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Parkinson Hastalığı Rehabilitasyonunda Oyunla Rehabilitasyon Uygulamaları: Derleme

Year 2025, Volume: 5 Issue: 2, 109 - 119, 26.08.2025

Abstract

Parkinson hastalığı istirahat titremesi, rijidite, bradikinezi, postüral instabilite yürüme ve denge bozukluğu gibi motor problemler ile yorgunluk, kognitif etkilenimler, ağrı ve uyku bozukluğu gibi motor olmayan semptomlar gösteren, ilerleyici bir nörolojik hastalıktır. Fizyoterapi ve rehabilitasyon süreci, kişilerin motor kazanımlarının yanı sıra sosyal becerilerin artırılması, günlük yaşama dönüş hedefi ve dolaylı ya da doğrudan yaşam kalitesinin iyileştirilmesi amacıyla yürütülür. Oyunla egzersiz yöntemi oyun veya sanal gerçeklik uygulamalarının kuvvet, denge, koordinasyon veya kognitif amaçlarla hedefe uygun biçimlendirilerek kullanılmasını ifade eder. Sağlıklı bireylerde, sporcularda performans arttırma amacıyla kullanılan yöntem, rehabilitasyon amacıyla inme, Parkinson hastalığı, serebral palsi gibi farklı hasta popülasyon gruplarında yaygınlaşmaktadır. Parkinson hastalığında oyunla egzersiz, motor ve motor olmayan semptomların yönteminde kullanılabilecek, henüz yeni sayılabilecek bir yöntemdir. Denge, kognitif beceriler ve kas-iskelet sistemi üzerinde olumlu etkileri olabilecek uygulamalar hem evde telerehabilitasyon yöntemiyle hem de klinik ortamında tedavilerin çeşitlendirilmesi açısından değerlidir. Nörolojik rehabilitasyon sürecinde süreklilik ve motivasyon faktörleri dikkate alındığında, oyun egzersiz yöntemi geleneksel fizyoterapinin alternatifi ve/veya tamamlayıcısı olabilir.

