Synthesis and Characterization of Thiazole Compounds in the Presence of Various Reagents, Catalysts and Solvents

Year 2022, , 757 - 767, 31.08.2022

Nurcan Berber

https://doi.org/10.16984/saufenbilder.950016

Abstract

The reaction medium plays a key role in organic synthesis and pharmaceutical research. There are many opinions on choosing the best condition, including cost and environmental implications, but the main requirement is that they have the necessary interaction with solvents to cause dissolution, precipitation, stabilization, or instability. For this purpose, in this article synthesis of the thiazole ring was made under various reaction conditions. So new compounds 2-(isoquinolin-5-ylimino)-3-phenylthiazolidin-4-one (1), (4-amino-3-phenylthiazol-2(3H)-ylidene) isoquinolin-5-amine (2), (4-amino-3-phenylthiazol-2(3H)-ylidene) isoquinolin-5-amine (3) were synthesized from the reaction between thiourea derivative and monochloroacetic acid, diethyloxalate and chloro acetonitrile. For this synthesizes were created in various reaction conditions, using different bases (sodium acetate/sodyum etoksit/ triethylamine or pyridine) and solvents (1,4-dioxane, toluene, acetic acid, ethanol, tetrahydrofuran, dimethyl formamide). At the end of these reactions, the best efficiency was obtained with the one-pot reaction using THF/DMF, Et3N. The structures of all novel compounds reported herein were established using FT-IR, 1H NMR, and 13C NMR spectra as well as elemental analysis technique.

Keywords

5-aminoisoquinoline, thioureas, thiazole rings, one-pot reaction

Supporting Institution

Çanakkale Onsekiz Mart Üniversitesi

Project Number

FHD-2020-3440

Thanks

The author would like to thank the Çanakkale Onsekiz Mart University Scientific Research Projects Commission (BAP) for contributing to the financial portion of the project.

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