ARALIKLI AÇLIK VE METABOLİK ETKİLERİ

Year 2022, Volume: 9 Issue: 1, 99 - 103, 01.03.2022

Açelya Gül Elvan Yılmaz Akyüz

Abstract

Giriş-Amaç: Aralıklı açlık, beslenme ve açlık dönemlerini içeren bir beslenme şeklidir. Alternatif gün açlıkları ve dini oruçlar aralıklı açlık modellerini oluşturur. Değiştirilmiş açlık ve zaman kısıtlı beslenme olarak uygulanan alternatif gün oruçları beslenme günleri ile açlık günlerinden oluşmaktadır. Aralıklı açlık, vücut kompozisyonunu ve bazı metabolik belirteçleri olumlu yönde değiştirme potansiyeline sahiptir, ancak uygulanan yönteme göre sonuçlar değişkenlik göstermektedir. Bu çalışmanın amacı aralıklı açlığın metabolik etkilerini ve bazı hastalıklardaki uygulama sonuçlarını incelemektir. Gereç-Yöntem: Pubmed, Science Direct, Web Of Science veri tabanlarında “aralıklı açlık, açlık, metabolik hastalıklar, obezite” anahtar kelimeleri kullanılarak güncel çalışmalar taranmıştır. Sonuç: Aralıklı açlık, obezite başta olmak üzere metabolik sendrom ve bazı diyabet türleri için potansiyel bir tedavi yöntemi olabilir. Obezite ve ilişkili bozuklukların insidansını azaltabilir. Vücut bileşimini iyileştirebilir, kardiyovasküler risk faktörlerini azaltabilir ve normogliseminin sağlanmasına yardımcı olabilir.

