Metal-containing Coordination Complexes (MCCs): Assessment of Biological Activity with Helicobacter pylori Caused Gastric Ulcer

Year 2022, , 768 - 775, 31.08.2022

Dursun Kısa , Yusuf Ceylan , Merve Yıldırım Sümeyra Durgun , Nesrin Korkmaz

https://doi.org/10.16984/saufenbilder.1068212

Abstract

The ulcer is a vital disease that unfavorably affects human health globally. Helicobacter pylori, a reason forhave an antibacterial effect against ulcers and some stomach disorders, live on using the urease enzyme and induces the condition to occur. Metal coordination complexes (MCC) are used in numerous industrial areas and the health field. Cyanide bridged metal complexes are also applied in several places. In the current study, antibacterial characteristic of (C1), [Ni(bishydeten)2Ag(CN)2][Ag(CN)2].H2O), and (C2), ([Ni(hydeten)2Ag(CN)2][Ag(CN)2], MCC were analyzed by disk diffusion and broth dilution broth and urease enzyme inhibition assays were performed. As a result of both antibacterial tests, C1 and C2 were observed to provide favorable effects. The synthesized compounds have effective inhibitory potential with IC50 value between 26.65±1.21 and 12.37±0.87 µM for urease.

Keywords

Metal coordination complexes, Helicobacter pylori, antibacterial, enzyme activity, urease

Supporting Institution

TÜBİTAK

Project Number

1919B011902147

Thanks

We would like to thank TÜBİTAK for supporting this project.

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