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A case of Piperacillin Tazobactam Induced Febrile Neutropenia

Year 2024, Volume: 14 Issue: 2, 289 - 291, 22.05.2024
https://doi.org/10.33631/sabd.1339804

Abstract

Piperacillin-tazobactam is a beta-lactam group antibiotic that is frequently used in the treatment of many infectious diseases such as pneumonia, sepsis, intra-abdominal infections, and complicated skin and soft tissue infections. Side effects such as neutropenia, thrombocytopenia or pancytopenia may develop because of bone marrow suppression due to long-term PTZ use and high-dose PTZ use. This effect is a reversible and can be seen due to the use of all beta-lactam group antibiotics. Neutropenia is frequently observed because of bone marrow suppression, and thrombocytopenia usually accompanies the neutropenia. In this study, a case had a diagnosis of osteomyelitis and developed fever and neutropenia after the 21st day of piperacillin-tazobactam treatment is presented.

References

  • Seo YB, Lee J, Kim YK, Lee SS, Lee JA, Kim HY, et al. Randomized controlled trial of piperacillin-tazobactam, cefepime and ertapenem for the treatment of urinary tract infection caused by extended-spectrum beta-lactamase-producing Escherichia coli. BMC Infectious Diseases. 2017; 7(17): 404.
  • Ozguler M, Akbulut A. Uzun süreli piperasilin tazobaktam tedavisiyle görülen notropeni: İki olgu sunumu. Ankem Derg. 2014; 28(1): 37-40.
  • Neftel KA, Hauser SP, Müller MR. Inhibition of granulopoiesis in vivo and in vitro by beta-lactam antibiotics, J Infect Dis. 1985; 152(1): 90-8.
  • Lee KW, Chow KM, Chan NP, Lo AO, Szeto CC. Piperacillin/tazobactam induced myelosuppression J Clin Med Res. 2009; 1(1): 53-5.
  • Peralta FG, Sanchez MB, Roiz MP, Pena MA, Tejero MA, Arjona R. Incidence of neutropenia during treatment of bone-related infections with piperacillin-tazobactam. Clin Infect Dis. 2003; 37(11): 1568-72.
  • Benli A, Şimşek-Yavuz S, Başaran S, Çağatay A, Özsüt H, Eraksoy H. Hematologic Adverse Effects of Prolonged Piperacillin-Tazobactam Use in Adults. Turk J Haematol. 2018; 35(4): 290-5.
  • Demiraslan H, Gürbüz S, Tomul Z, Çelik İ. Piperacillin/Tazobactam-ınduced neutropenia: a case report. J Infect Microb Antimicrob. 2012; 1(1): 2.
  • Uzun G, Onem Y, Hatipoglu M, Turhan V, Mutluoglu M, Ay H. Piperacillin/tazobactam induced neutropenia, thrombocytopenia, and fever during treatment of a diabetic foot infection. Scand J Infect Dis. 2013; 45(1): 73-6.
  • Chen CC, Lin HA, Hung YJ, Chen JH. Piperacillin-tazobactam induced bicytopenia in low cumulative treatment doses. BMJ Case Rep. 2019; 12(12): e232944.
  • Uzun G, Mutluoğlu M, Ülçay A, Ay H, Memis A, Karakas A ve ark. Diyabetik ayak enfeksiyonu nedeniyle piperasilin/ tazobactam tedavisi alan hastalarda nötropeni insidansı: retrospektif kohort çalışma. Gülhane Tıp Derg. 2015; 57: 348-51.

