Research Article
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Year 2022, , 1010 - 1021, 20.10.2022
https://doi.org/10.16984/saufenbilder.1109011

Abstract

References

  • [1] A.S. El-Tabl, F. A. El-Saied, W. Plass, A. N. Al- Hakimi, “Synthesis, spectroscopic characterization and biological activity of the metal complexes of the Schiff base derived from phenylaminoacetohydrazide and dibenzoylmethane,” Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 71, no. 1, pp. 90-99, 2008.
  • [2] Y. Li, Z. Y. Yang, M. F. Wang, “Synthesis, characterization, DNA binding properties, fluorescence studies and antioxidant activity of transition metal complexes with hesperetin-2-hydroxy benzoyl hydrazone,” Journal of Fluorescence, vol. 20, no. 4, pp. 891-905, 2010.
  • [3] M. A. El‐Bindary, A. A. El‐Bindary, “Synthesis, characterization, DNA binding, and biological action of dimedone arylhydrazone chelates,” Applied Organometallic Chemistry, vol. 36(4), pp. e6576, 2022.
  • [4] M. C. Rodrı̀guez-Arguelles, M. B. Ferrari, F. Bisceglie, C. Plizzi, G. Pelosi, S. Pinelli, M. Sassi, “Synthesis, characterization and biological activity of Ni, Cu and Zn complexes of isatin hydrazones,” Journal of Inorganic Biochemistry, vol. 98, no. 2, pp. 313-320, 2004.
  • [5] P. Yogeeswari, N. Menon, A. Semwal, M. Arjun, D. Sriram, “Discovery of molecules for the treatment of neuropathic pain: synthesis, antiallodynic and antihyperalgesic activities of 5-(4-nitrophenyl)furoic-2-acid hydrazones,” European Journal of Medicinal Chemistry., vol. 46, no. 7, pp. 2964-2971, 2011.
  • [6] M. S. S. Adam, O. M. El-Hady, M. M. Makhlouf, A. Bayazeed, N. M. El-Metwaly, A. D. M. Mohamad, “Effect of oxy-vanadium (IV) and oxy-zirconium (IV) ions in O, N-bidentate arylhydrazone complexes on their catalytic and biological potentials that supported via computerized usages,” Journal Of The Taiwan Institute Of Chemical Engineers., vol. 132, pp. 104168, 2022.
  • [7] M. C. Rodruguez-Arguelles, S. M. Vazques, P. T. Touceda, J. S. Matalobos, A. M .G. Deibe, M. B. Ferrari, G. Pelosi, C. Pelizzi, F. Zanil, “Complexes of 2-thio phene carbonyl and isonicotinoyl hydrazones of 3-(N-methyl)isatin. A study of their antimicrobial activity,” Journal of Inorganic Biochemistry, vol. 101, no. 1, pp. 138-147, 2007.
  • [8] C. Gokce, R. Gup, “Copper(II) complexes of acylhydrazones: synthesis, characterization and DNA interaction,” Applied Organometallic Chemistry, vol. 27, no. 5, pp. 263-268, 2013.
  • [9] C. Gokce, R. Gup, “Synthesis, characterization and DNA interaction of new copper(II) complexes of Schiff base-Arylhydrazones bearing naphthalene ring,” Journal of Photochemistry and Photobioloy B: Biology, vol. 122, pp. 15-23, 2013.
  • [10] J. R. Merchant, D. S. Clothia, “Antituberculous Schiff bases” Journal of Medicinal Chemistry, vol. 13, no. 2, pp. 335-336, 1970.
  • [11] J. O. Adeyemi, D. C. Onwudiwe, “The mechanisms of action involving dithiocarbamate complexes in biological systems,” Inorganica Chimica Acta, vol. 511, pp. 119809, 2020.
  • [12] K. Kiranmai, Y. Prashanthi, N .J. P. Subhashini, “Synthesis, characterization and biological activity of metal complexes of 3-amino-5-methyl isoxazole Schiff bases,” Journal of Chemical and Pharmaceutical Research, vol. 2, no.1, pp. 375-384, 2010.