References

  • Teulings HL, Contreras-Vidal JL, Stelmach GE, Adler CH. Parkinsonism reduces coordination of fingers, wrist, and arm in fine motor control. Exp Neurol. 1997;146(1):159-70.
  • Poewe W, Seppi K, Tanner CM, et al. Parkinson disease. Nat Rev Dis Primers. 2017;3:17013.
  • Jankovic J. Parkinson's disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry. 2008;79(4):368-76.
  • Saluja A, Goyal V, Dhamija RK. Multi-modal rehabilitation therapy in Parkinson's disease and related disorders. Ann Indian Acad Neurol. 2023;26(Suppl 1):S15-S25.
  • Petzinger GM, Fisher BE, McEwen S, Beeler JA, Walsh JP, Jakowec MW. Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease. Lancet Neurol. 2013;12(7):716-26.
  • da Silva PG, Domingues DD, de Carvalho LA, Allodi S, Correa CL. Neurotrophic factors in Parkinson's disease are regulated by exercise: Evidence-based practice. J Neurol Sci. 2016;363:5-15.
  • Tomlinson CL, Patel S, Meek C, et al. Physiotherapy intervention in Parkinson's disease: systematic review and meta-analysis. BMJ. 2012;345:e5004.
  • Domingos J, Keus SHJ, Dean J, de Vries NM, Ferreira JJ, Bloem BR. The european physiotherapy guideline for Parkinson's disease: Implications for neurologists. J Parkinsons Dis. 2018;8(4):499-502.
  • Lima LO, Scianni A, Rodrigues-de-Paula F. Progressive resistance exercise improves strength and physical performance in people with mild to moderate Parkinson's disease: a systematic review. J Physiother. 2013;59(1):7-13.
  • Chen W, Bang M, Krivonos D, Schimek H, Naval A. An immersive virtual reality exergame for people with Parkinson’s disease. In Computers Helping People with Special Needs, eds. Miesenberger K, Manduchi R, Covarrubias Rodriguez M, Penaz P. ICCHP 2020, Springer, 2020, 138 - 45.
  • Campo-Prieto P, Cancela-Carral JM, Rodríguez-Fuentes G. Wearable immersive virtual reality device for promoting physical activity in Parkinson’s disease patients. Sensors. 2022;22(9):3302.
  • Navarro-Lozano F, Kiper P, Carmona-Pérez C, Rutkowski S, Pinero-Pinto E, Luque-Moreno C. Effects of non-ımmersive virtual reality and video games on walking speed in Parkinson disease: A systematic review and meta-analysis. Journal of Clinical Medicine. 2022;11(22):6610.
  • Maggio MG, De Cola MC, Latella D, et al. What about the role of virtual reality in Parkinson disease's cognitive rehabilitation? Preliminary findings from a randomized clinical trial. J Geriatr Psychiatry Neurol. 2018;31(6):312-8.
  • Shahrbanian S, Ma X, Aghaei N, Korner-Bitensky N, Moshiri K, Simmonds MJ. Use of virtual reality (immersive vs. non immersive) for pain management in children and adults: A systematic review of evidence from randomized controlled trials. Eur J Exp Biol. 2012;2(5):1408-22.
  • Messier J, Adamovich S, Jack D, Hening W, Sage J, Poizner H. Visuomotor learning in immersive 3D virtual reality in Parkinson’s disease and in aging. Experimental Brain Research. 2007;179:457-74.
  • Bartsch T, Wulff P. The hippocampus in aging and disease: from plasticity to vulnerability. Neuroscience. 2015; 309:1-16.
  • Sleiman SF, Henry J, Al-Haddad R, et al. Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate. eLife. 2016;5:e15092.
  • Laar A, de Lima ALS, Maas B, Bloem BR, de Vries NM. Successful implementation of technology in the management of Parkinson's disease: Barriers and facilitators. Clinical Parkinsonism & Related Disorders. 2023:100188.
  • Kou R, Zhang Z, Zhu F, Tang Y, Li Z. Effects of Exergaming on executive function and motor ability in children: A systematic review and meta-analysis. PLoS One. 2024;19(9):e0309462.
  • Davis JC, G. KL, Matt GJ, S. WH, Renfroe LG. Exergaming for physical activity: A systematic review. J Am Coll Health. 2024;72(7):2090-8.
