Research Article
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Year 2021, , 189 - 199, 01.02.2021
https://doi.org/10.16984/saufenbilder.831259

Abstract

References

  • 1. U. M. Rautakorpi, T. Klaukka, P. Honkanen, M. Mäkelä, T. Nikkarinen, E. Palva, R. Roine, H. Sarkkinen, P. Huovinen “Antibiotic Use by Indication: A Basis for Active Antibiotic Policy in the Community” Journal Scandinavian Journal of Infectious Diseases vol. 33, no. 12 pp.920-936, 2009.
  • 2. A.R. Gennaro, “Remington: The Science and Practice of Pharmacy”, Easton, PA, Mack Publishing Co vol. II, p. 1276 1995.
  • 3. Q. Zou, H. Song, M.Tang, K. Lu “Measurements of HO2 uptake coefficient on aqueous (NH4)2SO4 aerosol using aerosol flow tube with LIF system” Chinese Chemical Letters, vol 30, no 12, pp 2236-2240, 2019.
  • 4. M.J.B. Mengelers, P.E. Hougee, L.H.M. Janssen, A.S.J.P.A.M. Van Miert “Structure‐activity relationships between antibacterial activities and physicochemical properties of sulfonamides” Journal of Veterinary Pharmacology and Therapeutics vol.20, pp 276-283, 1997.
  • 5. Z. S. Mehdi “Analytical Method Development for the Spectrophotometric Determination of Sulfamethoxazole in Bulk Drug and Pharmaceutical Preparation” Journal of Chemistry and Biochemistry, vol. 3, no. 1, pp. 63-74, 2015.
  • 6. T. Horwedel, J.C Hagopian. L.J Bowman. “W.C Chapman. PGI17-Prevention of cytomegalovirus in liver transplant recipients before and after protocol change: a cost-effectiveness analysis” Value in Health vol. 17, no. 3, pp. A38, 2014.
  • 7. J. Robson, J. L. McKenzie, R. Cursons, G. M. Cook, V. L. Arcus. “The vap BC Operon from Mycobacterium smegmatis Is An Autoregulated Toxin–Antitoxin Module That Controls Growth via Inhibition of Translation” Journal of Molecular Biology, vol. 390, no. 3, pp. 339-578, 2009
  • 8. G. Geissler, E. Mutschler “Mutschler drug effects", Wissenschaftliche Verlagsgesellschaft mbH Stuttgard 9th edition 2008.
  • 9. R. Vardanyan V. Hruby “Synthesis of Essential Drugs” 1st Edition Elsevier Science Published 2006.
  • 10. M. Sanchez, P. F. Salinasa, M.C. Mahederoa, J.J. Aaronb. “Spectrofluorimetric determination of sulphonamides in pharmaceutical compounds and foods” Journal of Pharmaceutical and Biomedical Analysis, v. 10, no.10–12, pp. 805-808, 1992.
  • 11. H. Amini, A. Ahmadiani Journal of Pharmaceutical and Biomedical Analysis v.43 pp. 1146-1150, 2007,
  • 12. S. V. Temerev, “Determination of mercury in aquatic ecosystems” Journal of Analytical Chemistry, v. 63, no.3, pp. 292-296, 2008.
  • 13. D.H.Shewiyoab, E.Kaaleb, P.G.Rishab B.Dejaegherc, J.Smeyers–Verbekec Y, V. Heydenc. Journal of Chromatography A. v. 1216, no. 42, pp. 7102-7107, 2009.
  • 14. P. J. Gemperlinea, J. H. Cho, B. Bakera, B. Batchelor, D. S.Walker. “Determination of multicomponent dissolution profiles of pharmaceutical products by in situ fiber-optic UV measurements” Analytica Chimica Acta, v. 345, no. 1–3, pp. 155-159, 1997.
  • 15. M.H. Givianrad, M. Saber-Tehrani, P. Aberoomand-Azar, M. Mohagheghian “H-point standard additions method for simultaneous determination of sulfamethoxazole and trimethoprim in pharmaceutical formulations and biological fluids with simultaneous addition of two analytes” Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, v. 78, no. 3, pp. 1196-1200, 2011.
  • 16. Y. Dong, J. Li, X. Zhong, L. Cao, Q. Fan, “High-throughput prediction of tablet weight and trimethoprim content of compound sulfamethoxazole tablets for controlling the uniformity of dosage units by NIR” Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, v. 159, pp 78-82, 2016.
  • 17. A. Glyk, D. Solle,T. Scheper, S. Beutel, “Optimization of PEG–salt aqueous two-phase systems by design of experiments” Chemometrics and Intelligent Laboratory Systems, v. 149,pp.12-21, 2015.
  • 18. M. Akyüz, Ş.Ata, E. Dinç, “A chemometric optimization of method for determination of nitrosamines in gastric juices by GC–MS” Journal of Pharmaceutical and Biomedical Analysis v.117, pp. 26–36, 2016.

