Diyabetik Makula Ödemi ile Diyet İleri Glikasyon Son Ürünleri (AGEs) ve Oksidatif Stres Arasındaki İlişkinin Değerlendirilmesi

Sedat Arslan; Dila Kırağı; Sibel Kadayıfçılar; Gülhan Samur

doi:10.25279/sak.757689

Diyabetik Makula Ödemi ile Diyet İleri Glikasyon Son Ürünleri (AGEs) ve Oksidatif Stres Arasındaki İlişkinin Değerlendirilmesi

Abstract

Giriş: Diyabetik makula ödemi (DMÖ), görme bozukluklarına ve körlüğe sebep olan bir hastalıktır. Kötü yönetilen diyabetin, retinopati komplikasyonu riski yüksektir. Diyetle glisemik kontrolü iyileştirmenin, diyabetik retinopatinin önlenmesinde etkili olduğu belirtilmiştir. Amaç: Bu çalışma, serum ileri glikasyon son ürünleri (AGEs), ileri glikasyon son ürünleri reseptörü (sRAGE) ve bireylerin diyet AGE (dAGE) alımları ile DMÖ hastalığı arasındaki ilişkiyi incelemek amacıyla yapılmıştır. Yöntem: Hacettepe Üniversitesi Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı’nda takip edilen DMÖ tanısı alan ve almayan toplam 90 diyabetli bireyin katılımıyla yapılmıştır. Bireylerin serumunda toplam antioksidan seviye (TAS), toplam oksidan seviye (TOS) ve ELISA yöntemiyle AGEs (karboksimetil lizin (CML)), sRAGE düzeyleri analiz edilmiştir. Ayrıca bireylerin besin tüketim kayıtları alınarak diyet AGEs alımı ve diyet glisemik indeksi/yükü hesaplanmıştır. Bulgular: DMÖ grubunun yaş ortalaması 62.6±8.4 ve kontrol grubunun yaş ortalaması 58.7±7.8 olarak belirlenmiştir. DMÖ grubunun AGEs düzeyleri ve diyet AGEs alımları kontrol grubuna göre istatistiksel olarak anlamlı düzeyde yüksek bulunmuştur (p<0,05). DMÖ grubunun sRAGE düzeyleri daha yüksek bulunmasına karşın bu fark istatistiksel olarak önemli bulunmamıştır (p>0,05). Vaka grubunun TOS değerleri ve oksidatif stres indeksi (OSİ) ortalamaları kontrol grubuna göre istatistiksel olarak anlamlı düzeyde yüksek bulunmuştur (p<0,001). Grupların diyet glisemik indeks ve glisemik yük ortalamaları arasında anlamlı bir fark bulunmamıştır (p>0.05). Vaka grubunda serum AGE ve sRAGE düzeyleri arasında pozitif yönde orta derecede korelasyon (p<0,001) bulunurken sRAGE ile TOS ve OSİ arasında negatif düşük derecede korelasyon saptanmıştır (p<0,05). Sonuç ve Öneriler: Bu çalışmada, DMÖ ile AGEs, dAGE, TOS, OSİ arasında pozitif ilişki bulunmuştur. Bu sonuçların geçerliliği için kontrollü beslenme müdahalelerini içeren çalışmalara gereksinim vardır.

Keywords

References

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Details

Primary Language

Turkish

Subjects

Nutrition and Dietetics

Journal Section

Research Article

Authors

Sedat Arslan ^*
0000-0002-3356-7332
Türkiye

Dila Kırağı This is me
0000-0002-0082-3467
Türkiye

Sibel Kadayıfçılar
0000-0002-5238-9535
Türkiye

Gülhan Samur
0000-0003-0456-4623
Türkiye

Publication Date

April 1, 2021

Submission Date

June 25, 2020

Acceptance Date

August 17, 2020

Published in Issue

Year 2021 Volume: 6 Number: 1

DOI

https://doi.org/10.25279/sak.757689

IZ

https://izlik.org/JA54XF27UP

Cite

RIS / Bibtex

APA

Arslan, S., Kırağı, D., Kadayıfçılar, S., & Samur, G. (2021). Diyabetik Makula Ödemi ile Diyet İleri Glikasyon Son Ürünleri (AGEs) ve Oksidatif Stres Arasındaki İlişkinin Değerlendirilmesi. Health Academy Kastamonu, 6(1), 1-22. https://doi.org/10.25279/sak.757689

AMA

1.Arslan S, Kırağı D, Kadayıfçılar S, Samur G. Diyabetik Makula Ödemi ile Diyet İleri Glikasyon Son Ürünleri (AGEs) ve Oksidatif Stres Arasındaki İlişkinin Değerlendirilmesi. HAK. 2021;6(1):1-22. doi:10.25279/sak.757689

Chicago

Arslan, Sedat, Dila Kırağı, Sibel Kadayıfçılar, and Gülhan Samur. 2021. “Diyabetik Makula Ödemi Ile Diyet İleri Glikasyon Son Ürünleri (AGEs) Ve Oksidatif Stres Arasındaki İlişkinin Değerlendirilmesi”. Health Academy Kastamonu 6 (1): 1-22. https://doi.org/10.25279/sak.757689.

EndNote

Arslan S, Kırağı D, Kadayıfçılar S, Samur G (April 1, 2021) Diyabetik Makula Ödemi ile Diyet İleri Glikasyon Son Ürünleri (AGEs) ve Oksidatif Stres Arasındaki İlişkinin Değerlendirilmesi. Health Academy Kastamonu 6 1 1–22.

IEEE

[1]S. Arslan, D. Kırağı, S. Kadayıfçılar, and G. Samur, “Diyabetik Makula Ödemi ile Diyet İleri Glikasyon Son Ürünleri (AGEs) ve Oksidatif Stres Arasındaki İlişkinin Değerlendirilmesi”, HAK, vol. 6, no. 1, pp. 1–22, Apr. 2021, doi: 10.25279/sak.757689.

ISNAD

Arslan, Sedat - Kırağı, Dila - Kadayıfçılar, Sibel - Samur, Gülhan. “Diyabetik Makula Ödemi Ile Diyet İleri Glikasyon Son Ürünleri (AGEs) Ve Oksidatif Stres Arasındaki İlişkinin Değerlendirilmesi”. Health Academy Kastamonu 6/1 (April 1, 2021): 1-22. https://doi.org/10.25279/sak.757689.

JAMA

1.Arslan S, Kırağı D, Kadayıfçılar S, Samur G. Diyabetik Makula Ödemi ile Diyet İleri Glikasyon Son Ürünleri (AGEs) ve Oksidatif Stres Arasındaki İlişkinin Değerlendirilmesi. HAK. 2021;6:1–22.

MLA

Arslan, Sedat, et al. “Diyabetik Makula Ödemi Ile Diyet İleri Glikasyon Son Ürünleri (AGEs) Ve Oksidatif Stres Arasındaki İlişkinin Değerlendirilmesi”. Health Academy Kastamonu, vol. 6, no. 1, Apr. 2021, pp. 1-22, doi:10.25279/sak.757689.

Vancouver

1.Sedat Arslan, Dila Kırağı, Sibel Kadayıfçılar, Gülhan Samur. Diyabetik Makula Ödemi ile Diyet İleri Glikasyon Son Ürünleri (AGEs) ve Oksidatif Stres Arasındaki İlişkinin Değerlendirilmesi. HAK. 2021 Apr. 1;6(1):1-22. doi:10.25279/sak.757689

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