Oftalmopatisiz Hipertiroidik Hastalarda Optik Cohorens Tomografi Bulguları

Abstract

Amaç: Bu çalışmada, hipertiroidi tanısı olan ve oftalmopati gelişmemiş hastalardaki koroid, retina ve peripapiller sinir lifi tabakasının kalınlığını ötiroid hasta grubuyla karşılaştırmak amaçlanmıştır. Gereç ve Yöntemler: Hastaların serum tiroid stimülan hormon (TSH), serbest T3 (fT3), serbest T4 (fT4) değerleri incelendi. Hipertiroidi semptomları ile başvuran ve tetkiklerinde TSH; 0,5 mu/L’nin altında saptanan olgular çalışmaya dahil edildi. Spektral domain optik koherens tomografi ile retina kalınlığı (RT), retina sinir lifi tabakası (RSLT) kalınlığı ve koroid kalınlığı (CT) hesaplandı. Bulgular: Çalışmaya 40’ı (%49) hipertiroidi hastası (HT), 42’si (%51) ötiroidik sağlıklı bireyler olmak üzere toplamda 82 kişi dahil edildi. RT ölçümleri açısından T500, T1000, T1500 ve N1500 değerlerinin HT grupta kontrol grubuna göre daha düşük olduğu olduğu ve bunların istatistiksel olarak anlamlı olduğu görüldü (sırasıyla p<0,001; p<0,001; p<0,001; p=0,011). CT ölçümleri açısından Central, N500, N1000 ve N1500, T500, T1000, T1500, HT grupta daha düşük olduğu ve bunların istatistiksel olarak anlamlı olduğu görüldü (sırasıyla p=0,003; p=0,002; p=0,005; p=0,005; p=0,002; p=0,002; p=0,028). RSLT ölçümleri açısından HT grubunda kontrol grubuna göre T, TS, TI segmentlerinde düşük, NI segmentinde yüksek olduğu ve bu farkın istatistiksel olarak anlamlı olduğu görüldü (sırasıyla p=0,008; p=0,001; p=0,002 ve p=0,009). Sonuç: Hipertiroidi tespit edilen hastalara, sadece oftalmopatisi olanlara değil oftalmopatisi olmayanlara da tanı konulduktan sonra düzenli göz kontrolleri yapılması gerektiği düşünülmüştür.

Keywords

• Hipertiroidi;
• retina kalınlığı;
• koroid kalınlığı;
• retina sinir lifi kalınlığı

Optic Coherence Tomography Findings in Hyperthyroid Patients without Ophthalmopathy

Abstract

Aim The aim of this study is to compare the choroidal, retinal, and peripapillary nerve fiber layer thickness of the patients diagnosed with hyperthyroidism but did not develop ophthalmopathy with the euthyroid patients. Material and Methods: Thyroid stimulating hormone (TSH), freeT3 (fT3) and freeT4 (fT4) tests of the patients were analyzed. Cases who came in with symptoms of hyperthyroidism and had a TSH lower than 0.5 mu/L were included to the study. Retinal thickness (RT), retinal nerve fiber layer (RNFL) thickness, and choroidal thickness (CT) were calculated by means of spectral domain optical coherence tomography. Results: A total of 82 participants, covering 40 (49%) hyperthyroid patients and 42 (51%) euthyroid healthy individuals, were examined. In terms of RT measurements, T500,T1000,T1500 and N1500 values were found to be lower in the HT group compared to the control group, and they were statistically significant (p<0.001; p<0.001; p<0.001; p=0.011;respectively). In terms of CT measurements, Central, N500,N1000 and N1500,T500,T1000,T1500 values were found to be lower in the HT group and they were statistically significant (p=0.003; p=0.002; p=0.005; p=0.005; p=0.002; p=0.002; p=0.028; respectively). In terms of RNFL measurements, T, TS, TI segments were found to be lower and NI segment was found to be higher in the HT group compared to the control group, and this difference was statistically significant (p=0.008; p=0.001; p=0.002 and p=0.009; respectively). Conclusion: As a result, it is advised to regularly perform eye controls of patients with hyperthyroidism, not only the ones with ophthalmopathy but also those without ophthalmopathy, after the diagnosis.

Keywords

• Hyperthyroid,
• retinal thickness;
• choroidal thickness;
• retinal nerve fiber thickness

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