-Fernández A, Guzmán-García M, Blas-Mendiola C, Gómez-Gómez M, Saltigeral-Simental P. Blood component transfusions in a privated hospital for children. Rev Mex Pediatr. 2005;72(2):65-9.
- 15. Sharif M, Saxena A, Singh S, Manchala S, Jafri N. Blood Component Transfusion in a Tertiary Care Hospital. Indian J Pediatr. 2020;87(5):339-44.
- 16. Mokhtar G, Adly A, Baky AA, Ezzat D, Hakeem GA, Hassab H, et al. Transfusion of blood components in pediatric age groups: an evidence-based clinical practice guideline adapted for the use in Egypt using 'Adapted ADAPTE'. Ann Hematol. 2024;103(4):1373-88.
- 17. Dasararaju R, Marques MB. Adverse effects of transfusion. Cancer Control. 2015;22(1):16-25.
- 18. Nguyen NT, Titze TL, Nissen-Meyer LSH. Evaluation of transfusion reactions in patients following transfusion of blood components containing antibodies to HLA class I - An attempt to prevent TRALI in patients. Transfus Apher Sci. 2024;63(4):103970.
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- 23. Alcorn K, Ramsey G, Souers R, Lehman CM. Appropriateness of plasma transfusion: a College of American Pathologists Q-probes study of guidelines, waste, and serious adverse events. Arch Pathol Lab Med. 2017;141(3):396-401.
- 24. Arslankoylu AE, Akbas B, Alakaya M, Bozlu G, Ozdemir AA. Relationship of Hemoglobin Concentration at Admission and Need for Erythroyte Transfusion During Hospitalization with Mortality in Pediatric Critical Care Patients [in Turkish]. J Pediatr Emerg Intensive Care Med. 2017;4(1):8-13.
- 25. Koç B, Yorulmaz A, Akyürek F, Yilmaz R. Determining the effects of erythrocyte suspension on total antioxidant status and total oxidative stress values in pediatric intensive care patients. Asian J Transfus Sci. 2024: DOI:10.4103/ajts.ajts_221_23.
- 26. New HV, Grant-Casey J, Lowe D, Kelleher A, Hennem S, Stanworth SJ. Red blood cell transfusion practice in children: current status and areas for improvement? A study of the use of red blood cell transfusions in children and infants. Transfusion. 2014;54(1):119-27.
- 27. Perrone PM, Milani GP, Dellepiane RM, Petaccia A, Prati D, Agostoni C, et al. Evaluation of Six Years of Appropriateness Level of Blood Transfusion in a Pediatric Ward. Int J Environ Res Public Health. 2023;20(3).
- 28. Borgert M, Binnekade J, Paulus F, Vroom M, Vlaar A, Goossens A, et al. Implementation of a transfusion bundle reduces inappropriate red blood cell transfusions in intensive care - a before and after study. Transfus Med. 2016;26(6):432-9.
- 29. Watson S, Kendrick K. Management of anaemia and blood transfusion in critical care - implementing national guidelines in ICU. BMJ Qual Improv Rep. 2014;3(1):u202106.w1109.
Üniversite Hastanesi Çocuk Yoğun Bakım Ünitesinde Eritrosit Süspansiyonu Transfüzyonu: Mevcut Yönergelere Ne kadar Uyulmaktadır?
Year 2024,
Volume: 12 Issue: 3, 77 - 82, 29.10.2024
Resul Yılmaz
,
Şeyma Işık Bedir
Abstract
Amaçlar. – Kan bileşeni transfüzyonu hastane yatışları sırasında kullanılan yaygın bir prosedürdür; ancak risksiz değildir. Kan ürünlerinin (BP) doğru kullanımının değerlendirilmesi, kullanımlarında ima edilen riskler ve maliyetler göz önünde bulundurulduğunda büyük önem taşır. Başlıca amacımız, üçüncü seviye bir üniversite hastanesinde pediatrik hastalarda eritrosit süspansiyonu (ES) transfüzyonu için uluslararası yönergelere uyumu değerlendirmekti.