Method Development for the Chromatographic analysis of a Two-Component Tablet Formulation Using Chemometric Optimization Technique

Year 2021, , 189 - 199, 01.02.2021
https://doi.org/10.16984/saufenbilder.831259

Abstract

A new ultra-performance liquid chromatography (UPLC) method was improved for the determination of sulfamethoxazole and trimethoprim in a two-component tablet formulation. In the development of the UPLC method, the chromatographic conditions were chemometrically optimized by using the experimental design and optimization procedure. The central composite design and fitting model was applied to identify the suitable chromatographic conditions providing a desirable elution of sulfamethoxazole and trimethoprim in a chromatogram. In the central composite design, temperature, flow rate and buffer% were selected as the effective factors on the chromatographic resolution. The buffer system was the mixture of 0.1 M CH3COOH and CH3COONa (pH 4.75) in mobile phase system. In the optimization step, the chromatographic conditions were found to be 0.20 mL/min for flow rate, 38.0 °C for the column temperature and 66% for the acetate buffer system (v/v) in the mobile phase. Separation of the analyzed compounds was performed on a Waters BEH C18 column (100 mm-2.1 mm, 1.7 mm i.d.). In the validation step, recovery study was performed by applying the UPLC method to the synthetic binary mixture of sulfamethoxazole and trimethoprim. Recovery results were found as 99.12% for sulfamethoxazole and 99.44% for trimethoprim. The chemometric optimized UPLC method was applied to the quantitation of sulfamethoxazole and trimethoprim in commercial tablets.

References

  • 1. U. M. Rautakorpi, T. Klaukka, P. Honkanen, M. Mäkelä, T. Nikkarinen, E. Palva, R. Roine, H. Sarkkinen, P. Huovinen “Antibiotic Use by Indication: A Basis for Active Antibiotic Policy in the Community” Journal Scandinavian Journal of Infectious Diseases vol. 33, no. 12 pp.920-936, 2009.
  • 2. A.R. Gennaro, “Remington: The Science and Practice of Pharmacy”, Easton, PA, Mack Publishing Co vol. II, p. 1276 1995.
  • 3. Q. Zou, H. Song, M.Tang, K. Lu “Measurements of HO2 uptake coefficient on aqueous (NH4)2SO4 aerosol using aerosol flow tube with LIF system” Chinese Chemical Letters, vol 30, no 12, pp 2236-2240, 2019.
  • 4. M.J.B. Mengelers, P.E. Hougee, L.H.M. Janssen, A.S.J.P.A.M. Van Miert “Structure‐activity relationships between antibacterial activities and physicochemical properties of sulfonamides” Journal of Veterinary Pharmacology and Therapeutics vol.20, pp 276-283, 1997.
  • 5. Z. S. Mehdi “Analytical Method Development for the Spectrophotometric Determination of Sulfamethoxazole in Bulk Drug and Pharmaceutical Preparation” Journal of Chemistry and Biochemistry, vol. 3, no. 1, pp. 63-74, 2015.
  • 6. T. Horwedel, J.C Hagopian. L.J Bowman. “W.C Chapman. PGI17-Prevention of cytomegalovirus in liver transplant recipients before and after protocol change: a cost-effectiveness analysis” Value in Health vol. 17, no. 3, pp. A38, 2014.
  • 7. J. Robson, J. L. McKenzie, R. Cursons, G. M. Cook, V. L. Arcus. “The vap BC Operon from Mycobacterium smegmatis Is An Autoregulated Toxin–Antitoxin Module That Controls Growth via Inhibition of Translation” Journal of Molecular Biology, vol. 390, no. 3, pp. 339-578, 2009
  • 8. G. Geissler, E. Mutschler “Mutschler drug effects", Wissenschaftliche Verlagsgesellschaft mbH Stuttgard 9th edition 2008.
  • 9. R. Vardanyan V. Hruby “Synthesis of Essential Drugs” 1st Edition Elsevier Science Published 2006.
  • 10. M. Sanchez, P. F. Salinasa, M.C. Mahederoa, J.J. Aaronb. “Spectrofluorimetric determination of sulphonamides in pharmaceutical compounds and foods” Journal of Pharmaceutical and Biomedical Analysis, v. 10, no.10–12, pp. 805-808, 1992.
  • 11. H. Amini, A. Ahmadiani Journal of Pharmaceutical and Biomedical Analysis v.43 pp. 1146-1150, 2007,
  • 12. S. V. Temerev, “Determination of mercury in aquatic ecosystems” Journal of Analytical Chemistry, v. 63, no.3, pp. 292-296, 2008.
  • 13. D.H.Shewiyoab, E.Kaaleb, P.G.Rishab B.Dejaegherc, J.Smeyers–Verbekec Y, V. Heydenc. Journal of Chromatography A. v. 1216, no. 42, pp. 7102-7107, 2009.
  • 14. P. J. Gemperlinea, J. H. Cho, B. Bakera, B. Batchelor, D. S.Walker. “Determination of multicomponent dissolution profiles of pharmaceutical products by in situ fiber-optic UV measurements” Analytica Chimica Acta, v. 345, no. 1–3, pp. 155-159, 1997.
  • 15. M.H. Givianrad, M. Saber-Tehrani, P. Aberoomand-Azar, M. Mohagheghian “H-point standard additions method for simultaneous determination of sulfamethoxazole and trimethoprim in pharmaceutical formulations and biological fluids with simultaneous addition of two analytes” Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, v. 78, no. 3, pp. 1196-1200, 2011.
  • 16. Y. Dong, J. Li, X. Zhong, L. Cao, Q. Fan, “High-throughput prediction of tablet weight and trimethoprim content of compound sulfamethoxazole tablets for controlling the uniformity of dosage units by NIR” Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, v. 159, pp 78-82, 2016.
  • 17. A. Glyk, D. Solle,T. Scheper, S. Beutel, “Optimization of PEG–salt aqueous two-phase systems by design of experiments” Chemometrics and Intelligent Laboratory Systems, v. 149,pp.12-21, 2015.
  • 18. M. Akyüz, Ş.Ata, E. Dinç, “A chemometric optimization of method for determination of nitrosamines in gastric juices by GC–MS” Journal of Pharmaceutical and Biomedical Analysis v.117, pp. 26–36, 2016.
There are 18 citations in total.