  • Pimenta Silva D, Bouça-Machado R, Pona-Ferreira F, et al. Combining immersive exergaming with physiotherapy in a specialized intensive Parkinson’s disease rehabilitation program: a randomized controlled trial. J Neuroeng Rehabil. 2025;22(1):131.
  • Mujber TS, Szecsi T, Hashmi MS. Virtual reality applications in manufacturing process simulation. Journal of Materials Processing Technology. 2004;155:1834-8.
  • Tsurayya G, Duta TF, Naufal MA, Alina M. Acceptance, safety, and impact on quality of life of exergame for elderly patients with neurodegenerative diseases: A systematic review and meta-analysis. Narra X. 2023;1(3):e94.
  • Elena P, Demetris S, Christina M, Marios P. Differences between exergaming rehabilitation and conventional physiotherapy on quality of life in Parkinson's disease: A systematic review and meta-analysis. Front Neurol. 2021; (12):683385.
  • Rytterström P, Strömberg A, Jaarsma T, Klompstra L. Exergaming to increase physical activity in older adults: feasibility and practical implications. Curr Heart Fail Rep. 2024;21(4):439-59.
  • Duncan RP, Earhart GM. Measuring participation in individuals with Parkinson disease: relationships with disease severity, quality of life, and mobility. Disability and Rehabilitation. 2011;33(15-16):1440-6.
  • Keus SH, Munneke M, Nijkrake MJ, Kwakkel G, Bloem BR. Physical therapy in Parkinson's disease: evolution and future challenges. Movement Disorders. 2009;24(1):1-14.
  • Abbruzzese G, Trompetto C, Marinelli L. The rationale for motor learning in Parkinson's disease. Eur J Phys Rehabil Med. 2009;45(2):209-14.
  • Pompeu JE, Arduini LA, Botelho AR, et al. Feasibility, safety and outcomes of playing Kinect Adventures! (TM) for people with Parkinson's disease: a pilot study. Physiotherapy. 2014;100(2):162-8.
  • Campo-Prieto P, Rodríguez-Fuentes G, Cancela-Carral JM. Can immersive virtual reality videogames help Parkinson’s disease patients? A case study. Sensors. 2021;21(14):4825.
  • Yun SJ, Hyun SE, Oh B-M, Seo HG. Fully immersive virtual reality exergames with dual-task components for patients with Parkinson’s disease: a feasibility study. J Neuroeng Rehabil. 2023;20(1):92.
  • Vellata C, Belli S, Balsamo F, Giordano A, Colombo R, Maggioni G. Effectiveness of telerehabilitation on motor ımpairments, non-motor symptoms and compliance in patients with Parkinson's disease: A systematic review. Front Neurol. 2021; (12): 627999.
  • Hardeman LES, Geerse DJ, Hoogendoorn EM, Nonnekes J, Roerdink M. Remotely prescribed, monitored, and tailored home-based gait-and-balance exergaming using augmented reality glasses: a clinical feasibility study in people with Parkinson’s disease. Front Neurol. 2024; (15): 1373740.
  • Hajebrahimi F, Velioglu HA, Bayraktaroglu Z, Helvaci Yilmaz N, Hanoglu L. Clinical evaluation and resting state fMRI analysis of virtual reality based training in Parkinson's disease through a randomized controlled trial. Sci Rep. 2022;12(1):8024.
  • Liao YY, Chen IH, Hsu WC, Tseng HY, Wang RY. Effect of exergaming versus combined exercise on cognitive function and brain activation in frail older adults: A randomised controlled trial. Ann Phys Rehabil Med. 2021;64(5):101492.
  • Schaeffer E, Roeben B, Granert O, et al. Effects of exergaming on hippocampal volume and brain-derived neurotrophic factor levels in Parkinson's disease. Eur J Neurol. 2022;29(2):441-9.
  • Mendes FAdS, Fidelis AL, D’Anna R, Collura G, Marrale M. Does exergaming promote neurofunctional changes in Parkinson’s disease? A pilot clinical study. Fisioterapia em Movimento. 2023;36:e36120.
  • Hajebrahimi F, Velioglu HA, Bayraktaroglu Z, Helvaci Yilmaz N, Hanoglu L. Clinical evaluation and resting state fMRI analysis of virtual reality based training in Parkinson’s disease through a randomized controlled trial. Sci Rep. 2022;12(1):8024.
  • Kafri M, Myslinski MJ, Gade VK, Deutsch JE. Energy expenditure and exercise intensity of interactive video gaming in individuals poststroke. Neurorehabilitation and Neural Repair. 2014;28(1):56-65.