  • [13] I. Kostova, L. Saso, “Advances in research of Schiff-base metal complexes as potent antioxidants,” Current Medicinal Chemistry, vol. 20(36), pp. 4609-4632, 2013.
  • [14] R. K. Crouch, T. W. Kensler, L. W. Oberley, J.R.J. Sorenson, “Possible medicinal uses of copper complexes. In: Biological and Inorganic Copper Chemistry,” Guilderland, New York, Adenine Press, 1986.
  • [15] J. R. Sorenson, “Bis(3,5-diisopropylsalicylato)copper(II), a potent radioprotectant with superoxide dismutase mimetic activity,” Journal of Medicinal Chemistry, vol. 27, no. 12, pp. 1747-1749,1984.
  • [16] X. B. Yang, J. Feng, J. Zhang, Z. W. Zhang, H. H. Lin, L .H. Zhou, X. Q. Yu, ”Synthesis, DNA binding and cleavage activities of the copper (II) complexes of estrogen-macrocyclic polyamine conjugates.,” Bioorganic & Medicinal Chemistry, vol. 16, no.7, pp. 3871-3877,2008.
  • [17] S. Apelgot, J. Coppey, A. Fromentin, E. Guille, M.F. Poupon, A. Roussel , “Altered distribution of copper (64Cu) in tumor-bearing mice and rats,” Anticancer Research, vol. 6, no. 2, pp. 159-164,1986.
  • [18] P. P. Silva, W. Guerra, J. N. Silveira, A. M. C. Ferreira, T. Bortolotto, F. L. Fischer, H. Terenzi, A. Neves and E. C. Pereira-Maia, “Two new ternary complexes of copper(II) with tetracycline or doxycycline and 1,10-phenanthroline and their potential as antitumoral: cytotoxicity and DNA cleavage,” Inorganic Chemistry., vol. 50, no.14, pp. 6414-6424, 2011.
  • [19] B. C. Bales, T. Kodama, Y. N. Weledji, M. Pitic, B. Mcunier, M. M. Greenberg, “Mechanistic studies on DNA damage by minor groove binding copper–phenanthroline conjugates,” Nucleic Acids Research, vol. 33, no.16, pp. 5371-5379, 2005.
  • [20] N. Dilek, B. Güneş, R. Gup, “4-Butoxy-N’-[1-(4-methylphenyl)ethyl-idene]benzohydrazide,” Acta Crystallographica Section E, vol. 68, no.9, pp.2763-2763, 2012.
  • [21] R. Gup, B. Kırkan, “Synthesis and spectroscopic studies of mixed-ligand and polymeric dinuclear transition metal complexes with bis-acylhydrazone tetradentate ligands and 1,10-phenanthroline,” Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol, 64, no. 3, pp. 809-815, 2006.
  • [22] A. A. R. U. Despaigne, J. G. Da Silva, A. C. M. Do Carmo, O. E. Piro, E. E. Castellano, H. Beraldo, “Copper(II) and zinc(II) complexes with 2-benzoylpyridine–methyl hydrazone,” Journal of Molecular Structure, vol. 920, no,1-3, pp. 97-102, 2009.
  • [23] A. P. Rebolledo, G. De Lima, L. N. Gambi, N. I. Speziali, D. F. Maia, C. B. Pinheiro, J. D. Ardisson, M. E. Cortes, H. Beraldo, “Tin(IV) complexes of 2-benzoylpyridine N(4)-phenylthiosemicarbazone: spectral characterization, structural studies and antifungal activity,” Applied Organometallic Chemistry, vol. 17, no.12,pp. 945-951,2003.
  • [24] S. Kulaksızoglu, C. Gokce, R. Gup,” Synthesis and characterization of bis(azine) ligands and metal complexes: DNA-interaction and extraction properties for metals and dichromate anions,” Turkish Journal of Chemistry, vol. 36, no.5, pp. 717-733, 2012.
