Diyabetik Makula Ödemi ile Diyet İleri Glikasyon Son Ürünleri (AGEs) ve Oksidatif Stres Arasındaki İlişkinin Değerlendirilmesi

Year 2021, Volume: 6 Issue: 1, 1 - 22, 01.04.2021

Sedat Arslan Dila Kırağı Sibel Kadayıfçılar Gülhan Samur

https://doi.org/10.25279/sak.757689

Cited By: 2

Abstract

Giriş: Diyabetik makula ödemi (DMÖ), görme bozukluklarına ve körlüğe sebep olan bir hastalıktır. Kötü yönetilen diyabetin, retinopati komplikasyonu riski yüksektir. Diyetle glisemik kontrolü iyileştirmenin, diyabetik retinopatinin önlenmesinde etkili olduğu belirtilmiştir. Amaç: Bu çalışma, serum ileri glikasyon son ürünleri (AGEs), ileri glikasyon son ürünleri reseptörü (sRAGE) ve bireylerin diyet AGE (dAGE) alımları ile DMÖ hastalığı arasındaki ilişkiyi incelemek amacıyla yapılmıştır. Yöntem: Hacettepe Üniversitesi Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı’nda takip edilen DMÖ tanısı alan ve almayan toplam 90 diyabetli bireyin katılımıyla yapılmıştır. Bireylerin serumunda toplam antioksidan seviye (TAS), toplam oksidan seviye (TOS) ve ELISA yöntemiyle AGEs (karboksimetil lizin (CML)), sRAGE düzeyleri analiz edilmiştir. Ayrıca bireylerin besin tüketim kayıtları alınarak diyet AGEs alımı ve diyet glisemik indeksi/yükü hesaplanmıştır. Bulgular: DMÖ grubunun yaş ortalaması 62.6±8.4 ve kontrol grubunun yaş ortalaması 58.7±7.8 olarak belirlenmiştir. DMÖ grubunun AGEs düzeyleri ve diyet AGEs alımları kontrol grubuna göre istatistiksel olarak anlamlı düzeyde yüksek bulunmuştur (p<0,05). DMÖ grubunun sRAGE düzeyleri daha yüksek bulunmasına karşın bu fark istatistiksel olarak önemli bulunmamıştır (p>0,05). Vaka grubunun TOS değerleri ve oksidatif stres indeksi (OSİ) ortalamaları kontrol grubuna göre istatistiksel olarak anlamlı düzeyde yüksek bulunmuştur (p<0,001). Grupların diyet glisemik indeks ve glisemik yük ortalamaları arasında anlamlı bir fark bulunmamıştır (p>0.05). Vaka grubunda serum AGE ve sRAGE düzeyleri arasında pozitif yönde orta derecede korelasyon (p<0,001) bulunurken sRAGE ile TOS ve OSİ arasında negatif düşük derecede korelasyon saptanmıştır (p<0,05). Sonuç ve Öneriler: Bu çalışmada, DMÖ ile AGEs, dAGE, TOS, OSİ arasında pozitif ilişki bulunmuştur. Bu sonuçların geçerliliği için kontrollü beslenme müdahalelerini içeren çalışmalara gereksinim vardır.

Keywords

Maküla ödemi, Diyabet komplikasyonları, İleri glikasyon son ürünleri, Beslenme, Antioksidanlar