  • Dockx K, Bekkers EM, Van den Bergh V, et al. Virtual reality for rehabilitation in Parkinson's disease Cochrane Database of Systematic Reviews 2016, Issue 12. Art. No.: CD010760. DOI: 10.1002/14651858.CD010760.pub2. Accessed 29 August 2025.
  • Prosperini L, Tomassini V, Castelli L, et al. Exergames for balance dysfunction in neurological disability: a meta-analysis with meta-regression. J Neurol. 2021;268(9):3223-37.
  • Rocha PS, de Sousa BBL, D'Amelio M, et al. Exergaming in the treatment of gait, balance, and quality of life in Parkinson's disease: Overview of systematic reviews. Physiother Res Int. 2023:e2002.
  • Brachman A, Marszalek W, Kamieniarz A, Michalska J, Pawlowski M, Juras G. Biomechanical measures of balance after balance-based exergaming training dedicated for patients with Parkinson's disease. Gait Posture. 2021;87:170-6.
  • Zhang J, Luximon Y, Pang MYC, Wang H. Effectiveness of exergaming-based interventions for mobility and balance performance in older adults with Parkinson's disease: systematic review and meta-analysis of randomised controlled trials. Age Ageing. 2022;51(8): afac175.
  • Marotta N, Demeco A, Indino A, de Scorpio G, Moggio L, Ammendolia A. Nintendo Wii (TM) versus Xbox Kinect (TM) for functional locomotion in people with Parkinson's disease: a systematic review and network meta-analysis. Disabil Rehabil. 2022;44(3):331-6.
  • Shahhar AZM, Qasheesh M, Shaphe MA. Effectiveness of nintendo wii on balance in people with Parkinson's disease: A systematic review. J Lifestyle Med. 2022;12(3):105-12.
  • Cikajlo I, Peterlin Potisk K. Advantages of using 3D virtual reality based training in persons with Parkinson’s disease: a parallel study. J Neuroeng Rehabil. 2019;16(1):119.
  • Cikajlo I, Hukic A, Dolinsek I, et al. Can telerehabilitation games lead to functional improvement of upper extremities in individuals with Parkinson's disease? Int J Rehabil Res. 2018;41(3):230-8.
  • Cikajlo I, Hukic A, Zajc D. Exergaming as part of the telerehabilitation can be adequate to the outpatient training: Preliminary findings of a non-randomized pilot study in Parkinson's disease. Front Neurol. 2021;12:625225.
  • Elena P, Demetris S, Christina M, Marios P. Differences between exergaming rehabilitation and conventional physiotherapy on quality of life in Parkinson's disease: A systematic review and meta-analysis. Front Neurol. 2021;12:683385.
  • Da Silva KG, Nuvolini RA, Bacha JMR, et al. Comparison of the effects of an exergame-based program with conventional physiotherapy protocol based on core areas of the european guideline on postural control, functional mobility, and quality of life in patients with Parkinson's disease: Randomized clinical trial. Games for Health Journal. 2023;12(3):228-41.
  • Pazzaglia C, Imbimbo I, Tranchita E, et al. Comparison of virtual reality rehabilitation and conventional rehabilitation in Parkinson’s disease: a randomised controlled trial. Physiotherapy. 2020;106:36-42.
  • Zhao N, Yang Y, Zhang L, et al. Quality of life in Parkinson's disease: A systematic review and meta-analysis of comparative studies. CNS Neurosci Ther. 2021;27(3):270-9.
  • Marotta N, Calafiore D, Curci C, et al. Integrating virtual reality and exergaming in cognitive rehabilitation of patients with Parkinson disease: a systematic review of randomized controlled trials. Eur J Phys Rehabil Med. 2022;58(6):818-26.
  • Schaeffer E, Busch JH, Roeben B, et al. Effects of exergaming on attentional deficits and dual-tasking in Parkinson's disease. Front Neurol. 2019;10:646.
  • Çetin B, Kılınç M, Çakmaklı GY. The effects of exergames on upper extremity performance, trunk mobility, gait, balance, and cognition in Parkinson’s disease: a randomized controlled study. Acta Neurol Belg. 2024;124(3):853-63.