  • [25] S. Naskar, S. Biswas, D. Mishra, B. Adhikary, L. R. Falvello, T. Soler, C. H. Schwalbe, S. K. Chattopadhyay, “Studies on the relative stabilities of Mn(II) and Mn(III) in complexes with N4O2 donor environments: crystal structures of [Mn(pybzhz)2] and [Mn(Ophsal)(imzH)2]ClO4 (pybzhz=N-(benzoyl)-N′-(picolinylidene) hydrazine, Ophsal= N, N′-o-phenylenebis(salicylideneimine), imzH= imidazole),” Inorganica Chimica Acta, vol. 357, no.14,pp. 4257-4264, 2004.
  • [26] R. Dinda, P. Sengupta, S. Ghash, T. C. M. Mak, “Valence delocalization in a mixed-oxidation divanadium(IV, V) complex electrogenerated from its structurally characterized divanadium(V) analogue with a tridentate (ONO) ligand,” Inorganic Chemistry, vol. 41, no. 6, pp. 1684-1688, 2002.
  • [27] A. Sreekanth, C. R. Nayar, M. R. P. Kurup, “Cobalt(III) complexes of 2-hydroxyacetophenone N(4) phenyl semicarbazone containing heterocyclic coligands: syntheses, structure, and spectral studies,” Polyhedron, vol. 23, no.1, pp. 41-47, 2004.
  • [28] R. Dinda, P. Sengupta, S. Ghash, W. S. Sheldrick, “Synthesis, structure, and reactivity of a new mononuclear molybdenum (VI) complex resembling the active center of molybdenum oxotransferases,” European Journal of Inorganic Chemistry, vol. 2003, no. 2, pp. 363-369, 2003.
  • [29] R. Gup, “A new unsymmetrical vic-dioxime bearing salicylaldehyde 4-aminobenzoylhydrazone and its homo-and heterotrinuclear complexes with copper (II) and nickel (II) ions,” Russian Journal of Coordination Chemistry, vol. 32, no. 2, pp. 99-108, 2006.
  • [30] L .L. Koh, O. L. Kon, Y. C. Loh, R. C. Ranford, A. L. C. Tan, Y. Y. Tjan, “Complexes of salicylaldehyde acylhydrazones: cytotoxicity, QSAR and crystal structure of the sterically hindered t-butyl dimer,” Journal of Inorganic Biochemistry, vol. 72, no. 3-4, pp. 155-162,1998.
  • [31] R. Gup, E. Giziroğlu, “Metal complexes and solvent extraction properties of isonitrosoacetophenone 2-aminobenzoylhydrazone,” Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 65, no. (3-4), pp. 719-726, 2006.
  • [32] O. Usluer, R. Gup, “Synthesis and characterization of copper(ii) complexes containing isonitrosoacetophenone 4-aminobenzoylhydrazone,” Polish Journal of Chemistry, vol. 81, no. 7, pp. 1257-1265, 2007.
  • [33] F. Karipcin, B. Dede, S. Percin-Ozkorucuklu, E. Kabalcilar, “Mn(II), Co(II) and Ni(II) complexes of 4-(2-thiazolylazo)resorcinol: synthesis, characterization, catalase-like activity, thermal and electrochemical behavior,” Dyes and Pigments, vol. 84, no. 1, pp.14-18, 2010.
  • [34] S. Gama, F. Mendes, F. Marques, “Copper(II) complexes with tridentate pyrazole-based ligands: synthesis, characterization, DNA cleavage activity and cytotoxicity,” Journal of Inorganic Biochemistry, vol. 105, no. 5, pp. 637-644, 2011.
  • [35] D. Lahiri, S. Roy, S. Saha, R. Majumdar, R. R. Dighe, A. R. Chakravarty, “Anaerobic DNA cleavage activity in red light and photocytotoxicity of (pyridine-2-thiol) cobalt (III) complexes of phenanthroline bases,” Dalton Transactions, vol.39, no.7, pp.1807-1816, 2010.