References

• Alberg, A. J. (2002). The influence of cigarette smoking on circulating concentrations of antioxidant micronutrients. Toxicology, 180(2), 121-137.
• Antonetti, D. A., Lieth, E., Barber, A. J., & Gardner, T. W. (1999). Molecular mechanisms of vascular permeability in diabetic retinopathy. Paper presented at the Seminars in Ophthalmology.
• Arai, K., Maguchi, S., Fujii, S., Ishibashi, H., Oikawa, K., & Taniguchi, N. (1987). Glycation and inactivation of human Cu-Zn-superoxide dismutase. Identification of the in vitro glycated sites. Journal of biological chemistry, 262(35), 16969-16972.
• Atkinson, F. S., Foster-Powell, K., & Brand-Miller, J. C. (2008). International tables of glycemic index and glycemic load values: 2008. Diabetes care, 31(12), 2281-2283.
• Basaga, H. (1990). Biochemical aspects of free radicals. Biochemistry and Cell Biology, 68(7-8), 989-998.
• Basta, G., Del Turco, S., Navarra, T., Mazzarisi, A., Cocci, F., Coceani, M., . . . Marraccini, P. (2012). Inverse association between circulating levels of soluble receptor for advanced glycation end-products and coronary plaque burden. Journal of Atherosclerosis and Thrombosis, 10561.
• Boniol, M., Dragomir, M., Autier, P., & Boyle, P. (2017). Physical activity and change in fasting glucose and HbA1c: a quantitative meta-analysis of randomized trials. Acta Diabetologica, 54(11), 983-991.
• Cai, W., Ramdas, M., Zhu, L., Chen, X., Striker, G. E., & Vlassara, H. (2012). Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1. Proceedings of the National Academy of Sciences, 109(39), 15888-15893.
• Carlsen, M. H., Halvorsen, B. L., Holte, K., Bøhn, S. K., Dragland, S., Sampson, L., . . . Sanada, C. (2010). The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide. Nutrition journal, 9(1), 3.
• Chiu, C.-J., & Taylor, A. (2011). Dietary hyperglycemia, glycemic index and metabolic retinal diseases. Progress in retinal and eye research, 30(1), 18-53.
• Cohen, S. R., & Gardner, T. W. (2016). Diabetic retinopathy and diabetic macular edema. In Retinal Pharmacotherapeutics (Vol. 55, pp. 137-146): Karger Publishers.
• Colhoun, H. M., Betteridge, D. J., Durrington, P., Hitman, G., Neil, A., Livingstone, S., . . . Preston, G. M. (2011). Total soluble and endogenous secretory receptor for advanced glycation end products as predictive biomarkers of coronary heart disease risk in patients with type 2 diabetes: an analysis from the CARDS trial. Diabetes, 60(9), 2379-2385.
• Di Pino, A., Currenti, W., Urbano, F., Mantegna, C., Purrazzo, G., Piro, S., . . . Rabuazzo, A. M. (2016). Low advanced glycation end product diet improves the lipid and inflammatory profiles of prediabetic subjects. Journal of Clinical Lipidology, 10(5), 1098-1108.
• Ding, Q., & Keller, J. N. (2005). Evaluation of rage isoforms, ligands, and signaling in the brain. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1746(1), 18-27.
• Erel, O. (2004). A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clinical biochemistry, 37(4), 277-285.
• Erel, O. (2005). A new automated colorimetric method for measuring total oxidant status. Clinical biochemistry, 38(12), 1103-1111.
• Falcone, C., Emanuele, E., D’Angelo, A., Buzzi, M. P., Belvito, C., Cuccia, M., & Geroldi, D. (2005). Plasma levels of soluble receptor for advanced glycation end products and coronary artery disease in nondiabetic men. Arteriosclerosis, thrombosis, and vascular biology, 25(5), 1032-1037.
• Fosmark, D. S., Torjesen, P. A., Kilhovd, B. K., Berg, T. J., Sandvik, L., Hanssen, K. F., . . . Agardh, E. (2006). Increased serum levels of the specific advanced glycation end product methylglyoxal-derived hydroimidazolone are associated with retinopathy in patients with type 2 diabetes mellitus. Metabolism, 55(2), 232-236.
• Goldin, A., Beckman, J. A., Schmidt, A. M., & Creager, M. A. (2006). Advanced glycation end products: sparking the development of diabetic vascular injury. Circulation, 114(6), 597-605.