Exergaming in Parkinson's Disease Rehabilitation: Narrative Review

Year 2025, Volume: 5 Issue: 2, 109 - 119, 26.08.2025

Abstract

Parkinson's disease is a progressive neurological disease that causes motor problems such as tremor, rigidity, bradykinesia, postural instability, gait and balance disorders, and non-motor symptoms such as fatigue, cognitive effects, pain and sleep disturbance. The physiotherapy and rehabilitation process is carried out with the aim of increasing people's motor skills as well as social skills, returning to daily life and indirectly or directly improving the quality of life. Exergaming method refers to the use of games or virtual reality applications in a targeted manner for strength, balance, coordination or cognitive purposes. The method, used for performance enhancement in healthy individuals and athletes is becoming widespread in different patient population groups such as stroke, Parkinson’s disease, cerebral palsy for rehabilitation purposes. Exergaming in Parkinson's disease is a relatively new method that can be used to treat motor and non-motor symptoms. Practices that may have positive effects on balance, cognitive skills and the musculoskeletal system are valuable in terms of diversifying treatments both at home through telerehabilitation and in the clinic environment. Considering continuity and motivation factors in the neurological rehabilitation process, exergaming can be an alternative and/or complement to traditional physiotherapy.

References

  • Teulings HL, Contreras-Vidal JL, Stelmach GE, Adler CH. Parkinsonism reduces coordination of fingers, wrist, and arm in fine motor control. Exp Neurol. 1997;146(1):159-70.
  • Poewe W, Seppi K, Tanner CM, et al. Parkinson disease. Nat Rev Dis Primers. 2017;3:17013.
  • Jankovic J. Parkinson's disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry. 2008;79(4):368-76.
  • Saluja A, Goyal V, Dhamija RK. Multi-modal rehabilitation therapy in Parkinson's disease and related disorders. Ann Indian Acad Neurol. 2023;26(Suppl 1):S15-S25.
  • Petzinger GM, Fisher BE, McEwen S, Beeler JA, Walsh JP, Jakowec MW. Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease. Lancet Neurol. 2013;12(7):716-26.
  • da Silva PG, Domingues DD, de Carvalho LA, Allodi S, Correa CL. Neurotrophic factors in Parkinson's disease are regulated by exercise: Evidence-based practice. J Neurol Sci. 2016;363:5-15.
  • Tomlinson CL, Patel S, Meek C, et al. Physiotherapy intervention in Parkinson's disease: systematic review and meta-analysis. BMJ. 2012;345:e5004.
  • Domingos J, Keus SHJ, Dean J, de Vries NM, Ferreira JJ, Bloem BR. The european physiotherapy guideline for Parkinson's disease: Implications for neurologists. J Parkinsons Dis. 2018;8(4):499-502.
  • Lima LO, Scianni A, Rodrigues-de-Paula F. Progressive resistance exercise improves strength and physical performance in people with mild to moderate Parkinson's disease: a systematic review. J Physiother. 2013;59(1):7-13.
  • Chen W, Bang M, Krivonos D, Schimek H, Naval A. An immersive virtual reality exergame for people with Parkinson’s disease. In Computers Helping People with Special Needs, eds. Miesenberger K, Manduchi R, Covarrubias Rodriguez M, Penaz P. ICCHP 2020, Springer, 2020, 138 - 45.
  • Campo-Prieto P, Cancela-Carral JM, Rodríguez-Fuentes G. Wearable immersive virtual reality device for promoting physical activity in Parkinson’s disease patients. Sensors. 2022;22(9):3302.
  • Navarro-Lozano F, Kiper P, Carmona-Pérez C, Rutkowski S, Pinero-Pinto E, Luque-Moreno C. Effects of non-ımmersive virtual reality and video games on walking speed in Parkinson disease: A systematic review and meta-analysis. Journal of Clinical Medicine. 2022;11(22):6610.
  • Maggio MG, De Cola MC, Latella D, et al. What about the role of virtual reality in Parkinson disease's cognitive rehabilitation? Preliminary findings from a randomized clinical trial. J Geriatr Psychiatry Neurol. 2018;31(6):312-8.
  • Shahrbanian S, Ma X, Aghaei N, Korner-Bitensky N, Moshiri K, Simmonds MJ. Use of virtual reality (immersive vs. non immersive) for pain management in children and adults: A systematic review of evidence from randomized controlled trials. Eur J Exp Biol. 2012;2(5):1408-22.
  • Messier J, Adamovich S, Jack D, Hening W, Sage J, Poizner H. Visuomotor learning in immersive 3D virtual reality in Parkinson’s disease and in aging. Experimental Brain Research. 2007;179:457-74.
  • Bartsch T, Wulff P. The hippocampus in aging and disease: from plasticity to vulnerability. Neuroscience. 2015; 309:1-16.