Keywords

Aralıklı açlık, Açlık, Metabolik Hastalıklar, Obezite

References

• Referans1 Mattson, M. P., Longo, V. D., & Harvie, M. (2017). Impact of intermittent fasting on health and disease processes. Ageing research reviews, 39, 46-58.
• Referans2 Patterson, R. E., Laughlin, G. A., LaCroix, A. Z., Hartman, S. J., Natarajan, L., Senger, C. M., ... & Gallo, L. C. (2015). Intermittent fasting and human metabolic health. Journal of the Academy of Nutrition and Dietetics, 115(8), 1203-1212.
• Referans3 Santos, H. O., & Macedo, R. C. (2018). Impact of intermittent fasting on the lipid profile: Assessment associated with diet and weight loss. Clinical nutrition ESPEN, 24, 14-21.
• Referans4 Zubrzyckı, A., et al., (2018), The role of low-calorie diets and intermittent fasting in the treatment of obesity and type-2 diabetes, J Physiol Pharmacol, 69.5: 663-683
• Referans5 Stockman, M. C., Thomas, D., Burke, J., & Apovian, C. M., (2018), Intermittent fasting: is the wait worth the weight?, Current obesity reports, 7(2), 172-185.
• Referans6 Persynaki, A., Karras, S., & Pichard, C. (2017). Unraveling the metabolic health benefits of fasting related to religious beliefs: A narrative review, Nutrition, 35, 14-20.
• Referans7 Bahijri, S. M., Ajabnoor, G. M., Borai, A., Al-Aama, J. Y., & Chrousos, G. P. (2015). Effect of Ramadan fasting in Saudi Arabia on serum bone profile and immunoglobulins, Therapeutic advances in endocrinology and metabolism, 6(5), 223-232.
• Referans8 Serin, Y., & Tek, N. A. (2019). Effect of circadian rhythm on metabolic processes and the regulation of energy balance. Annals of Nutrition and Metabolism, 74(4), 322-330.
• Referans9 Mo'ez Al-Islam, E. F., Jahrami, H. A., Obaideen, A. A., & Madkour, M. I. (2019). Impact of diurnal intermittent fasting during Ramadan on inflammatory and oxidative stress markers in healthy people: Systematic review and meta-analysis. Journal of Nutrition & Intermediary Metabolism, 15, 18-26.
• Referans10 Longo, V. D., & Panda, S. (2016). Fasting, circadian rhythms, and time-restricted feeding in healthy lifespan. Cell metabolism, 23(6), 1048-1059.
• Referans11 St-Onge, M. P., Mikic, A., & Pietrolungo, C. E. (2016). Effects of diet on sleep quality. Advances in nutrition, 7(5), 938-949.
• Referans12 Anton, S. D., Moehl, K., Donahoo, W. T., Marosi, K., Lee, S. A., Mainous III, A. G., ... & Mattson, M. P. (2018). Flipping the metabolic switch: understanding and applying the health benefits of fasting. Obesity, 26(2), 254-268.
• Referans13 Grajower, M. M., & Horne, B. D. (2019). Clinical management of intermittent fasting in patients with diabetes mellitus. Nutrients, 11(4), 873.
• Referans14 Rynders, C. A., Thomas, E. A., Zaman, A., Pan, Z., Catenacci, V. A., & Melanson, E. L. (2019). Effectiveness of intermittent fasting and time-restricted feeding compared to continuous energy restriction for weight loss. Nutrients, 11(10), 2442.
• Referans15 Sundfør, T. M., Svendsen, M., & Tonstad, S. (2018). Effect of intermittent versus continuous energy restriction on weight loss, maintenance and cardiometabolic risk: a randomized 1-year trial. Nutrition, Metabolism and Cardiovascular Diseases, 28(7), 698-706.
• Referans16 Gabel, K., Hoddy, K. K., Haggerty, N., Song, J., Kroeger, C. M., Trepanowski, J. F., ... & Varady, K. A. (2018). Effects of 8-hour time restricted feeding on body weight and metabolic disease risk factors in obese adults: A pilot study. Nutrition and healthy aging, 4(4), 345-353.
• Referans17 Alhamdan, B. A., Garcia‐Alvarez, A., Alzahrnai, A. H., Karanxha, J., Stretchberry, D. R., Contrera, K. J., ... & Cheskin, L. J. (2016). Alternate‐day versus daily energy restriction diets: which is more effective for weight loss? A systematic review and meta‐analysis. Obesity science & practice, 2(3), 293-302.
• Referans18 Gotthardt, J. D., Verpeut, J. L., Yeomans, B. L., Yang, J. A., Yasrebi, A., Roepke, T. A., & Bello, N. T. (2016). Intermittent fasting promotes fat loss with lean mass retention, increased hypothalamic norepinephrine content, and increased neuropeptide Y gene expression in diet-induced obese male mice. Endocrinology, 157(2), 679-691.
• Referans19 Byrne, N. M., Sainsbury, A., King, N. A., Hills, A. P., & Wood, R. E. (2018). Intermittent energy restriction improves weight loss efficiency in obese men: the MATADOR study. International journal of obesity, 42(2), 129-138.
• Referans20 Harvie, M., Wright, C., Pegington, M., McMullan, D., Mitchell, E., Martin, B., ... & Howell, A. (2013). The effect of intermittent energy and carbohydrate restriction v. daily energy restriction on weight loss and metabolic disease risk markers in overweight women. British Journal of Nutrition, 110(8), 1534-1547.
• Referans21 Sutton, E. F., Beyl, R., Early, K. S., Cefalu, W. T., Ravussin, E., & Peterson, C. M. (2018). Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes. Cell metabolism, 27(6), 1212-1221.
• Referans22 Furmli, S., Elmasry, R., Ramos, M., & Fung, J. (2018). Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulin. Case Reports, 2018, bcr-2017.
• Referans23 Carter, S., Clifton, P. M., & Keogh, J. B. (2018). Effect of intermittent compared with continuous energy restricted diet on glycemic control in patients with type 2 diabetes: a randomized noninferiority trial. JAMA network open, 1(3), e180756-e180756.
• Referans24 Galluzzi, L., Baehrecke, E. H., Ballabio, A., Boya, P., Bravo‐San Pedro, J. M., Cecconi, F., ... & Kroemer, G. (2017). Molecular definitions of autophagy and related processes. The EMBO journal, 36(13), 1811-1836.
• Referans25 Kaur, J., & Debnath, J. (2015). Autophagy at the crossroads of catabolism and anabolism. Nature reviews Molecular cell biology, 16(8), 461-472.
• Referans26 Amaravadi, R., Kimmelman, A. C., & White, E. (2016). Recent insights into the function of autophagy in cancer. Genes & development, 30(17), 1913-1930.
• Referans27 Sharifi, M. N., Mowers, E. E., Drake, L. E., Collier, C., Chen, H., Zamora, M., ... & Macleod, K. F. (2016). Autophagy promotes focal adhesion disassembly and cell motility of metastatic tumor cells through the direct interaction of paxillin with LC3. Cell reports, 15(8), 1660-1672.
• Referans28 O’Flanagan, C. H., Smith, L. A., McDonell, S. B., & Hursting, S. D. (2017). When less may be more: calorie restriction and response to cancer therapy. BMC medicine, 15(1), 1-9.
• Referans29 Antunes, F., Erustes, A. G., Costa, A. J., Nascimento, A. C., Bincoletto, C., Ureshino, R. P., & Smaili, S. S. (2018). Autophagy and intermittent fasting: the connection for cancer therapy?. Clinics, 73.
• Referans30 Caffa, I., D'Agostino, V., Damonte, P., Soncini, D., Cea, M., Monacelli, F., ... & Nencioni, A. (2015). Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition. Oncotarget, 6(14), 11820.