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The Protective Effect of Grape Seed and Skin Extract and Ulva rigida Against Oxidative Stress Induced by Cisplatin on The Testis of Rats

Year 2020, , 312 - 323, 01.04.2020
https://doi.org/10.16984/saufenbilder.638725

Abstract

Cisplatin, an anticancer drug used in chemotherapy, has made considerable progress recently; particularly in the treatment of testicular cancer. However, the side effects of this treatment, limit its use. Grape Seed and Skin Extract (GSSE) and Ulva rigida (U. rigida) marine seaweeds are giving compounds with high antioxidant capacity. This work aims to develop a model in vivo to evaluate the protective effect of extracts of GSSE or U. rigida against the oxidative stress induced by cisplatin. This stress occurring in healthy cells is one of the major causes of the adverse effects of chemotherapy. Healthy male rats received an intraperitoneal injection of cisplatin only or cisplatin and GSSE or U. rigida extract. At the end of the treatment, the rats were sacrificed and from the crushed testicles; the supernatant was recovered for biochemical assays. The data showed that the dose of cisplatin induces testicular toxicity, and a pro-oxidant state characterized by increased levels of malondialdehyde, carbonyl proteins, superoxide anion, calcium and iron. Besides, treatment with cisplatin increases the activity of superoxide dismutase and inhibits the activity of catalase. GSSE or U. rigida extract exerts a protective effect on the testes of cisplatin-treated rats, or they protect against the adverse effects of oxidative stress induced by cisplatin to restore levels near control. This study demonstrated that GSSE and U. rigida can protect against cisplatin-induced cytotoxicity.

Supporting Institution

Higher Institute of Medical Technologies, University of Tunis El Manar

References

  • Sonia Hamlaoui
  • Sana mezghani
Year 2020, , 312 - 323, 01.04.2020
https://doi.org/10.16984/saufenbilder.638725

Abstract

References

  • Sonia Hamlaoui
  • Sana mezghani
There are 2 citations in total.

Details

Primary Language English
Subjects Structural Biology
Journal Section Research Articles
Authors

Rihab Ksouri 0000-0002-6241-2989

Souha Rabah This is me 0000-0002-6241-2989

Sana Mezghani 0000-0002-6241-2989

Sonia Hamlaoui 0000-0002-6241-2989

Publication Date April 1, 2020
Submission Date October 27, 2019
Acceptance Date January 7, 2020
Published in Issue Year 2020

Cite

APA Ksouri, R., Rabah, S., Mezghani, S., Hamlaoui, S. (2020). The Protective Effect of Grape Seed and Skin Extract and Ulva rigida Against Oxidative Stress Induced by Cisplatin on The Testis of Rats. Sakarya University Journal of Science, 24(2), 312-323. https://doi.org/10.16984/saufenbilder.638725
AMA Ksouri R, Rabah S, Mezghani S, Hamlaoui S. The Protective Effect of Grape Seed and Skin Extract and Ulva rigida Against Oxidative Stress Induced by Cisplatin on The Testis of Rats. SAUJS. April 2020;24(2):312-323. doi:10.16984/saufenbilder.638725
Chicago Ksouri, Rihab, Souha Rabah, Sana Mezghani, and Sonia Hamlaoui. “The Protective Effect of Grape Seed and Skin Extract and Ulva Rigida Against Oxidative Stress Induced by Cisplatin on The Testis of Rats”. Sakarya University Journal of Science 24, no. 2 (April 2020): 312-23. https://doi.org/10.16984/saufenbilder.638725.
EndNote Ksouri R, Rabah S, Mezghani S, Hamlaoui S (April 1, 2020) The Protective Effect of Grape Seed and Skin Extract and Ulva rigida Against Oxidative Stress Induced by Cisplatin on The Testis of Rats. Sakarya University Journal of Science 24 2 312–323.
IEEE R. Ksouri, S. Rabah, S. Mezghani, and S. Hamlaoui, “The Protective Effect of Grape Seed and Skin Extract and Ulva rigida Against Oxidative Stress Induced by Cisplatin on The Testis of Rats”, SAUJS, vol. 24, no. 2, pp. 312–323, 2020, doi: 10.16984/saufenbilder.638725.
ISNAD Ksouri, Rihab et al. “The Protective Effect of Grape Seed and Skin Extract and Ulva Rigida Against Oxidative Stress Induced by Cisplatin on The Testis of Rats”. Sakarya University Journal of Science 24/2 (April 2020), 312-323. https://doi.org/10.16984/saufenbilder.638725.
JAMA Ksouri R, Rabah S, Mezghani S, Hamlaoui S. The Protective Effect of Grape Seed and Skin Extract and Ulva rigida Against Oxidative Stress Induced by Cisplatin on The Testis of Rats. SAUJS. 2020;24:312–323.
MLA Ksouri, Rihab et al. “The Protective Effect of Grape Seed and Skin Extract and Ulva Rigida Against Oxidative Stress Induced by Cisplatin on The Testis of Rats”. Sakarya University Journal of Science, vol. 24, no. 2, 2020, pp. 312-23, doi:10.16984/saufenbilder.638725.
Vancouver Ksouri R, Rabah S, Mezghani S, Hamlaoui S. The Protective Effect of Grape Seed and Skin Extract and Ulva rigida Against Oxidative Stress Induced by Cisplatin on The Testis of Rats. SAUJS. 2020;24(2):312-23.

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