  • Sleiman SF, Henry J, Al-Haddad R, et al. Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate. eLife. 2016;5:e15092.
  • Laar A, de Lima ALS, Maas B, Bloem BR, de Vries NM. Successful implementation of technology in the management of Parkinson's disease: Barriers and facilitators. Clinical Parkinsonism & Related Disorders. 2023:100188.
  • Kou R, Zhang Z, Zhu F, Tang Y, Li Z. Effects of Exergaming on executive function and motor ability in children: A systematic review and meta-analysis. PLoS One. 2024;19(9):e0309462.
  • Davis JC, G. KL, Matt GJ, S. WH, Renfroe LG. Exergaming for physical activity: A systematic review. J Am Coll Health. 2024;72(7):2090-8.
  • Pimenta Silva D, Bouça-Machado R, Pona-Ferreira F, et al. Combining immersive exergaming with physiotherapy in a specialized intensive Parkinson’s disease rehabilitation program: a randomized controlled trial. J Neuroeng Rehabil. 2025;22(1):131.
  • Mujber TS, Szecsi T, Hashmi MS. Virtual reality applications in manufacturing process simulation. Journal of Materials Processing Technology. 2004;155:1834-8.
  • Tsurayya G, Duta TF, Naufal MA, Alina M. Acceptance, safety, and impact on quality of life of exergame for elderly patients with neurodegenerative diseases: A systematic review and meta-analysis. Narra X. 2023;1(3):e94.
  • Elena P, Demetris S, Christina M, Marios P. Differences between exergaming rehabilitation and conventional physiotherapy on quality of life in Parkinson's disease: A systematic review and meta-analysis. Front Neurol. 2021; (12):683385.
  • Rytterström P, Strömberg A, Jaarsma T, Klompstra L. Exergaming to increase physical activity in older adults: feasibility and practical implications. Curr Heart Fail Rep. 2024;21(4):439-59.
  • Duncan RP, Earhart GM. Measuring participation in individuals with Parkinson disease: relationships with disease severity, quality of life, and mobility. Disability and Rehabilitation. 2011;33(15-16):1440-6.
  • Keus SH, Munneke M, Nijkrake MJ, Kwakkel G, Bloem BR. Physical therapy in Parkinson's disease: evolution and future challenges. Movement Disorders. 2009;24(1):1-14.
  • Abbruzzese G, Trompetto C, Marinelli L. The rationale for motor learning in Parkinson's disease. Eur J Phys Rehabil Med. 2009;45(2):209-14.
  • Pompeu JE, Arduini LA, Botelho AR, et al. Feasibility, safety and outcomes of playing Kinect Adventures! (TM) for people with Parkinson's disease: a pilot study. Physiotherapy. 2014;100(2):162-8.
  • Campo-Prieto P, Rodríguez-Fuentes G, Cancela-Carral JM. Can immersive virtual reality videogames help Parkinson’s disease patients? A case study. Sensors. 2021;21(14):4825.
  • Yun SJ, Hyun SE, Oh B-M, Seo HG. Fully immersive virtual reality exergames with dual-task components for patients with Parkinson’s disease: a feasibility study. J Neuroeng Rehabil. 2023;20(1):92.
  • Vellata C, Belli S, Balsamo F, Giordano A, Colombo R, Maggioni G. Effectiveness of telerehabilitation on motor ımpairments, non-motor symptoms and compliance in patients with Parkinson's disease: A systematic review. Front Neurol. 2021; (12): 627999.
  • Hardeman LES, Geerse DJ, Hoogendoorn EM, Nonnekes J, Roerdink M. Remotely prescribed, monitored, and tailored home-based gait-and-balance exergaming using augmented reality glasses: a clinical feasibility study in people with Parkinson’s disease. Front Neurol. 2024; (15): 1373740.
  • Hajebrahimi F, Velioglu HA, Bayraktaroglu Z, Helvaci Yilmaz N, Hanoglu L. Clinical evaluation and resting state fMRI analysis of virtual reality based training in Parkinson's disease through a randomized controlled trial. Sci Rep. 2022;12(1):8024.
  • Liao YY, Chen IH, Hsu WC, Tseng HY, Wang RY. Effect of exergaming versus combined exercise on cognitive function and brain activation in frail older adults: A randomised controlled trial. Ann Phys Rehabil Med. 2021;64(5):101492.
  • Schaeffer E, Roeben B, Granert O, et al. Effects of exergaming on hippocampal volume and brain-derived neurotrophic factor levels in Parkinson's disease. Eur J Neurol. 2022;29(2):441-9.
  • Mendes FAdS, Fidelis AL, D’Anna R, Collura G, Marrale M. Does exergaming promote neurofunctional changes in Parkinson’s disease? A pilot clinical study. Fisioterapia em Movimento. 2023;36:e36120.
  • Hajebrahimi F, Velioglu HA, Bayraktaroglu Z, Helvaci Yilmaz N, Hanoglu L. Clinical evaluation and resting state fMRI analysis of virtual reality based training in Parkinson’s disease through a randomized controlled trial. Sci Rep. 2022;12(1):8024.
