In this study, 14 novel eugenol derivatives with the carbamate moiety were synthesized and their inhibitory effects on
acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were evaluated. 4-allyl-2-methoxyphenyl-(3,4-
dicholorophenyl)carbamate (3f) was found to be the most potent AChE inhibitor with IC50 value of 71.6 µM, and 4-
allyl-2-methoxyphenyl(3-methoxyphenyl)carbamate (3a) exhibited the strongest inhibition against BuChE with IC50
value of 0.58 µM. Additionally, structure-activity relationship were also investigated.
Bu çalışmada, karbamat grubu içeren 14 yeni eugenol türevleri sentezlenmiş ve bunların asetilkolinesteraz (AChE) ve
bütirilkolinesteraz (BuChE) enzimleri üzerine inhibitör etkileri incelenmiştir. 4-allil-2-metoksifenil-(3,4-
diklorofenil)karbamat (3f) 71.6 µM’lık IC50 değeri ile en iyi AChE inhibitörü olarak belirlenmiştir. 4-allil-2-
metoksifenil(3-metoksifenil)karbamat (3a) 0.58 µM’lık IC50 değeri ile BuChE’ye karşı en güçlü inhibisyonu
sergilemiştir. Ayrıca sentezlenen bileşikler için yapı-aktivite ilişkileri de incelenmiştir.
Subjects | Food Engineering |
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Journal Section | Research Articles |
Authors | |
Publication Date | June 1, 2017 |
Submission Date | October 21, 2016 |
Acceptance Date | November 30, 2016 |
Published in Issue | Year 2017 |
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