  • [36] B. Dede, I. Özmen, F. Karipcin, M. Cengiz, “Homo- and heteropolynuclear copper(II) complexes containing a new diimine–dioxime ligand and 1,10-phenanthroline: synthesis, characterization, solvent-extraction studies, catalase-like functions and DNA cleavage abilities,” Applied Organometalic. Chemistry, vol. 23, no. 12, pp. 512-519, 2009.
  • [37] P. U. Maheswari, S. Barend, S. Özalp-Yaman, P. De Hoog, H. Casellas, A. J. Teat, C. Massera, M. Lutz, A. L. Spek, J. P. Van Wezel, P. Gamez, J. Reedijk, “Unique ligand based oxidative cleavage by zinc(II) complexes of hpyramol and hpyrimol” European Journal of Chemistry, vol. 13, no.18, pp. 5213-5222, 2007.
  • [38] X. Dong, X. Wan, M. Lin, H. Sun, X. Yang, Z. Guo, “Promotive effect of the platinum moiety on the DNA cleavage activity of copper-based artificial nucleases,” Inorganic Chemistry, vol. 49, no.5, pp. 2541-2549, 2010.
  • [39] L. Z. Li, C. Zhao, T. Xu, H. Wei Ji, Y. Hong Yu, G. Qiang Guo, H. Chao, “Synthesis, crystal structure and nuclease activity of a Schiff base copper(II) complex,” Journal of Inorganic Biochemistry, vol. 9 no.5, pp.1076-1082, 2005.
  • [40] E. Lamour, S. Routier, J. L. Bernier, J. P. Catteau, C. Bailly, H. Vezin, “Oxidation of Cu-II to Cu-III, free radical production, and DNA cleavage by hydroxy-salen-copper complexes. Isomeric effects studied by ESR and electrochemistry,” Journal of the American Chemical Society, 121(9), 1862-1869, 1999.
  • [41] C. Gökçe, R. Gup, “Synthesis, characterization and DNA interaction of the transition metal complexes with 2-formyl furan-derived aroylhydrazones,” Main Group Chemistry, vol. 12, no.1, pp. 25-38, 2013.

Copper(II) Complexes of a New Hydrazones with Aliphatic Groups: Synthesis, Characterisation and Nuclease Activity

Year 2022, , 1010 - 1021, 20.10.2022
https://doi.org/10.16984/saufenbilder.1109011

Abstract

Two new copper(II) complexes of bidentate arylhydrazone ligands have prepared and studied. Elemental analysis, SEM-EDS, thermal gravimetric analysis (TGA), powder X-ray diffraction (XRD), and a number of spectroscopic techniques were used to determine the structures of the compounds (FTIR, UV-Vis, 1H and 13C-NMR). Using agarose gel electrophoresis, the DNA cleavage activities of the produced copper complexes were investigated in the absence and presence of hydrogen peroxide. It was also investigated the influence of compound dose on the DNA cleavage process. The results show that in the presence of an oxidant agent, all of the complexes break pBR322 DNA. At the concentration of 10 µM, [Cu(L1)2] converted the supercoil DNA into two forms, while [Cu(L1)2] formed only the nicked form. The mechanistic analyses show that the active oxidative species for DNA breakage is a species generated by hydrogen peroxide and the copper(II) metal. The compounds also cleaveged pBR322 DNA in the absence of H2O2, marginally.

References

  • [1] A.S. El-Tabl, F. A. El-Saied, W. Plass, A. N. Al- Hakimi, “Synthesis, spectroscopic characterization and biological activity of the metal complexes of the Schiff base derived from phenylaminoacetohydrazide and dibenzoylmethane,” Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 71, no. 1, pp. 90-99, 2008.
  • [2] Y. Li, Z. Y. Yang, M. F. Wang, “Synthesis, characterization, DNA binding properties, fluorescence studies and antioxidant activity of transition metal complexes with hesperetin-2-hydroxy benzoyl hydrazone,” Journal of Fluorescence, vol. 20, no. 4, pp. 891-905, 2010.