  • Kafri M, Myslinski MJ, Gade VK, Deutsch JE. Energy expenditure and exercise intensity of interactive video gaming in individuals poststroke. Neurorehabilitation and Neural Repair. 2014;28(1):56-65.
  • Dockx K, Bekkers EM, Van den Bergh V, et al. Virtual reality for rehabilitation in Parkinson's disease Cochrane Database of Systematic Reviews 2016, Issue 12. Art. No.: CD010760. DOI: 10.1002/14651858.CD010760.pub2. Accessed 29 August 2025.
  • Prosperini L, Tomassini V, Castelli L, et al. Exergames for balance dysfunction in neurological disability: a meta-analysis with meta-regression. J Neurol. 2021;268(9):3223-37.
  • Rocha PS, de Sousa BBL, D'Amelio M, et al. Exergaming in the treatment of gait, balance, and quality of life in Parkinson's disease: Overview of systematic reviews. Physiother Res Int. 2023:e2002.
  • Brachman A, Marszalek W, Kamieniarz A, Michalska J, Pawlowski M, Juras G. Biomechanical measures of balance after balance-based exergaming training dedicated for patients with Parkinson's disease. Gait Posture. 2021;87:170-6.
  • Zhang J, Luximon Y, Pang MYC, Wang H. Effectiveness of exergaming-based interventions for mobility and balance performance in older adults with Parkinson's disease: systematic review and meta-analysis of randomised controlled trials. Age Ageing. 2022;51(8): afac175.
  • Marotta N, Demeco A, Indino A, de Scorpio G, Moggio L, Ammendolia A. Nintendo Wii (TM) versus Xbox Kinect (TM) for functional locomotion in people with Parkinson's disease: a systematic review and network meta-analysis. Disabil Rehabil. 2022;44(3):331-6.
  • Shahhar AZM, Qasheesh M, Shaphe MA. Effectiveness of nintendo wii on balance in people with Parkinson's disease: A systematic review. J Lifestyle Med. 2022;12(3):105-12.
  • Cikajlo I, Peterlin Potisk K. Advantages of using 3D virtual reality based training in persons with Parkinson’s disease: a parallel study. J Neuroeng Rehabil. 2019;16(1):119.
  • Cikajlo I, Hukic A, Dolinsek I, et al. Can telerehabilitation games lead to functional improvement of upper extremities in individuals with Parkinson's disease? Int J Rehabil Res. 2018;41(3):230-8.
  • Cikajlo I, Hukic A, Zajc D. Exergaming as part of the telerehabilitation can be adequate to the outpatient training: Preliminary findings of a non-randomized pilot study in Parkinson's disease. Front Neurol. 2021;12:625225.
  • Elena P, Demetris S, Christina M, Marios P. Differences between exergaming rehabilitation and conventional physiotherapy on quality of life in Parkinson's disease: A systematic review and meta-analysis. Front Neurol. 2021;12:683385.
  • Da Silva KG, Nuvolini RA, Bacha JMR, et al. Comparison of the effects of an exergame-based program with conventional physiotherapy protocol based on core areas of the european guideline on postural control, functional mobility, and quality of life in patients with Parkinson's disease: Randomized clinical trial. Games for Health Journal. 2023;12(3):228-41.
  • Pazzaglia C, Imbimbo I, Tranchita E, et al. Comparison of virtual reality rehabilitation and conventional rehabilitation in Parkinson’s disease: a randomised controlled trial. Physiotherapy. 2020;106:36-42.
  • Zhao N, Yang Y, Zhang L, et al. Quality of life in Parkinson's disease: A systematic review and meta-analysis of comparative studies. CNS Neurosci Ther. 2021;27(3):270-9.
  • Marotta N, Calafiore D, Curci C, et al. Integrating virtual reality and exergaming in cognitive rehabilitation of patients with Parkinson disease: a systematic review of randomized controlled trials. Eur J Phys Rehabil Med. 2022;58(6):818-26.
  • Schaeffer E, Busch JH, Roeben B, et al. Effects of exergaming on attentional deficits and dual-tasking in Parkinson's disease. Front Neurol. 2019;10:646.
  • Çetin B, Kılınç M, Çakmaklı GY. The effects of exergames on upper extremity performance, trunk mobility, gait, balance, and cognition in Parkinson’s disease: a randomized controlled study. Acta Neurol Belg. 2024;124(3):853-63.
There are 56 citations in total.

Details

Primary Language Turkish
Subjects Physiotherapy, Rehabilitation
Journal Section Reviews
Authors

Tayfun Işık 0000-0001-8544-0336

Turhan Kahraman 0000-0002-8776-0664

Early Pub Date August 30, 2025
Publication Date August 26, 2025
Submission Date December 23, 2024
Acceptance Date August 26, 2025
Published in Issue Year 2025 Volume: 5 Issue: 2

Cite

Vancouver Işık T, Kahraman T. Parkinson Hastalığı Rehabilitasyonunda Oyunla Rehabilitasyon Uygulamaları: Derleme. Abant Sağlık Bilimleri ve Teknolojileri Dergisi. 2025;5(2):109-1.