TR
EN
Gene Therapy and Current Therapeutic Approaches for Huntington's Disease
Öz
Huntington's disease (HD) is a progressive neurodegenerative disorder. ASOs and RNAi have shown significant promise in both experimental and clinical studies for the treatment of this disease. Additionally, researchers are investigating the precise alteration of the genome using CRISPR/Cas9 and base editing techniques. Potential treatment targets include reducing the levels of mutant Huntington's protein and halting the neurobiological processes that contribute to the development of HD. These therapeutic approaches hold the potential to enhance the overall well-being of individuals affected by the disease. As new gene silencing and editing tools continue to be developed, further advancements in HD treatment are expected. This review provides an overview of the current research on treatment strategies for HD.
Anahtar Kelimeler
Kaynakça
- Finkbeiner S. Huntington's disease. Cold Spring Harb Perspect Biol. 2011;3(6):a007476. Ramaswamy S, Kordower JH. Gene therapy for Huntington's disease. Neurobiology of disease. 2012;48(2):243-54. Muth CC. ASO therapy: hope for genetic neurological diseases. JAMA. 2018;319(7):644-6.
Ayrıntılar
Birincil Dil
İngilizce
Konular
Tıbbi Genetik (Kanser Genetiği hariç)
Bölüm
Derleme
Yayımlanma Tarihi
31 Aralık 2024
Gönderilme Tarihi
25 Ocak 2024
Kabul Tarihi
19 Aralık 2024
Yayımlandığı Sayı
Yıl 2024 Cilt: 1 Sayı: 4
APA
Özdem, B., & Saygılı, A. (2024). Gene Therapy and Current Therapeutic Approaches for Huntington’s Disease. Rize Tıp Dergisi, 1(4), 16-24. https://izlik.org/JA43AK34LN
AMA
1.Özdem B, Saygılı A. Gene Therapy and Current Therapeutic Approaches for Huntington’s Disease. RMJ. 2024;1(4):16-24. https://izlik.org/JA43AK34LN
Chicago
Özdem, Berna, ve Ayşenur Saygılı. 2024. “Gene Therapy and Current Therapeutic Approaches for Huntington’s Disease”. Rize Tıp Dergisi 1 (4): 16-24. https://izlik.org/JA43AK34LN.
EndNote
Özdem B, Saygılı A (01 Aralık 2024) Gene Therapy and Current Therapeutic Approaches for Huntington’s Disease. Rize Tıp Dergisi 1 4 16–24.
IEEE
[1]B. Özdem ve A. Saygılı, “Gene Therapy and Current Therapeutic Approaches for Huntington’s Disease”, RMJ, c. 1, sy 4, ss. 16–24, Ara. 2024, [çevrimiçi]. Erişim adresi: https://izlik.org/JA43AK34LN
ISNAD
Özdem, Berna - Saygılı, Ayşenur. “Gene Therapy and Current Therapeutic Approaches for Huntington’s Disease”. Rize Tıp Dergisi 1/4 (01 Aralık 2024): 16-24. https://izlik.org/JA43AK34LN.
JAMA
1.Özdem B, Saygılı A. Gene Therapy and Current Therapeutic Approaches for Huntington’s Disease. RMJ. 2024;1:16–24.
MLA
Özdem, Berna, ve Ayşenur Saygılı. “Gene Therapy and Current Therapeutic Approaches for Huntington’s Disease”. Rize Tıp Dergisi, c. 1, sy 4, Aralık 2024, ss. 16-24, https://izlik.org/JA43AK34LN.
Vancouver
1.Berna Özdem, Ayşenur Saygılı. Gene Therapy and Current Therapeutic Approaches for Huntington’s Disease. RMJ [Internet]. 01 Aralık 2024;1(4):16-24. Erişim adresi: https://izlik.org/JA43AK34LN
