Does blood type have an effect on the course of COVID-19?

Year 2022, Volume: 7 Issue: Covid-19 Ek Sayısı, 100 - 107, 23.06.2022

Fatma Yılmaz , Murat Albayrak , Abdulkerim Yıldız , Hacer Berna Afacan Öztürk , Senem Maral , Pınar Akyol Merih Reis Aras , Buğra Sağlam , Mesut Tığlıoğlu

https://doi.org/10.25279/sak.1014330

Abstract

Introduction
Predictive parameters that can affect the course of this infection have been the main topic of research since the beginning of the COVID-19 (Coronavirus disease 2019) pandemic. Since the discovery of blood groups, the effect of these on infectious diseases has always been of interest.
Objectives
To analyze the effect of ABO blood group on mortality, hospitalization duration and hematological and cytokine storm parameters in patients with COVID-19.
Patients and methods: This retrospective study was conducted on 140 patients diagnosed with COVID-19. Demographic characteristics, laboratory parameters including ABO blood group, complete blood count (CBC) parameters, biochemical tests, cytokine storm parameters, duration of hospitalization, and final status (discharge or death) were recorded.
Results: The 140 patients included in the analysis comprised 72 (51.4%) males and 68 (48.6%) females with a mean age of 66.3±14.0 years. . Age and gender, hospitalization duration and mortality rates were similar in all blood group types. Only D-dimer levels were found to be higher in blood group A compared with other blood groups.
Conclusion: Although no difference in mortality was determined between groups, the D-dimer level was statistically significantly higher in COVID-19 patients with A blood group. Larger studies are needed to reflect D-dimer levels on the clinical course of infection, and thus on daily practice.

Keywords

Mortality, ABO Blood Group System, SARS-CoV-2, Fibrin fragmant D

Kan grubunun COVID-19’un seyrine etkisi var mı?

Abstract

Giriş
Bu enfeksiyonun seyrini etkileyebilecek öngörücü parametreler, COVID-19 (Koronavirüs hastalığı 2019) pandemisinin başlangıcından bu yana ana araştırma konusu olmuştur. Kan gruplarının keşfinden bu yana bunların bulaşıcı hastalıklar üzerindeki etkisi her zaman ilgi çekici olmuştur.
Araç ve yöntemler
COVID-19 hastalarında ABO kan grubunun mortalite, hastanede kalış süresi ve hematolojik ve sitokin fırtınası parametreleri üzerindeki etkisini analiz etmek.
Bu retrospektif çalışma, COVID-19 tanısı konan 140 hasta üzerinde yapıldı. Demografik özellikler, ABO kan grubunu içeren laboratuvar parametreleri, tam kan sayımı (CBC) parametreleri, biyokimyasal testler, sitokin fırtınası parametreleri, hastanede kalış süresi ve son durum (taburculuk veya ölüm) kaydedildi.
Bulgular: Analize dahil edilen 140 hastanın 72’si (%51.4) erkek ve 68’i (%48.6) kadından oluşmakta olup, ortalama yaşları 66.3±14.0 yıldır. Yaş ve cinsiyet, hastanede kalış süresi ve ölüm oranları tüm kan grubu gruplarında benzerdi. Sadece D-dimer değerleri A kan grubunda diğer kan gruplarına göre daha yüksek bulundu.
Tartışma: Gruplar arasında mortalite açısından fark saptanmamakla birlikte A kan grubuna sahip COVID-19 hastalarında D-dimer düzeyi istatistiksel olarak anlamlı derecede yüksekti. D-dimer düzeylerini enfeksiyonun klinik seyrine ve dolayısıyla günlük uygulamaya yansıtmak için daha büyük çalışmalara ihtiyaç vardır.

