Bu çalışmada,
iki yeni dikloro-(1-alkilimidazolin)-(p-simen)rutenyum(II),
3 ve dikloro-(1-alkilbenzimidazol)-(p-simen)rutenyum(II), 4 kompleksi sentezlendi ve yapıları spektroskopik
tekniklerle karakterize edildi. Bu yeni metal komplekslerin in vitro antioksidan aktiviteleri; 2,2-difenil-1-pikrilhidrazil
(DPPH), hidroksil (•OH) ve süperoksit (O2-.) radikallerini inhibe etme özellikleri ile araştırıldı. Ayrıca
her bir metal kompleksinin toplam antioksidan aktivitesi de saptandı. 3
Numaralı kompleksin DPPH, hidroksil ve süperoksit radikallerini süpürme aktivitelerinin
ve toplam antioksidan aktivitesinin 4 numaralı kompleksten daha etkili olduğu bulundu.
In this study, two novel dichloro-(1-alkylimidazoline)-(p-cymene)ruthenium(II), 3 and dichloro-(1-alkylbenzimidazole)-(p-cymene)ruthenium(II), 4 complexes have been synthesized and characterized
by spectroscopic
techniques. In vitro antioxidant
activities of new metal complexes have been investigated by inhibition properties
of 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl (•OH) and superoxide (O2-.) radicals.
Additionally, total antioxidant activity of each metal
complexes was also determined. It was found that total antioxidant activity and
DPPH, hydroxyl and superoxide radicals scavenging
activities of compound 3 are more
efficient than compound 4.
Primary Language | Turkish |
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Subjects | Structural Biology |
Journal Section | Research Articles |
Authors | |
Publication Date | December 1, 2017 |
Submission Date | September 14, 2017 |
Acceptance Date | December 1, 2017 |
Published in Issue | Year 2017 |
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