Anti-kanser ilacı imatinib’in elektro-oksidasyon prosesi ile gideriminin yüzey yanıt metodu kullanılarak incelenmesi

Year 2018, , 728 - 734, 01.04.2018

Özge Türkay Sibel Barışçı Anatoli Dimoglo

https://doi.org/10.16984/saufenbilder.336449

Abstract

 

Atıksularında bulunan farmasötikler
sucul canlılar üzerinde oldukça toksik olmaları nedeniyle büyüyen bir endişe
haline gelmektedir. Atıksularda ve yüzeysel sularda farmasötiklerin
konsantrasyonları µg/L ve ng/L gibi çok düşük seviyelerde olmasına rağmen
bunların kronik etkileri nedeniyle ciddi ve acil bir araştırmaya gerek
duyulmaktadır. Bu çevre ve sağlık problemlerinine yol açan farmasötik mikrokirleticileri
atıksulardan gidermek için klasik arıtma yöntemleri yetersiz olması sebebiyle
ileri arıtma yöntemlerine ihtiyac duyulmaktadır. Özellikle elektrokimyasal
prosesler bu tür mikrokirleticileri arıtmak için oldukça başarılı yöntemler
olarak dikkat çekmektedir. Bu çalışmada, Imatinib (IMT) adlı etken maddenin
elektro-oksidasyon yöntemi ile arıtılması çalışılmıştır. Imatinib etken
maddesinin arıtılması için kimyasal-elektrokimyasal stabiliteye sahip Ti/RuO₂
elektrotu kullanılmıştır. Optimum çalışma şartlarının belirlenmesi amacıyla
yüzey yanıt metodu (YYM) kullanılarak proses optimizasyonu yapılmıştır. 

Keywords

Imatinib, yüzey yanıt, elektro-oksidasyon

Evaluation of anti-cancer drug ımatinib removal by electro-oxidation process using response surface method

Abstract

The pharmaceuticals which are found in the wastewater
treatment effluents of the companies that produce cancer drug have become a
serious fear for biotic living beings as they are toxic. Although the
concentration of pharmaceuticals in surface water and wastewater are in low
levels like µg/L and ng/L levels, because of their chronical effects they are
needed to be removed from water immediately. They are not amenable to
conventional biological treatment due to their toxicity even at low
concentrations. Therefore, powerful oxidation methods have to be researched to
remove them from waters, thus avoiding their potential adverse health effects
on humans and animals. Especially electrochemical processes to purify such
micro pollutants have attracted attention as very successful methods. In this
study, electro-oxidation of Imatinib (IMT) has been studied. Ti/RuO₂
electrode which has chemical and elevtrochenical stability has been used. In
order to determine their operation conditions, process optimization has been
done by using Response Surface Method (RSM). 

Keywords

Imatinib, response surface, electro-oxidation

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