Piperasilin Tazobaktama Bağlı Febril Nötropeni Olgusu

Year 2024, Volume: 14 Issue: 2, 289 - 291, 22.05.2024
https://doi.org/10.33631/sabd.1339804

Abstract

Piperasilin tazobaktam (PTZ), güçlü antipseudomonal etkinliğe sahip olan ve pnömoni, sepsis, intraabdominal enfeksiyonlar ve komplike deri, yumuşak doku enfeksiyonları gibi birçok enfeksiyon hastalığının tedavisinde sıklıkla kullanılan betalaktam grubu bir antibiyotiktir. Uzun süreli PTZ kullanımı ve yüksek doz PTZ kullanımına bağlı olarak kemik iliği baskılanması sonucu nötropeni, trombositopeni veya pansitopeni gibi yan etkiler gelişebilmektedir. Bu etki reversible bir yan etkidir ve bütün beta-laktam grubu antibiyotiklerin kullanımına bağlı görülebilmektedir. Kemik iliği baskılanması sonucu sıklıkla nötropeni görülmektedir ve genellikle trombositopeni tabloya eşlik etmektedir. Bu çalışmada osteomyelit tanısı ile takip edilen ve piperasilin-tazobaktam tedavisinin 21. gününden sonra ateş ve nötropeni gelişen bir olgu sunulmuştur.

References

  • Seo YB, Lee J, Kim YK, Lee SS, Lee JA, Kim HY, et al. Randomized controlled trial of piperacillin-tazobactam, cefepime and ertapenem for the treatment of urinary tract infection caused by extended-spectrum beta-lactamase-producing Escherichia coli. BMC Infectious Diseases. 2017; 7(17): 404.
  • Ozguler M, Akbulut A. Uzun süreli piperasilin tazobaktam tedavisiyle görülen notropeni: İki olgu sunumu. Ankem Derg. 2014; 28(1): 37-40.
  • Neftel KA, Hauser SP, Müller MR. Inhibition of granulopoiesis in vivo and in vitro by beta-lactam antibiotics, J Infect Dis. 1985; 152(1): 90-8.
  • Lee KW, Chow KM, Chan NP, Lo AO, Szeto CC. Piperacillin/tazobactam induced myelosuppression J Clin Med Res. 2009; 1(1): 53-5.
  • Peralta FG, Sanchez MB, Roiz MP, Pena MA, Tejero MA, Arjona R. Incidence of neutropenia during treatment of bone-related infections with piperacillin-tazobactam. Clin Infect Dis. 2003; 37(11): 1568-72.
  • Benli A, Şimşek-Yavuz S, Başaran S, Çağatay A, Özsüt H, Eraksoy H. Hematologic Adverse Effects of Prolonged Piperacillin-Tazobactam Use in Adults. Turk J Haematol. 2018; 35(4): 290-5.
  • Demiraslan H, Gürbüz S, Tomul Z, Çelik İ. Piperacillin/Tazobactam-ınduced neutropenia: a case report. J Infect Microb Antimicrob. 2012; 1(1): 2.
  • Uzun G, Onem Y, Hatipoglu M, Turhan V, Mutluoglu M, Ay H. Piperacillin/tazobactam induced neutropenia, thrombocytopenia, and fever during treatment of a diabetic foot infection. Scand J Infect Dis. 2013; 45(1): 73-6.
  • Chen CC, Lin HA, Hung YJ, Chen JH. Piperacillin-tazobactam induced bicytopenia in low cumulative treatment doses. BMJ Case Rep. 2019; 12(12): e232944.
  • Uzun G, Mutluoğlu M, Ülçay A, Ay H, Memis A, Karakas A ve ark. Diyabetik ayak enfeksiyonu nedeniyle piperasilin/ tazobactam tedavisi alan hastalarda nötropeni insidansı: retrospektif kohort çalışma. Gülhane Tıp Derg. 2015; 57: 348-51.
There are 10 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences (Other)
Journal Section Case Reports
Authors

Yasemin Çakır 0000-0001-5510-3216

Nevin Ince 0000-0002-0129-4536

Publication Date May 22, 2024
Submission Date August 8, 2023
Published in Issue Year 2024 Volume: 14 Issue: 2

Cite

Vancouver Çakır Y, Ince N. Piperasilin Tazobaktama Bağlı Febril Nötropeni Olgusu. VHS. 2024;14(2):289-91.