Materyal ve yöntemler. – Pediatrik hastalarda (1 aydan 18 yaşına kadar) ES transfüzyonunun yanlış kullanımının sıklığını bildirmek için retrospektif tanımlayıcı analitik bir çalışma yürütüldü. 1 yıllık bir zaman diliminde, 155 tıbbi kayıt analiz edildi ve toplam 53 ES transfüzyonu çalışma örneği olarak seçildi. İncelenen değişkenler hacim, infüzyon süresi ve transfüzyon kriterleriydi. Endikasyonlar, uluslararası yönergelere göre hastanın tıbbi kayıtlarında değerlendirildi.
Sonuçlar. – Analiz edilen transfüzyonların %54'ü, esas olarak transfüzyon kriterlerinin karşılanmaması nedeniyle yanlış olarak sınıflandırıldı. Pediatrik hastalarda ES transfüzyon endikasyonları uluslararası kılavuzlara yeterince uymuyor.
Sonuç. – Mevcut kılavuzlara uyumu artırmak için ES transfüzyonlarının kullanımı hakkında eğitim ve bilgi için etkili programların uygulanması gerekiyor.
References
- 1. Özdemir N, Apak H. Çocuklarda kan transfüzyonunun temel ilkeleri Derleme. Türk Pediatri Arşivi. 2009;44(11):19-23.
- 2. Fortin S, Cardona LG, Latreille M, Tucci M, Lacroix J. Blood transfusion in acute and chronic pediatric settings: beliefs and practices. Transfusion. 2016;56(1):130-8.
- 3. Klein HG. Should blood be an essential medicine? N Engl J Med. 2013;368(3):199-201.
- 4. Negi G, Gaur DS, Kaur R. Blood transfusion safety: A study of adverse reactions at the blood bank of a tertiary care center. Adv Biomed Res. 2015;4:237.
- 5. Hopewell S, Omar O, Hyde C, Yu L-M, Doree C, Murphy MF. A systematic review of the effect of red blood cell transfusion on mortality: evidence from large-scale observational studies published between 2006 and 2010. BMJ Open. 2013;3(5):e002154.
- 6. Karam O, Russell RT, Stricker P, Vogel AM, Bateman ST, Valentine SL, et al. Recommendations on RBC Transfusion in Critically Ill Children With Nonlife-Threatening Bleeding or Hemorrhagic Shock From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018;19(9S Suppl 1):S127-s32.
- 7. New HV, Berryman J, Bolton-Maggs PH, Cantwell C, Chalmers EA, Davies T, et al. Guidelines on transfusion for fetuses, neonates and older children. Br J Haematol. 2016;175(5):784-828.
- 8. Carson JL, Grossman BJ, Kleinman S, Tinmouth AT, Marques MB, Fung MK, et al. Red blood cell transfusion: a clinical practice guideline from the AABB*. Ann Intern Med. 2012;157(1):49-58.
- 9. Surial B, Burkhart A, Terliesner N, Morgenthaler M, Bächli E. Adherence to transfusion guidelines: are we prepared for the Smarter Medicine or Choosing Wisely initiative? Swiss Med Wkly. 2015;145:w14084.
- 10. ERTUĞRUL ÖRÜÇ N, YENİCESU İ. ULUSAL KAN VE KAN BİLEŞENLERİ HAZIRLAMA, KULLANIM VE KALİTE GÜVENCESİ REHBERİ. In: Bakanlığı TS, editor. Ankara2016.
- 11. TÜRK EONATOLOJİ DERNEĞİ. KAN ÜRÜNLERİ TRANSFÜZYON REHBERİ 2021 GÜNCELLEMESİ. 2021.
- 12. Ozgonenel B, Nash TA, Rajpurkar M. Blood Components for Pediatric Transfusions. Pediatr Rev. 2020;41(5):259-61.
- 13. Villarreal-Martínez L, Cázares-Perales E, Domínguez-Varela I, Godoy-Salinas E, Villarreal-Martinez D, Gutiérrez-Fernández D, et al. Blood transfusion in children at a university hospital in a middle-income country: The need to reinforce adherence to current guidelines. Transfus Clin Biol. 2020;27(2):65-9.