• Gu, K., Cowie, C. C., & Harris, M. I. (1998). Mortality in adults with and without diabetes in a national cohort of the US population, 1971–1993. Diabetes care, 21(7), 1138-1145.
• H. Ü. Beslenme & D. Bölümü, (2015). Türkiye’ye Özgü Besin ve Beslenme Rehberi (TÖBR). Hacettepe Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü. Yenilenmiş, 1.
• Hammes, H.-P., Alt, A., Niwa, T., Clausen, J., Bretzel, R., Brownlee, M., & Schleicher, E. (1999). Differential accumulation of advanced glycation end products in the course of diabetic retinopathy. Diabetologia, 42(6), 728-736.
• Hayran, M. (2011). Sağlık araştırmaları için temel istatistik: Omega Araştırma.
• Heidland, A., Sebekova, K., & Schinzel, R. (2001). Advanced glycation end products and the progressive course of renal disease. American Journal of Kidney Diseases, 38(4), S100-S106.
• Henricsson, M., Nilsson, A., Janzon, L., & Groop, L. (1997). The effect of glycaemic control and the introduction of insulin therapy on retinopathy in non‐insulin‐dependent diabetes mellitus. Diabetic Medicine, 14(2), 123-131.
• Hofmann, S. M., Dong, H.-J., Li, Z., Cai, W., Altomonte, J., Thung, S. N., . . . Vlassara, H. (2002). Improved insulin sensitivity is associated with restricted intake of dietary glycoxidation products in the db/db mouse. Diabetes, 51(7), 2082-2089.
• Joint, F.A.O., & World Health Organization. (1998). Preparation and use of food-based dietary guidelines: World Health Organization.
• Kanwar, M., Chan, P.-S., Kern, T. S., & Kowluru, R. A. (2007). Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase. Investigative ophthalmology & visual science, 48(8), 3805-3811.
• Katakami, N., Matsuhisa, M., Kaneto, H., Matsuoka, T.-a., Sakamoto, K. y., Nakatani, Y., . . . Hori, M. (2005). Decreased endogenous secretory advanced glycation end product receptor in type 1 diabetic patients: its possible association with diabetic vascular complications. Diabetes care, 28(11), 2716-2721.
• Klein, R., Klein, B. E., & Davis, M. D. (1983). Is cigarette smoking associated with diabetic retinopathy? American journal of epidemiology, 118(2), 228-238.
• Klein, R., Klein, B. E., Moss, S. E., Davis, M. D., & DeMets, D. L. (1984). The Wisconsin Epidemiologic Study of Diabetic Retinopathy: II. Prevalence and risk of diabetic retinopathy when age at diagnosis is less than 30 years. Archives of ophthalmology, 102(4), 520-526.
• Klein, R., Knudtson, M. D., Lee, K. E., Gangnon, R., & Klein, B. E. (2008). The Wisconsin Epidemiologic Study of Diabetic Retinopathy XXII: the twenty-five-year progression of retinopathy in persons with type 1 diabetes. Ophthalmology, 115(11), 1859-1868.
• Klein, R., Knudtson, M. D., Lee, K. E., Gangnon, R., & Klein, B. E. (2009). The Wisconsin Epidemiologic Study of Diabetic Retinopathy XXIII: the twenty-five-year incidence of macular edema in persons with type 1 diabetes. Ophthalmology, 116(3), 497-503.
• Kowluru, R. (2001). Diabetes-induced elevations in retinal oxidative stress, protein kinase C and nitric oxide are interrelated. Acta Diabetologica, 38(4), 179-185.
• Kowluru, R. A., Tang, J., & Kern, T. S. (2001). Abnormalities of retinal metabolism in diabetes and experimental galactosemia: VII. Effect of long-term administration of antioxidants on the development of retinopathy. Diabetes, 50(8), 1938-1942.
• Koyama, H., Yamamoto, H., & Nishizawa, Y. (2007). RAGE and soluble RAGE: potential therapeutic targets for cardiovascular diseases. Molecular medicine, 13(11-12), 625-635.
• Leasher, J., Bourne, R., Flaxman, S., Jonas, J., Keeffe, J., Naidoo, K., . . . Wong, T. (2016). Vision Loss Expert Group of the Global Burden of Disease Study Global estimates on the number of people blind or visually impaired by diabetic retinopathy: a meta-analysis from 1990 to 2010. Diabetes care, 39(9), 1643-1649.
• Monnier, V. M., & Cerami, A. (1981). Nonenzymatic browning in vivo: possible process for aging of long-lived proteins. Science, 211(4481), 491-493.