Keywords

ABO Kan Grubu Sistemi, SARS-CoV-2, Fibrin Fragman D, Ölüm Oranı

References

• 1. Aslaner, H., Gökçek, M. B., Benli, A. R., Baydemir, R., GÜVEN, Z., AKYOL, G., & Kaynar, L. The Effect of Blood Groups on Infection and Prognosis of SARS-CoV-2. Medical Records, 3(3), 191-196.
• 2. Batool, Z., Durrani, S. H., & Tariq, S. (2017). Association of ABO and Rh blood group types to hepatitis B, hepatitis C, HIV and Syphillis infection, a five year’experience in healthy blood donors in a tertiary care hospital. Journal of Ayub Medical College Abbottabad, 29(1), 90-92.
• 3. Cheng, Y., Cheng, G., Chui, C., Lau, F., Chan, P. K., Ng, M. H., . . . Wong, R. S. (2005). ABO blood group and susceptibility to severe acute respiratory syndrome. Jama, 293(12), 1447-1451.
• 4. Dilek, İ., Öner, A. F., Mete, R., Erkoç, R., Türkdoğan, K., Topal, C., . . . Aksoy, H. (1998). Van İlindeki Kan Grupları Dağılımının Türkiye ve Diğer Bazı Ülkelerle Karşılaştırılması. Van Tıp Dergisi, 5(4), 236-238.
• 5. Fauci, A. S., Lane, H. C., & Redfield, R. R. (2020). Covid-19—navigating the uncharted. 6. Fogarty, H., Townsend, L., Ni Cheallaigh, C., Bergin, C., Martin‐Loeches, I., Browne, P., . . . Byrne, M. (2020). COVID19 coagulopathy in Caucasian patients. British journal of haematology, 189(6), 1044-1049.
• 7. Gemmati, D., Bramanti, B., Serino, M. L., Secchiero, P., Zauli, G., & Tisato, V. (2020). COVID-19 and individual genetic susceptibility/receptivity: role of ACE1/ACE2 genes, immunity, inflammation and coagulation. might the double X-chromosome in females be protective against SARS-CoV-2 compared to the single X-chromosome in males? International journal of molecular sciences, 21(10), 3474.
• 8. Göker, H., Karakulak, E. A., Demiroğlu, H., Ceylan, Ç. M. A., Büyükaşik, Y., Inkaya, A. Ç., . . . Uzun, Ö. (2020). The effects of blood group types on the risk of COVID-19 infection and its clinical outcome. Turkish journal of medical sciences, 50(4), 679-683.
• 9. Jing, W., Zhao, S., Liu, J., & Liu, M. (2020). ABO blood groups and hepatitis B virus infection: a systematic review and meta-analysis. BMJ open, 10(1).
• 10. Li, J., Wang, X., Chen, J., Cai, Y., Deng, A., & Yang, M. (2020). Association between ABO blood groups and risk of SARS‐CoV‐2 pneumonia. British journal of haematology, 190(1), 24-27.
• 11. Li, W., Wong, S.-K., Li, F., Kuhn, J. H., Huang, I.-C., Choe, H., & Farzan, M. (2006). Animal origins of the severe acute respiratory syndrome coronavirus: insight from ACE2-S-protein interactions. Journal of virology, 80(9), 4211-4219.
• 12. Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Zhu, N. (2020). Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. The lancet, 395(10224), 565-574.
• 13. Luo, Y., Yuan, X., Xue, Y., Mao, L., Lin, Q., Tang, G., . . . Wang, F. (2020). Using a diagnostic model based on routine laboratory tests to distinguish patients infected with SARS-CoV-2 from those infected with influenza virus. International Journal of Infectious Diseases, 95, 436-440.
• 14. Reid, M. E., Lomas-Francis, C., & Olsson, M. L. (2012). The blood group antigen factsbook: Academic press.
• 15. Tang, N., Li, D., Wang, X., & Sun, Z. (2020). Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. Journal of thrombosis and haemostasis, 18(4), 844-847.
• 16. Yamamoto, F. (2004). ABO blood group system--ABH oligosaccharide antigens, anti-A and anti-B, A and B glycosyltransferases, and ABO genes. Immunohematology, 20(1), 3-22.
• 17. Yin, S., Huang, M., Li, D., & Tang, N. (2021). Difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2. Journal of thrombosis and thrombolysis, 51(4), 1107-1110.
• 18. Zhao, J., Yang, Y., Huang, H., Li, D., Gu, D., Lu, X., . . . Liu, Y. (2020). Relationship between the ABO Blood Group and the COVID-19 Susceptibility. Clinical Infectious Diseases.
• 19. Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., . . . Gu, X. (2020). Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The lancet, 395(10229), 1054-1062.
• 20. Zietz, M., & Tatonetti, N. P. (2020). Testing the association between blood type and COVID-19 infection, intubation, and death. MedRxiv.