  • [3] M. A. El‐Bindary, A. A. El‐Bindary, “Synthesis, characterization, DNA binding, and biological action of dimedone arylhydrazone chelates,” Applied Organometallic Chemistry, vol. 36(4), pp. e6576, 2022.
  • [4] M. C. Rodrı̀guez-Arguelles, M. B. Ferrari, F. Bisceglie, C. Plizzi, G. Pelosi, S. Pinelli, M. Sassi, “Synthesis, characterization and biological activity of Ni, Cu and Zn complexes of isatin hydrazones,” Journal of Inorganic Biochemistry, vol. 98, no. 2, pp. 313-320, 2004.
  • [5] P. Yogeeswari, N. Menon, A. Semwal, M. Arjun, D. Sriram, “Discovery of molecules for the treatment of neuropathic pain: synthesis, antiallodynic and antihyperalgesic activities of 5-(4-nitrophenyl)furoic-2-acid hydrazones,” European Journal of Medicinal Chemistry., vol. 46, no. 7, pp. 2964-2971, 2011.
  • [6] M. S. S. Adam, O. M. El-Hady, M. M. Makhlouf, A. Bayazeed, N. M. El-Metwaly, A. D. M. Mohamad, “Effect of oxy-vanadium (IV) and oxy-zirconium (IV) ions in O, N-bidentate arylhydrazone complexes on their catalytic and biological potentials that supported via computerized usages,” Journal Of The Taiwan Institute Of Chemical Engineers., vol. 132, pp. 104168, 2022.
  • [7] M. C. Rodruguez-Arguelles, S. M. Vazques, P. T. Touceda, J. S. Matalobos, A. M .G. Deibe, M. B. Ferrari, G. Pelosi, C. Pelizzi, F. Zanil, “Complexes of 2-thio phene carbonyl and isonicotinoyl hydrazones of 3-(N-methyl)isatin. A study of their antimicrobial activity,” Journal of Inorganic Biochemistry, vol. 101, no. 1, pp. 138-147, 2007.
  • [8] C. Gokce, R. Gup, “Copper(II) complexes of acylhydrazones: synthesis, characterization and DNA interaction,” Applied Organometallic Chemistry, vol. 27, no. 5, pp. 263-268, 2013.
  • [9] C. Gokce, R. Gup, “Synthesis, characterization and DNA interaction of new copper(II) complexes of Schiff base-Arylhydrazones bearing naphthalene ring,” Journal of Photochemistry and Photobioloy B: Biology, vol. 122, pp. 15-23, 2013.
  • [10] J. R. Merchant, D. S. Clothia, “Antituberculous Schiff bases” Journal of Medicinal Chemistry, vol. 13, no. 2, pp. 335-336, 1970.
  • [11] J. O. Adeyemi, D. C. Onwudiwe, “The mechanisms of action involving dithiocarbamate complexes in biological systems,” Inorganica Chimica Acta, vol. 511, pp. 119809, 2020.
  • [12] K. Kiranmai, Y. Prashanthi, N .J. P. Subhashini, “Synthesis, characterization and biological activity of metal complexes of 3-amino-5-methyl isoxazole Schiff bases,” Journal of Chemical and Pharmaceutical Research, vol. 2, no.1, pp. 375-384, 2010.
  • [13] I. Kostova, L. Saso, “Advances in research of Schiff-base metal complexes as potent antioxidants,” Current Medicinal Chemistry, vol. 20(36), pp. 4609-4632, 2013.
  • [14] R. K. Crouch, T. W. Kensler, L. W. Oberley, J.R.J. Sorenson, “Possible medicinal uses of copper complexes. In: Biological and Inorganic Copper Chemistry,” Guilderland, New York, Adenine Press, 1986.
  • [15] J. R. Sorenson, “Bis(3,5-diisopropylsalicylato)copper(II), a potent radioprotectant with superoxide dismutase mimetic activity,” Journal of Medicinal Chemistry, vol. 27, no. 12, pp. 1747-1749,1984.