• Moss, S. E., Klein, R., & Klein, B. E. (1991). Association of cigarette smoking with diabetic retinopathy. Diabetes care, 14(2), 119-126. Moss, S. E., Klein, R., & Klein, B. E. (1996). Cigarette smoking and ten-year progression of diabetic retinopathy. Ophthalmology, 103(9), 1438-1442.
• Mühlhauser, I., Sawicki, P., & Berger, M. (1986). Cigarette-smoking as a risk factor for macroproteinuria and proliferative retinopathy in type I (insulin-dependent) diabetes. Diabetologia, 29(8), 500-502.
• Münch, G., Schicktanz, D., Behme, A., Gerlach, M., Riederer, P., Palm, D., & Schinzel, R. (1999). Amino acid specificity of glycation and protein–AGE crosslinking reactivities determined with a dipeptide SPOT library. Nature biotechnology, 17(10), 1006-1010.
• Nakamura, K., Yamagishi, S. i., Adachi, H., Kurita‐Nakamura, Y., Matsui, T., Yoshida, T., . . . Imaizumi, T. (2007). Elevation of soluble form of receptor for advanced glycation end products (sRAGE) in diabetic subjects with coronary artery disease. Diabetes/metabolism research and reviews, 23(5), 368-371.
• Nguyen-Khoa, B.-A., Goehring, E. L., Werther, W., Fung, A. E., Do, D. V., Apte, R. S., & Jones, J. K. (2012). Hospitalized cardiovascular events in patients with diabetic macular edema. BMC Ophthalmology, 12(1), 11.
• Nowotny, K., Jung, T., Grune, T., & Höhn, A. (2014). Reprint of “Accumulation of modified proteins and aggregate formation in aging”. Experimental gerontology, 59, 3-12.
• Nowotny, K., Jung, T., Höhn, A., Weber, D., & Grune, T. (2015). Advanced glycation end products and oxidative stress in type 2 diabetes mellitus. Biomolecules, 5(1), 194-222.
• Nowotny, K., Schröter, D., Schreiner, M., & Grune, T. (2018). Dietary advanced glycation end products and their relevance for human health. Ageing research reviews, 47, 55-66.
• Ogurtsova, K., da Rocha Fernandes, J., Huang, Y., Linnenkamp, U., Guariguata, L., Cho, N. H., . . . Makaroff, L. (2017). IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes research and clinical practice, 128, 40-50.
• Oliver, C. M., Melton, L. D., & Stanley, R. A. (2006). Creating proteins with novel functionality via the Maillard reaction: a review. Critical reviews in food science and nutrition, 46(4), 337-350.
• Ono, Y., Aoki, S., Ohnishi, K., Yasuda, T., Kawano, K., & Tsukada, Y. (1998). Increased serum levels of advanced glycation end-products and diabetic complications. Diabetes research and clinical practice, 41(2), 131-137.
• Poulsen, M. W., Hedegaard, R. V., Andersen, J. M., de Courten, B., Bügel, S., Nielsen, J., . . . Dragsted, L. O. (2013). Advanced glycation endproducts in food and their effects on health. Food and Chemical Toxicology, 60, 10-37.
• Prasad, C., Imrhan, V., Marotta, F., Juma, S., & Vijayagopal, P. (2014). Lifestyle and advanced glycation end products (AGEs) burden: its relevance to healthy aging. Aging and disease, 5(3), 212.
• Rakıcıoğlu, N., Tek Acar, N., Ayaz, A., & Pekcan, G. (2009). Yemek ve besin fotoğraf kataloğu ölçü ve miktarlar. Ankara: Ata Ofset Matbaacılık.
• Rogers, S., McIntosh, R. L., Cheung, N., Lim, L., Wang, J. J., Mitchell, P., . . . Consortium, I. E. D. (2010). The prevalence of retinal vein occlusion: pooled data from population studies from the United States, Europe, Asia, and Australia. Ophthalmology, 117(2), 313-319. e311.
• Satman, I., Omer, B., Tutuncu, Y., Kalaca, S., Gedik, S., Dinccag, N., . . . Canbaz, B. (2013). Twelve-year trends in the prevalence and risk factors of diabetes and prediabetes in Turkish adults. European journal of epidemiology, 28(2), 169-180.
• Selek, S., Aslan, M., Horoz, M., Gur, M., & Erel, O. (2007). Oxidative status and serum PON1 activity in beta-thalassemia minor. Clinical biochemistry, 40(5-6), 287-291.
• Stitt, A. W. (2003). The role of advanced glycation in the pathogenesis of diabetic retinopathy. Experimental and Molecular Pathology, 75(1), 95-108.
• Stitt, A. W., Li, Y. M., Gardiner, T. A., Bucala, R., Archer, D. B., & Vlassara, H. (1997). Advanced glycation end products (AGEs) co-localize with AGE receptors in the retinal vasculature of diabetic and of AGE-infused rats. The American journal of pathology, 150(2), 523.
