Hollow Fiber Liquid Phase Microextraction

Year 2013, Volume: 17 Issue: 1, 17 - 26, 01.04.2013

Erol Alver Ayla Demirci Mustafa Özcimder

Abstract

Even though high precision analytical devices are developed in qualitative and quantitative determination of substance or substances in matrix samples (biological, environmental, food etc.), analytical devices mostly fail determining in matrix environment. Due to such reasons, clean-up process is needed to take (purification) and concentrate (enrichment) the substance in matrix environment. Liquid-liquid (LLE) extraction is commonly used in preparation of the samples. In recent years, liquid phase micro extraction (LPME) methods minimizing organic solvent used in liquidliquid extraction are developed. Of these methods, hollow fiber liquid phase micro extraction (HF–LPME) is widely used.

Keywords

Hollow fiber liquid phase microextraction, HF–LPME, Sample preparation, Organic pollutants

Oyuk (Hollow) Fiber Sıvı Faz Mikroekstraksiyon

Abstract

Even though high precision analytical devices are developed in qualitative and quantitative determination of substance or substances in matrix samples (biological, environmental, food etc.), analytical devices mostly fail determining in matrix environment. Due to such reasons, clean-up process is needed to take (purification) and concentrate (enrichment) the substance in matrix environment. Liquid-liquid (LLE) extraction is commonly used in preparation of the samples. In recent years, liquid phase micro extraction (LPME) methods minimizing organic solvent used in liquid-liquid extraction are developed. Of these methods, hollow fiber liquid phase micro extraction (HFLPME) is widely used.

Keywords

Oyuk (hollow) fiber sıvı faz mikroekstraksiyon, HF–LPME, Örnek hazırlama, Organik kirleticiler

References

• Pestisit Su İkili Faz GC-MS 1 Pestisit Deniz suyu İkili Faz GC-MS Pestisit Sebze Üçlü Faz LC-MS 2 İnsektisit Su İkili Sistem GC-FTD 3 PAH Su İkili Faz GC-MS PAH Su Tepe Boşluklu GC-MS PAH Su, Toprak Üçlü Faz GC-FID 4 PAH Toprak İkili Faz GC-FID PAH Çam İğnesi İkili Faz GC-MS PAH Atık Su İkili faz GC-MS Fenoksi Herbisit İnek Sütü Üçlü Faz HPLC-UV 5 Triazin Herbisit Toprak İkili faz GC-MS Fungusit Portakal Suyu Üçlü Faz LC-MS Fenolik Asit Meyve Suyu Üçlü Faz HPLC-DAD 6 Nitrofenol Deniz Suyu Üçlü Faz LC-UV Fenol Su Üçlü Faz CE(MEKC) 7 Fenol Deniz suyu İkili faz GC-MS Aromatik amin Su Üçlü Faz CE Aromatik amin Su Üçlü Faz HPLC Florokinolon Su, Hayvan İdrarı Üçlü Faz HPLC-DAD/FD 8 Sülfonamit Su Üçlü Faz HPLC-DAD/FD İlaç İdrar, Plazma Üçlü Faz HPLC-UV İlaç İdrar, Plazma Üçlü Faz ESI-IMS 9 İlaç Kan Üçlü Faz LC-MS İlaç Arıtma Çamuru Üçlü Faz LC-MS İlaç Atık Su Üçlü Faz LC-MS-MS İlaç Su, Plazma Üçlü Faz CE İlaç İdrar, Plazma Üçlü Faz CE İlaç İdrar,Su Üçlü Faz CE-DAD/UV 10 Pb, Ni Su İkili Faz ETAAS 11 Cu, Zn, Pd, Cd, Hg, Pb, Bi Serum As(III), As(V) İçme Suyu, Saç İkili Faz ETAAS Uçuçu Selenyum Bileşikleri Su, toprak Metil-Hg Saç, Çamur İkili Faz GFAAS 13 1) GC-MS: Gaz Kromatograf- Kütle Spektrometresi 2) LC-MS: Sıvı Kromatograf- Kütle Spektrometresi 3) GC-FTD: Gaz Kromatograf-Termiyonik Detektör (Nitrojen-Fosfor Detektör, NPD) 4) GC-FID: Gaz Kromatograf-Alev İyonlaşma Detektörü 5) HPLC-UV: Yüksek Basınç Sıvı Kromatograf-UV Detektör 6) HPLC-DAD: Yüksek Basınç Sıvı Kromatograf-Diode Array Detektör 7) MEKC: Misel Elektrokinetik Kromatografi 8) HPLC-DAD/FD: Yüksek Basınç Sıvı Kromatograf-Diode Array/Floresan Detektör 9) ESI-IMS: Elektrosprey İyonizasyon-İyon Mobilite Spektrometresi 10) CE-DAD/Kapiler Elektroforez- Diode Array/UV Detektör 11) ETAAS: Elektrotermal Atomik Absorpsion Spektrometresi 12) ETV-ICP/MS: Elektrotermal Buharlaşma-İndüktif Optik Plazma Kütle Spektrometresi 13) GFAAS: Grafit Fırınlı Atomik Absorpsion Spektrometresi SONUÇ HF–LPME basit, hızlı, ucuz ve yüksek oranda seçici ve yüksek zenginleştirme faktörüne sahip bir yöntemdir. Oyuk fiber mikroekstraksiyon yöntemi çevresel, biyolojik, gıda örneklerinde ve asidik ve bazik ilaç analizlerinde zenginleştirmenin yanı sıra ön temizleme işlemini de aynı anda yaparak kullanılabilir. Fiber, alıcı fazın örnek çözelti ile doğrudan temasnı kestiğinden dolayı, şiddetli karıştırma hızlarında ekstraksiyon çözücüsü kaybını en az düzeylere indirir. Polipropilen fiber çok ucuz bir maliyete sahiptir. Bu nedenle, her analizde bir kez kullanılır. Fiberin her analizde bir kez kullanılması, önceki analizlerden kirlilik gelmesini engeller. Polipropilen hollow fiber küçük gözeneklere sahip olduğu için, matriks ortamdaki büyük molekül ağırlıklı kirliliklerin alıcı faza girmesini engelleyerek iyi bir ön temizleme işlemi yapar [2,13,22,29,67,71]. Yöntem, alıcı faz ile verici faz arasındaki membran bariyerin ekstraksiyon etkinliğini azaltması ve ekstraksiyon süresini uzatması, fiberin yüzeyinde hava kabarcıklarının oluşması ile ekstraksiyon etkinliği ve yinelenebilirliğin azaltması, gerçek örnek analizlerinde matriksin (kan, plazma, atık su) fiber üzerindeki gözenekleri tıkayabilmesi gibi dezavantajlara sahiptir [22,72,73]. KAYNAKLAR Krylov, V.A., Krylov, A.V, Mosyagin, P.V., Matkivskaya, Y.O., “Liquid–Phase Microextraction Preconcentration of Impurities”, Journal of Analytical Chemistry, 66, 331–350, (2011).
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