Evaluation of the Effects of Periostin on Periodontal Tissues

Abstract

Periostin, a protein necessary for the integrity and maintenance of periodontal tissues; produced in collagen-rich connective tissues such as periodontal ligament (PDL), skeletal muscle, adipose tissue, tendons, skin, and alveolar bone. Based on structures where it is localized, the biological functions of the periostin have also been investigated in areas such as cardiovascular disorders and oncology. The periostin, which is highly secreted from the periodontal ligament, plays a critical role in the integrity of the periodontal tissues and in the development of teeth and bones. In addition that periostin is an effective protein in wound healing in periodontal tissues and preserving the integrity of periodontal tissues, and it leads the migration, adhesion, differentiation and intercellular connections of cells. In this review, it is aimed to evaluate the various functions of periostin on periodontal tissues.

Keywords

• Periostin
• Periodontium
• Periodontitis
• Periodontal Wound Healing

Periostinin Periodontal Dokular Üzerindeki Etkilerinin Değerlendirilmesi

Abstract

Periodontal dokuların bütünlüğünün sağlanması ve korunması için gerekli bir protein olan periostin; periodontal ligament (PDL), iskelet kası, adipoz doku, tendonlar, deri ve kemik gibi kolajenden zengin bağ dokularında üretilir. Lokalize olduğu yapılardan yola çıkılarak periostinin biyolojik fonksiyonları kardiyovasküler rahatsızlıklar ve onkoloji gibi alanlarda da incelenmiştir. Periodontal ligamentten yüksek oranda salgılanan periostin periodontal dokuların bütünlüğünde, diş ve alveoler kemik gelişiminde kritik rol oynar. İlaveten, periostin periodontal dokulardaki yara iyileşmesinde ve periodontal dokuların bütünlüğünü korumada etkin bir proteindir ve hücrelerin göçüne, adezyonuna, farklılaşmasına ve hücreler arası bağlantılara öncülük eder. Bu derlemede periostinin çeşitli fonksiyonlarının periodontal dokular üzerindeki etkisinin değerlendirilmesi amaçlanmıştır.

Keywords

• Periostin
• Periodonsiyum
• Periodontitis
• Periodontal Yara İyileşmesi

References

1. Bartold, P. M., & Narayanan, A. S. (2006). Molecular and cell biology of healthy and diseased periodontal tissues. Periodontology 2000, 40(1), 29-49 . Beertsen, W., McCulloch, C. A., & Sodek, J. (1997). The periodontal ligament: a unique, multifunctional connective tissue. Periodontology 2000, 13(1), 20-40.
2. Berkovitz, B. K. (2004). Periodontal ligament: structural and clinical correlates. Dental update, 31(1), 46-54 . Bornstein, P., & Sage, E. H. (2002). Matricellular proteins: extracellular modulators of cell function. Current opinion in cell biology, 14(5), 608-616.
3. Butcher, J. T., Norris, R. A., Hoffman, S., Mjaatvedt, C. H., & Markwald, R. R. (2007). Periostin promotes atrioventricular mesenchyme matrix invasion and remodeling mediated by integrin signaling through Rho/PI 3-kinase. Developmental biology, 302(1), 256-266.
4. Du, J., & Li, M. (2017). Functions of Periostin in dental tissues and its role in periodontal tissues’ regeneration. Cellular and molecular life sciences, 74(23), 4279-4286.
5. Esfahrood, Z. R., Vardian, S. T., Yadegari, Z., Adhim, M., & Saravi, N. S. V. (2018). Periostin levels in saliva of patients with chronic periodontitis. Journal of Indian Society of Periodontology, 22(1), 25.
6. Gillan, L., Matei, D., Fishman, D. A., Gerbin, C., Karlan, B. Y., & Chang, D. D. (2002). Periostin secreted by epithelial ovarian carcinoma is a ligand for αVβ3 and αVβ5 integrins and promotes cell motility. Cancer research, 62(18), 5358-5364.
7. Hamilton, D. W. Functional Role of Periostin Expression in Development and Wound Repair: Implications for Connective Tissue Disease. Hamilton, D. W. (2008). Functional role of periostin in development and wound repair: implications for connective tissue disease. Journal of cell communication and signaling, 2(1), 9-17.
8. Khurshid, Z., Mali, M., Adanir, N., Zafar, M. S., Khan, R. S., & Latif, M. (2020). Periostin: Immunomodulatory Effects on Oral Diseases. European Journal of Dentistry, 14(3), 462.