Details

Primary Language English
Journal Section Research Articles
Authors

Faysal Selimoğlu 0000-0003-3798-9054

Betül Sarıtaş This is me 0000-0001-9701-2523

Erdal Dinç 0000-0001-6326-1441

Publication Date February 1, 2021
Submission Date November 25, 2020
Acceptance Date December 21, 2020
Published in Issue Year 2021

Cite

APA Selimoğlu, F., Sarıtaş, B., & Dinç, E. (2021). Method Development for the Chromatographic analysis of a Two-Component Tablet Formulation Using Chemometric Optimization Technique. Sakarya University Journal of Science, 25(1), 189-199. https://doi.org/10.16984/saufenbilder.831259
AMA Selimoğlu F, Sarıtaş B, Dinç E. Method Development for the Chromatographic analysis of a Two-Component Tablet Formulation Using Chemometric Optimization Technique. SAUJS. February 2021;25(1):189-199. doi:10.16984/saufenbilder.831259
Chicago Selimoğlu, Faysal, Betül Sarıtaş, and Erdal Dinç. “Method Development for the Chromatographic Analysis of a Two-Component Tablet Formulation Using Chemometric Optimization Technique”. Sakarya University Journal of Science 25, no. 1 (February 2021): 189-99. https://doi.org/10.16984/saufenbilder.831259.
EndNote Selimoğlu F, Sarıtaş B, Dinç E (February 1, 2021) Method Development for the Chromatographic analysis of a Two-Component Tablet Formulation Using Chemometric Optimization Technique. Sakarya University Journal of Science 25 1 189–199.
IEEE F. Selimoğlu, B. Sarıtaş, and E. Dinç, “Method Development for the Chromatographic analysis of a Two-Component Tablet Formulation Using Chemometric Optimization Technique”, SAUJS, vol. 25, no. 1, pp. 189–199, 2021, doi: 10.16984/saufenbilder.831259.
ISNAD Selimoğlu, Faysal et al. “Method Development for the Chromatographic Analysis of a Two-Component Tablet Formulation Using Chemometric Optimization Technique”. Sakarya University Journal of Science 25/1 (February 2021), 189-199. https://doi.org/10.16984/saufenbilder.831259.
JAMA Selimoğlu F, Sarıtaş B, Dinç E. Method Development for the Chromatographic analysis of a Two-Component Tablet Formulation Using Chemometric Optimization Technique. SAUJS. 2021;25:189–199.
MLA Selimoğlu, Faysal et al. “Method Development for the Chromatographic Analysis of a Two-Component Tablet Formulation Using Chemometric Optimization Technique”. Sakarya University Journal of Science, vol. 25, no. 1, 2021, pp. 189-9, doi:10.16984/saufenbilder.831259.
Vancouver Selimoğlu F, Sarıtaş B, Dinç E. Method Development for the Chromatographic analysis of a Two-Component Tablet Formulation Using Chemometric Optimization Technique. SAUJS. 2021;25(1):189-9.

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