  • [16] X. B. Yang, J. Feng, J. Zhang, Z. W. Zhang, H. H. Lin, L .H. Zhou, X. Q. Yu, ”Synthesis, DNA binding and cleavage activities of the copper (II) complexes of estrogen-macrocyclic polyamine conjugates.,” Bioorganic & Medicinal Chemistry, vol. 16, no.7, pp. 3871-3877,2008.
  • [17] S. Apelgot, J. Coppey, A. Fromentin, E. Guille, M.F. Poupon, A. Roussel , “Altered distribution of copper (64Cu) in tumor-bearing mice and rats,” Anticancer Research, vol. 6, no. 2, pp. 159-164,1986.
  • [18] P. P. Silva, W. Guerra, J. N. Silveira, A. M. C. Ferreira, T. Bortolotto, F. L. Fischer, H. Terenzi, A. Neves and E. C. Pereira-Maia, “Two new ternary complexes of copper(II) with tetracycline or doxycycline and 1,10-phenanthroline and their potential as antitumoral: cytotoxicity and DNA cleavage,” Inorganic Chemistry., vol. 50, no.14, pp. 6414-6424, 2011.
  • [19] B. C. Bales, T. Kodama, Y. N. Weledji, M. Pitic, B. Mcunier, M. M. Greenberg, “Mechanistic studies on DNA damage by minor groove binding copper–phenanthroline conjugates,” Nucleic Acids Research, vol. 33, no.16, pp. 5371-5379, 2005.
  • [20] N. Dilek, B. Güneş, R. Gup, “4-Butoxy-N’-[1-(4-methylphenyl)ethyl-idene]benzohydrazide,” Acta Crystallographica Section E, vol. 68, no.9, pp.2763-2763, 2012.
  • [21] R. Gup, B. Kırkan, “Synthesis and spectroscopic studies of mixed-ligand and polymeric dinuclear transition metal complexes with bis-acylhydrazone tetradentate ligands and 1,10-phenanthroline,” Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol, 64, no. 3, pp. 809-815, 2006.
  • [22] A. A. R. U. Despaigne, J. G. Da Silva, A. C. M. Do Carmo, O. E. Piro, E. E. Castellano, H. Beraldo, “Copper(II) and zinc(II) complexes with 2-benzoylpyridine–methyl hydrazone,” Journal of Molecular Structure, vol. 920, no,1-3, pp. 97-102, 2009.
  • [23] A. P. Rebolledo, G. De Lima, L. N. Gambi, N. I. Speziali, D. F. Maia, C. B. Pinheiro, J. D. Ardisson, M. E. Cortes, H. Beraldo, “Tin(IV) complexes of 2-benzoylpyridine N(4)-phenylthiosemicarbazone: spectral characterization, structural studies and antifungal activity,” Applied Organometallic Chemistry, vol. 17, no.12,pp. 945-951,2003.
  • [24] S. Kulaksızoglu, C. Gokce, R. Gup,” Synthesis and characterization of bis(azine) ligands and metal complexes: DNA-interaction and extraction properties for metals and dichromate anions,” Turkish Journal of Chemistry, vol. 36, no.5, pp. 717-733, 2012.
  • [25] S. Naskar, S. Biswas, D. Mishra, B. Adhikary, L. R. Falvello, T. Soler, C. H. Schwalbe, S. K. Chattopadhyay, “Studies on the relative stabilities of Mn(II) and Mn(III) in complexes with N4O2 donor environments: crystal structures of [Mn(pybzhz)2] and [Mn(Ophsal)(imzH)2]ClO4 (pybzhz=N-(benzoyl)-N′-(picolinylidene) hydrazine, Ophsal= N, N′-o-phenylenebis(salicylideneimine), imzH= imidazole),” Inorganica Chimica Acta, vol. 357, no.14,pp. 4257-4264, 2004.