9. Kii, I., Nishiyama, T., Li, M., Matsumoto, K.-i., Saito, M., Amizuka, N., & Kudo, A. (2010). Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture. Journal of Biological Chemistry, 285(3), 2028-2039.
10. Kim, J.-E., Kim, S.-J., Lee, B.-H., Park, R.-W., Kim, K.-S., & Kim, I.-S. (2000). Identification of motifs for cell adhesion within the repeated domains of transforming growth factor-β-induced gene, βig-h3. Journal of Biological Chemistry, 275(40), 30907-30915. Kudo, A. (2011). Periostin in fibrillogenesis for tissue regeneration: periostin actions inside and outside the cell. Cellular and molecular life sciences, 68(19), 3201-3207.
11. Kudo, A. (2017). Introductory review: periostin—gene and protein structure. Cellular and molecular life sciences, 74(23), 4259-4268.
12. Kumaresan, D., Balasundaram, A., Naik, V. K., & Appukuttan, D. P. (2016). Gingival crevicular fluid periostin levels in chronic periodontitis patients following nonsurgical periodontal treatment with low-level laser therapy. European Journal of Dentistry, 10(04), 546-550.
13. Lindhe, J., Karring, T., & Lang, N. P. (2008). Clinical periodontology and implant dentistry; Volume 1+ 2: Blackwell.
14. Maruhashi, T., Kii, I., Saito, M., & Kudo, A. (2010). Interaction between periostin and BMP-1 promotes proteolytic activation of lysyl oxidase. Journal of Biological Chemistry, 285(17), 13294-13303.
15. Merle, B., & Garnero, P. (2012). The multiple facets of periostin in bone metabolism. Osteoporosis International, 23(4), 1199-1212.
16. Nakajima, M., Honda, T., Miyauchi, S., & Yamazaki, K. (2014). Th2 cytokines efficiently stimulate periostin production in gingival fibroblasts but periostin does not induce an inflammatory response in gingival epithelial cells. Archives of oral biology, 59(2), 93-101.
17. Padial-Molina, M., Marchesan, J. T., Taut, A. D., Jin, Q., Giannobile, W. V., & Rios, H. F. (2012). Methods to validate tooth-supporting regenerative therapies. In Odontogenesis (pp. 135-148): Springer.
18. Padial‐Molina, M., Volk, S., & Rios, H. (2014). Periostin increases migration and proliferation of human periodontal ligament fibroblasts challenged by tumor necrosis factor‐α and Porphyromonas gingivalis lipopolysaccharides. Journal of periodontal research, 49(3), 405-414.
19. Padial‐Molina, M., Volk, S. L., & Rios, H. F. (2015). Preliminary insight into the periostin leverage during periodontal tissue healing. Journal of Clinical Periodontology, 42(8), 764-772.
20. Savage, A., Eaton, K. A., Moles, D. R., & Needleman, I. (2009). A systematic review of definitions of periodontitis and methods that have been used to identify this disease. Journal of Clinical Periodontology, 36(6), 458-467.
21. Schroeder, H. E. (2012). The periodontium (Vol. 5): Springer Science & Business Media.
22. Shimazaki, M., Nakamura, K., Kii, I., Kashima, T., Amizuka, N., Li, M., . . . Kitajima, S. (2008). Periostin is essential for cardiac healingafter acute myocardial infarction. The Journal of experimental medicine, 205(2), 295-303.
23. Suzuki, H., Amizuka, N., Kii, I., Kawano, Y., Nozawa‐Inoue, K., Suzuki, A., . . . Maeda, T. (2004). Immunohistochemical localization of periostin in tooth and its surrounding tissues in mouse mandibles during development. The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology: An Official Publication of the American Association of Anatomists, 281(2), 1264-1275.
24. Tanabe, H., Takayama, I., Nishiyama, T., Shimazaki, M., Kii, I., Li, M., . . . Kudo, A. (2010). Periostin associates with Notch1 precursor to maintain Notch1 expression under a stress condition in mouse cells. PLoS One, 5(8), e12234.
25. Walker, J. T., McLeod, K., Kim, S., Conway, S. J., & Hamilton, D. W. (2016). Periostin as a multifunctional modulator of the wound healing response. Cell and tissue research, 365(3), 453-465.
26. Wang, J., Massoudi, D., Ren, Y., Muir, A., Harris, S., Greenspan, D., & Feng, J. (2017). BMP1 and TLL1 are required for maintaining periodontal homeostasis. Journal of dental research, 96(5), 578-585.