Toll Benzeri Reseptörler’in Periodontal Hastalık Patogenezindeki Rolü

Abstract

Bağışıklık sistemi, doğal ve edinilmiş olmak üzere iki ana bölümden meydana gelir. Doğal bağışıklık sistemi, deri ve mukozal epitelyal bariyerler ile humoral ve hücresel elemanlardan oluşur. İlave olarak, konağın kendine yabancı olan patojenle ilgili molekülleri tanıması ve böylece bağışıklık yanıtın oluşturulmasını sağlayan çeşitli reseptörlere sahiptir. Bu reseptörlerden en iyi bilineni toll benzeri reseptör (TBR) ailesidir. Periodonsiyumun önemli bir savunma bileşeni olan dişeti epitel hücreleri oral mikroorganizmalar ile sürekli temas halindedir. Bu durum, dişeti epitelinde bulunan TBR'lerin sürekli olarak uyarılması ve devamında, ağız sağlığının korunmasına yardımcı olan sitokinlerin ve defensinlerin üretilmesi ile sonuçlanır. Diğer taraftan, konak ve mikroorganizma arasındaki bu dengenin mikroorganizma lehine bozulması sonucu periodontal dokulardaki hastalığın ilerlemesi artar. Bu derlemenin amacı doğal bağışıklık sistemin önemli elemanlarından biri olan TBR’lerin özelliklerini, sinyal iletimini, periodontal hastalıktaki rolünü ve epigenetik düzenlenmesini güncel yayınlar ışığında değerlendirmektir.

Keywords

• Toll benzeri reseptör
• periodontal
• hastalık

The Role of Toll-Like Receptors in the Pathogenesisis of Periodontal Disease

Abstract

Immune system consists of two main parts, named as innate and acquired. The innate immune system consists of skin and mucosal epithelial barriers and humoral and cellular elements. In addition, it has several receptors that allow the host to recognize pathogen related molecules, thereby creating an immune response. The best known of these receptors is the toll-like receptor (TLR) family. Gingival epithelial cells, which are an important defense component of the peridontium, always contact with oral microorganisms. This results in continuous stimulation of TLRs in the gingival epithelium and subsequent production of cytokines and defensins which helps to maintain oral health. On the other hand, as the balance between the host and the microorganism is distrupted in favor of the microorganism, the progression of periodontal breakdown increases. The purpose of this review is to evaluate the characteristics, signal transmission, active role in the pathogenesis of periodontal disease and the epigenetic regulation of TLRs, which are the important elements of the natural immune system, in the light of current publications.

Keywords

• Toll like receptor
• periodontal
• disease

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