• Suarez-Pinzon, W. L., Szabó, C., & Rabinovitch, A. (1997). Development of autoimmune diabetes in NOD mice is associated with the formation of peroxynitrite in pancreatic islet β-cells. Diabetes, 46(5), 907-911.
• Sugiyama, S., Miyata, T., Ueda, Y., Tanaka, H., Maeda, K., Kawashima, S., . . . Kurokawa, K. (1998). Plasma levels of pentosidine in diabetic patients: an advanced glycation end product. Journal of the American Society of Nephrology, 9(9), 1681-1688.
• Tarr, J. M., Kaul, K., Chopra, M., Kohner, E. M., & Chibber, R. (2013). Pathophysiology of diabetic retinopathy. ISRN Ophthalmol, 2013, 343560. doi:10.1155/2013/343560
• Thornalley, P. J., Battah, S., Ahmed, N., Karachalias, N., Agalou, S., Babaei-Jadidi, R., & Dawnay, A. (2003). Quantitative screening of advanced glycation endproducts in cellular and extracellular proteins by tandem mass spectrometry. Biochemical Journal, 375(3), 581-592.
• Umpierre, D., Ribeiro, P. A., Kramer, C. K., Leitao, C. B., Zucatti, A. T., Azevedo, M. J., . . . Schaan, B. D. (2011). Physical activity advice only or structured exercise training and association with HbA1c levels in type 2 diabetes: a systematic review and meta-analysis. Jama, 305(17), 1790-1799.
• Uribarri, J., Woodruff, S., Goodman, S., Cai, W., Chen, X., Pyzik, R., . . . Vlassara, H. (2010). Advanced glycation end products in foods and a practical guide to their reduction in the diet. Journal of the American Dietetic Association, 110(6), 911-916. e912.
• Varma, R., Bressler, N. M., Doan, Q. V., Gleeson, M., Danese, M., Bower, J. K., . . . Colman, S. (2014). Prevalence of and risk factors for diabetic macular edema in the United States. JAMA ophthalmology, 132(11), 1334-1340.
• Walker, J., Cove, D., Beevers, D., Dodson, P., Leatherdale, B., Fletcher, R., & Wright, A. (1985). Cigarette smoking, blood pressure and the control of blood glucose in the development of diabetic retinopathy. Diabetes Research (Edinburgh, Scotland), 2(4), 183-186.
• Wass, J. A., & Stewart, P. M. (2011). Oxford textbook of endocrinology and diabetes: Oxford University Press.
• World Health Organization. (2016). Global report on diabetes: executive summary (No. WHO/NMH/NVI/16.3). World Health Organization.
• Paetkau, M. E., Boyd, T., Winship, B., & Grace, M. (1977). Cigarette smoking and diabetic retinopathy. Diabetes, 26(1), 46-49.
• Wolever, T., Vorster, H., Björck, I., Brand-Miller, J., Brighenti, F., Mann, J., . . . Perry, T. (2003). Determination of the glycaemic index of foods: interlaboratory study. European Journal of Clinical Nutrition, 57(3), 475-482.
• Wolever, T. M., Brand-Miller, J. C., Abernethy, J., Astrup, A., Atkinson, F., Axelsen, M., . . . Brynes, A. (2008). Measuring the glycemic index of foods: interlaboratory study. The American journal of clinical nutrition, 87(1), 247S-257S.
• Yamaguchi, M., Nakamura, N., Nakano, K., Kitagawa, Y., Shigeta, H., Hasegawa, G., . . . Fukui, I. (1998). Immunochemical quantification of crossline as a fluorescent advanced glycation endproduct in erythrocyte membrane proteins from diabetic patients with or without retinopathy. Diabetic Medicine, 15(6), 458-462.
• Yau, J. W., Rogers, S. L., Kawasaki, R., Lamoureux, E. L., Kowalski, J. W., Bek, T., . . . Grauslund, J. (2012). Global prevalence and major risk factors of diabetic retinopathy. Diabetes care, 35(3), 556-564.
• Yokoi, M., Yamagishi, S., Takeuchi, M., Ohgami, K., Okamoto, T., Saito, W., . . . Ohno, S. (2005). Elevations of AGE and vascular endothelial growth factor with decreased total antioxidant status in the vitreous fluid of diabetic patients with retinopathy. British Journal of Ophthalmology, 89(6), 673-675.
• Zapata, M. A., Badal, J., Fonollosa, A., Boixadera, A., & García-Arumí, J. (2010). Insulin resistance and diabetic macular oedema in type 2 diabetes mellitus. British Journal of Ophthalmology, 94(9), 1230-1232.