  • [26] R. Dinda, P. Sengupta, S. Ghash, T. C. M. Mak, “Valence delocalization in a mixed-oxidation divanadium(IV, V) complex electrogenerated from its structurally characterized divanadium(V) analogue with a tridentate (ONO) ligand,” Inorganic Chemistry, vol. 41, no. 6, pp. 1684-1688, 2002.
  • [27] A. Sreekanth, C. R. Nayar, M. R. P. Kurup, “Cobalt(III) complexes of 2-hydroxyacetophenone N(4) phenyl semicarbazone containing heterocyclic coligands: syntheses, structure, and spectral studies,” Polyhedron, vol. 23, no.1, pp. 41-47, 2004.
  • [28] R. Dinda, P. Sengupta, S. Ghash, W. S. Sheldrick, “Synthesis, structure, and reactivity of a new mononuclear molybdenum (VI) complex resembling the active center of molybdenum oxotransferases,” European Journal of Inorganic Chemistry, vol. 2003, no. 2, pp. 363-369, 2003.
  • [29] R. Gup, “A new unsymmetrical vic-dioxime bearing salicylaldehyde 4-aminobenzoylhydrazone and its homo-and heterotrinuclear complexes with copper (II) and nickel (II) ions,” Russian Journal of Coordination Chemistry, vol. 32, no. 2, pp. 99-108, 2006.
  • [30] L .L. Koh, O. L. Kon, Y. C. Loh, R. C. Ranford, A. L. C. Tan, Y. Y. Tjan, “Complexes of salicylaldehyde acylhydrazones: cytotoxicity, QSAR and crystal structure of the sterically hindered t-butyl dimer,” Journal of Inorganic Biochemistry, vol. 72, no. 3-4, pp. 155-162,1998.
  • [31] R. Gup, E. Giziroğlu, “Metal complexes and solvent extraction properties of isonitrosoacetophenone 2-aminobenzoylhydrazone,” Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 65, no. (3-4), pp. 719-726, 2006.
  • [32] O. Usluer, R. Gup, “Synthesis and characterization of copper(ii) complexes containing isonitrosoacetophenone 4-aminobenzoylhydrazone,” Polish Journal of Chemistry, vol. 81, no. 7, pp. 1257-1265, 2007.
  • [33] F. Karipcin, B. Dede, S. Percin-Ozkorucuklu, E. Kabalcilar, “Mn(II), Co(II) and Ni(II) complexes of 4-(2-thiazolylazo)resorcinol: synthesis, characterization, catalase-like activity, thermal and electrochemical behavior,” Dyes and Pigments, vol. 84, no. 1, pp.14-18, 2010.
  • [34] S. Gama, F. Mendes, F. Marques, “Copper(II) complexes with tridentate pyrazole-based ligands: synthesis, characterization, DNA cleavage activity and cytotoxicity,” Journal of Inorganic Biochemistry, vol. 105, no. 5, pp. 637-644, 2011.
  • [35] D. Lahiri, S. Roy, S. Saha, R. Majumdar, R. R. Dighe, A. R. Chakravarty, “Anaerobic DNA cleavage activity in red light and photocytotoxicity of (pyridine-2-thiol) cobalt (III) complexes of phenanthroline bases,” Dalton Transactions, vol.39, no.7, pp.1807-1816, 2010.
  • [36] B. Dede, I. Özmen, F. Karipcin, M. Cengiz, “Homo- and heteropolynuclear copper(II) complexes containing a new diimine–dioxime ligand and 1,10-phenanthroline: synthesis, characterization, solvent-extraction studies, catalase-like functions and DNA cleavage abilities,” Applied Organometalic. Chemistry, vol. 23, no. 12, pp. 512-519, 2009.
  • [37] P. U. Maheswari, S. Barend, S. Özalp-Yaman, P. De Hoog, H. Casellas, A. J. Teat, C. Massera, M. Lutz, A. L. Spek, J. P. Van Wezel, P. Gamez, J. Reedijk, “Unique ligand based oxidative cleavage by zinc(II) complexes of hpyramol and hpyrimol” European Journal of Chemistry, vol. 13, no.18, pp. 5213-5222, 2007.
