TERATOLOGIC EFFECTS OF BISPHENOL A ON ZEBRAFISH (Danio rerio)

Year 2013, Volume: 17 Issue: 1, 105 - 111, 01.04.2013

Cansu Akbulut Nazan Deniz Koç

Abstract

Zebrafish (Danio rerio) has easy reproductive capacity and transparent embryos and therefore generally preffered for scientific studies as a vertebrate model. Because of bisphenol A is produced too much and used for making plastics, many organisms including human are exposed to this substance. Bisphenol A has estrogenic activity and thus it effects fertility. So, in our study, effects of low doses of bisphenol A (4mg/L and 8 mg/L) on embryo and larva development was investigated.

Keywords

Bisphenol A, zebrafish, embryo

BİSFENOL A'NIN ZEBRA BALIKLARINDA (Danio rerio) TERATOLOJİK ETKİLERİ

Abstract

Zebrafish (Danio rerio) has easy reproductive capacity and transparent embryos and therefore generally preffered for scientific studies as a vertebrate model. Because of bisphenol A is produced too much and used for making plastics, many organisms including human are exposed to this substance. Bisphenol A has estrogenic activity and thus it effects fertility. So, in our study, effects of low doses of bisphenol A (4mg/L and 8 mg/L) on embryo and larva development was investigated.

Keywords

Bisfenol A, zebra balığı, embriyo

References

• KIMMEL, C.B., BALLARD W.W., KIMMEL S.R., ULLMANN B., SCHILLING T.F., Stages of Embryonic Development of Zebrafish, Developmental Dynamics, 203: 253-310, 1995.
• GOLDMAN, JM., LAWS, SC., BALCHAK, SK., COOPER, RL., KAVLOCK, RJ., Endocrine-disrupting Chemicals: Pre-pubertal Exposures and Effects on Sexual Maturation and Thyroid Activity in the Female Rat. A Focus on the Edstac Recommendations, Critical Reviews in Toxicology, 30: 135-196, 2000.
• STOKER, TE., PARKS, LG., GRAY, LE., COOPER, RL., Endocrine-disrupting chemicals: Prepubertal exposures and effects on sexual maturation and thyroid function in the male rat, A focus on the EDSTAC recommendations, Endocrine Disrupter Screening and Testing Advisory Committee, Critical Reviews in Toxicology, 30: 197–252, 2000.
• LEE, MM., Endocrine Disrupters, A Current Review of Pediatric Endocrinology, 109-118, 2007.
• DURMAZ, E., ÖZMERT, EN., Fitalatlar ve Çocuk Sağlığı, Çocuk Sağlığı ve Hastalıkları Dergisi, 53: 305317, 2010.
• DIANIN, AP., Zhurnal russkogo fizikokhimicheskogo obshchestva. 23, 492, 1891.
• DODDS, E., LAWSON, W., Synthetic, oestrogenic agents without the phenanthrene nucleus, Nature, 137: 996, 1936.
• STAPLES, CA., DORN, PB., KLECKA, GM., O’BLOCK, ST., A Review of The Environmental Fate, Effects and Exposures of Bisphenol A, Chemosphere, 36(10): 2149- 2173, 1998.
• JOHNSON, I., HARVEY, P., Study on The Scientific Evaluation of 12 Substances In The Context of Endocrine Disrupter Priority List of Actions European Commission, Wrc-Nsf Ref: Uc 6052, 2002.
• KOSKY, P.E., GUGGENHEİM, E.K., The Aqueous Phase in the Interfacial Sythesis of Polycarbonates. 1. Ionic Equilibra and Experhnental Solubilities in the BPA-NaOH-H 2 O System Industrial and. Engineering. Chemistry. Research. 30(3): 462-467, 19 MIHAICH, E.M., FRIDERICH, U., CASPERS, N., HALL, A.T., KLECKA, G.M., DIMOND, S.S, STAPLES, C.A., ORTEGO, L.S., HENTGES, S.G., Acute and chronic toxicity testing of bisphenol A with aquatic invertebratas and plants, Ecotoxicology and Environmental Safety, 72: 1392-1399, 2009.
• HENGSTLER, J G., FOTH, H., GEBEL, T., KRAMER, PJ., LILIENBLUM, W., SCHWEINFURTH, H., VÖLKEL, W., WOLLIN, KM., GUNDERT-REMY, U., Critical Evaluation of Eey evidence on The Human Health Hazards of Exposure to Bisphenol A, Critical Reviews in Toxicology, 41(4): 263-291,2011.
• WELSHONS, WV., NAGEL, SC., VOM SAAL, FS., Large Effects from Small Exposures. III. Endocrine Mechanisms Mediating Effects of Bisphenol A at Levels of Human Exposure, Endocrinology 147(6): 5669, 2006.
• MILLS, D., Akvaryum Bakımı, İnkılap Kitabevi, İstanbul, Türkiye, 1994.
• DUAN, ZH., ZHU, L., Toxicity of Bisphenol A on the Growth of zebrafish Embryos, Acta Hydrobiologica Sinica, 30:6, 638-642, 2006.
• DODGE, JA., GLASEBROOK, AL., MAGEE, DE., ve ark., Environmental estrogens: effects on cholesterol lowering and bone in the ovariectomized rat, The Journal of Steroid Biochemistry and Molecular Biology, 59: 155-161, 1996.
• COLERANGLE, JB., ROY, D., Profound effects of the weak environmental estrogen-like chemical bisphenol a on the growth of the mammary gland of Noble rats, The Journal of Steroid Biochemistry and Molecular Biology, 60: 153-160, 1997.
• LAWSON, C., GIESKE, M., MURDOCH, B., YE, P., LI, Y., HASSOLD, T., HUNT, P., Gene expression in the fetal Mouse ovary is altered by exposure to low doses of bisphenol A, Biology of Reproduction, 84(1): 79-86, 2010.
• DONG, W., TERAOKA, H., YAMAZAKİ, K., TSUKİYAMA, S., IMANİ, S., IMAGAWA, T., STEGEMAN, JJ., PETERSON, RE., HİRAGA, T., 2,3,7,8-Tetrachlorodibenzo-p-dioxin Toxicity in the Zebrafish Embryo: Local Circulation Failure in the Dorsal Midbrain Is Associated with Increased Apoptosis, Toxicological Sciences, 69(1): 191-201, 200 WILLEY, JB., KRONE PH., Effects of endosulfan and nonylphenol on the primordial germ cell population in pre-larval zebrafish embryos, Aquatic Toxicology, 54(1-2): 113-123, 2001.