- 14. Saldaña-Casas OF, De la Torre-Fernández A, Guzmán-García M, Blas-Mendiola C, Gómez-Gómez M, Saltigeral-Simental P. Blood component transfusions in a privated hospital for children. Rev Mex Pediatr. 2005;72(2):65-9.
- 15. Sharif M, Saxena A, Singh S, Manchala S, Jafri N. Blood Component Transfusion in a Tertiary Care Hospital. Indian J Pediatr. 2020;87(5):339-44.
- 16. Mokhtar G, Adly A, Baky AA, Ezzat D, Hakeem GA, Hassab H, et al. Transfusion of blood components in pediatric age groups: an evidence-based clinical practice guideline adapted for the use in Egypt using 'Adapted ADAPTE'. Ann Hematol. 2024;103(4):1373-88.
- 17. Dasararaju R, Marques MB. Adverse effects of transfusion. Cancer Control. 2015;22(1):16-25.
- 18. Nguyen NT, Titze TL, Nissen-Meyer LSH. Evaluation of transfusion reactions in patients following transfusion of blood components containing antibodies to HLA class I - An attempt to prevent TRALI in patients. Transfus Apher Sci. 2024;63(4):103970.
- 19. Natukunda B, Schonewille H, Smit Sibinga CT. Assessment of the clinical transfusion practice at a regional referral hospital in Uganda. Transfus Med. 2010;20(3):134-9.
- 20. Meléndez HJ, Zambrano MdP, Martínez X. Evaluación de adecuada indicación transfusional en un hospital universitario. Rev Colomb Anestesiol. 2007;35(3):195-201.
- 21. Malagón Martínez A, Berges-García A, Bonifaz-Gracias R, Bravo-Lindoro A. Guía para el uso clínico de la sangre. Asociación Mexicana de Medicina Transfusional. 2007.
- 22. Díaz MQ, Borobia AM, García Erce JA, Maroun-Eid C, Fabra S, Carcas A, et al. Appropriate use of red blood cell transfusion in emergency departments: a study in five emergency departments. Blood Transfus. 2017;15(3):199-206.
- 23. Alcorn K, Ramsey G, Souers R, Lehman CM. Appropriateness of plasma transfusion: a College of American Pathologists Q-probes study of guidelines, waste, and serious adverse events. Arch Pathol Lab Med. 2017;141(3):396-401.
- 24. Arslankoylu AE, Akbas B, Alakaya M, Bozlu G, Ozdemir AA. Relationship of Hemoglobin Concentration at Admission and Need for Erythroyte Transfusion During Hospitalization with Mortality in Pediatric Critical Care Patients [in Turkish]. J Pediatr Emerg Intensive Care Med. 2017;4(1):8-13.
- 25. Koç B, Yorulmaz A, Akyürek F, Yilmaz R. Determining the effects of erythrocyte suspension on total antioxidant status and total oxidative stress values in pediatric intensive care patients. Asian J Transfus Sci. 2024: DOI:10.4103/ajts.ajts_221_23.
- 26. New HV, Grant-Casey J, Lowe D, Kelleher A, Hennem S, Stanworth SJ. Red blood cell transfusion practice in children: current status and areas for improvement? A study of the use of red blood cell transfusions in children and infants. Transfusion. 2014;54(1):119-27.
- 27. Perrone PM, Milani GP, Dellepiane RM, Petaccia A, Prati D, Agostoni C, et al. Evaluation of Six Years of Appropriateness Level of Blood Transfusion in a Pediatric Ward. Int J Environ Res Public Health. 2023;20(3).
- 28. Borgert M, Binnekade J, Paulus F, Vroom M, Vlaar A, Goossens A, et al. Implementation of a transfusion bundle reduces inappropriate red blood cell transfusions in intensive care - a before and after study. Transfus Med. 2016;26(6):432-9.
- 29. Watson S, Kendrick K. Management of anaemia and blood transfusion in critical care - implementing national guidelines in ICU. BMJ Qual Improv Rep. 2014;3(1):u202106.w1109.