  • [38] X. Dong, X. Wan, M. Lin, H. Sun, X. Yang, Z. Guo, “Promotive effect of the platinum moiety on the DNA cleavage activity of copper-based artificial nucleases,” Inorganic Chemistry, vol. 49, no.5, pp. 2541-2549, 2010.
  • [39] L. Z. Li, C. Zhao, T. Xu, H. Wei Ji, Y. Hong Yu, G. Qiang Guo, H. Chao, “Synthesis, crystal structure and nuclease activity of a Schiff base copper(II) complex,” Journal of Inorganic Biochemistry, vol. 9 no.5, pp.1076-1082, 2005.
  • [40] E. Lamour, S. Routier, J. L. Bernier, J. P. Catteau, C. Bailly, H. Vezin, “Oxidation of Cu-II to Cu-III, free radical production, and DNA cleavage by hydroxy-salen-copper complexes. Isomeric effects studied by ESR and electrochemistry,” Journal of the American Chemical Society, 121(9), 1862-1869, 1999.
  • [41] C. Gökçe, R. Gup, “Synthesis, characterization and DNA interaction of the transition metal complexes with 2-formyl furan-derived aroylhydrazones,” Main Group Chemistry, vol. 12, no.1, pp. 25-38, 2013.
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Details

Primary Language English
Subjects Structural Biology, Chemical Engineering
Journal Section Research Articles
Authors

Cansu Topkaya 0000-0002-6834-4841

Publication Date October 20, 2022
Submission Date April 26, 2022
Acceptance Date September 2, 2022
Published in Issue Year 2022

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APA Topkaya, C. (2022). Copper(II) Complexes of a New Hydrazones with Aliphatic Groups: Synthesis, Characterisation and Nuclease Activity. Sakarya University Journal of Science, 26(5), 1010-1021. https://doi.org/10.16984/saufenbilder.1109011
AMA Topkaya C. Copper(II) Complexes of a New Hydrazones with Aliphatic Groups: Synthesis, Characterisation and Nuclease Activity. SAUJS. October 2022;26(5):1010-1021. doi:10.16984/saufenbilder.1109011
Chicago Topkaya, Cansu. “Copper(II) Complexes of a New Hydrazones With Aliphatic Groups: Synthesis, Characterisation and Nuclease Activity”. Sakarya University Journal of Science 26, no. 5 (October 2022): 1010-21. https://doi.org/10.16984/saufenbilder.1109011.
EndNote Topkaya C (October 1, 2022) Copper(II) Complexes of a New Hydrazones with Aliphatic Groups: Synthesis, Characterisation and Nuclease Activity. Sakarya University Journal of Science 26 5 1010–1021.
IEEE C. Topkaya, “Copper(II) Complexes of a New Hydrazones with Aliphatic Groups: Synthesis, Characterisation and Nuclease Activity”, SAUJS, vol. 26, no. 5, pp. 1010–1021, 2022, doi: 10.16984/saufenbilder.1109011.
ISNAD Topkaya, Cansu. “Copper(II) Complexes of a New Hydrazones With Aliphatic Groups: Synthesis, Characterisation and Nuclease Activity”. Sakarya University Journal of Science 26/5 (October 2022), 1010-1021. https://doi.org/10.16984/saufenbilder.1109011.
JAMA Topkaya C. Copper(II) Complexes of a New Hydrazones with Aliphatic Groups: Synthesis, Characterisation and Nuclease Activity. SAUJS. 2022;26:1010–1021.
MLA Topkaya, Cansu. “Copper(II) Complexes of a New Hydrazones With Aliphatic Groups: Synthesis, Characterisation and Nuclease Activity”. Sakarya University Journal of Science, vol. 26, no. 5, 2022, pp. 1010-21, doi:10.16984/saufenbilder.1109011.
Vancouver Topkaya C. Copper(II) Complexes of a New Hydrazones with Aliphatic Groups: Synthesis, Characterisation and Nuclease Activity. SAUJS. 2022;26(5):1010-21.

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