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Biomedical applications of polyglycolic acid (PGA)

Year 2017, Volume: 21 Issue: 6, 1237 - 1244, 01.12.2017
https://doi.org/10.16984/saufenbilder.283156

Abstract

Biodegradable polymers have a great potential and widely
used in biomedical applications due to their biodegradability and
biocompatibility. Biodegradable polymers contain hydrolytically unstable
functional groups (such as esters, anhydrides and etc.) in their backbone.
These hydrolytically unstable functional groups can be hydrolyzed, or eaten by
microorganisms, and degradability happens. Biodegradable polymers can be
effectively used for several biomedical applications such as drug delivery,
dental, orthopedic and tissue engineering. Polyglycolic acid (PGA) is a desired
material for physicians due to its excellent degradation behaviour. However,
limited research based on PGA polymers has been studied in biomedical
applications due to insolubility of PGA in most of the solvents and rapid
degradation of PGA. This review will focus on the improvements made in the
development of hydrolytically degradable PGA in biomedical fields.

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Poliglikolik Asit’ in (PGA) Biyomedikal uygulamaları

Year 2017, Volume: 21 Issue: 6, 1237 - 1244, 01.12.2017
https://doi.org/10.16984/saufenbilder.283156

Abstract

Biyobozunur
polimerler, biyobozunurluk ve biyouyumluluk özelliklerinden dolayı biyomedikal uygulamalarda
büyük potansiyele sahip olup yaygın şekilde kullanılmaktadır. Biyobozunur
polimerler yapılarında hidrolitik olarak kararsız fonksiyonel gruplar (örneğin,
esterler, anhidritler vd.) içerirler. Bu hidrolitik olarak kararsız gruplar
kolayca hidroliz olabilmekte, veya mikroorganizmalar tarafından
yenilebilmektedir. Bu sayede polimerlerin bozunması gerçekleşir. Biyobozunur
polimerler birçok biyomedikal alanda (örneğin; ilaç salınımı, dişçilik,
ortopedi, ve doku mühendisliği) etkili bir biçimde kullanılabilmektedir.
Poliglikolik asit (PGA) oldukça iyi bozunma davranışından dolayı tıp alanında
yaygın şekilde kullanılan bir materyaldir. Ancak, PGA polimerlerinin
biyomedikal uygulamaları alanında sınırlı sayıda araştırma mevcuttur. PGA
birçok çözücü içerisinde çözünememekte ve hızlı bir şekilde bozunmaya
uğramaktadır. Bu derleme hidrolitik olarak bozunabilen PGA’ nın biyomedikal
alanda kullanımındaki yenilikleri açıklayacaktır.


















References

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  • 10. E. Göktürk, A. G. Pemba, and S. A. Miller. (28 April 2015). Polyglycolic acid from the direct polymerization of renewable C1 feedstocks. Polym. Chem. [online]. 6, pp. 3918–3925. Available: http://pubs.rsc.org/en/Content/ArticleLanding/2015/PY/c5py00230c#!divAbstract.
  • 11. P. Dobrzynski, J. Kasperczyk, and B. Maciej. (18 June 1999). Application of Calcium Acetylacetonate to the Polymerization of Glycolide and Copolymerization of Glycolide with ε–Caprolactone and L-Lactide. Macromolecules. [online]. 32(14), pp. 4735–4737. Available: http://pubs.acs.org/doi/abs/10.1021/ma981969z.
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  • 13. A. R. Katz and R. J. Turner. (October 1970). Evaluation of tensile and absorption properties of polyglycolic acid sutures. Surg. Gynecol. Obstet. [online]. 131(4), pp. 701–716. Available: https://www.ncbi.nlm.nih.gov/pubmed/5458531.
  • 14. Kuredux Polyglycolic Acid (PGA) Resin, A New Polymer Option, [online]. Available: http://www.kureha.com/product-groups/pga.htm.
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  • 18. O. Bostman, E. Hirvensalo, S. Vainionpaa, A. Makela, K. Vihtonen, P. Tormala, and P. Rokkanen. (January 1989). Ankle fractures treated using biodegradable internal fixation. Clin. Orthop. Related Res. [online]. 238, pp. 195-203. Available: http://journals.lww.com/corr/Abstract/1989/01000/Ankle_Fractures_Treated_Using_Biodegradable.28.aspx.
  • 19. O. Bostman, E. Hirvensalo, S. Vainionpaa, K. Vihtonen, P. Tormala, and P. Rokkanen. (1990). Degradable polyglycolide rods for the internal fixation of displaced bimalleolar fractures. Int. Orthop. (SICOT). [online]. 14(1), pp: 1-8. Available: https://www.ncbi.nlm.nih.gov/pubmed/2160439.
  • 20. E. Hirvensalo. (October 1989). Fracture fixation with biodegradable rods. Forty-one cases of severe ankle fractures. Acta Orthop. Stand. [online]. 60(5), pp. 601-606. Available: https://www.ncbi.nlm.nih.gov/pubmed/2557718.
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  • 23. B. K. Behera. (25 November 2013). Pharmaceutical Applications of Lactides and Glycolides: A Review. Journal of Medical and Pharmaceutical Innovation. [online]. 1(1), pp. 1-5. Available: http://www.jmedpharm.com/index.php?journal=JMPI&page=article&op=view&path%5B%5D=4.
  • 24. D. Gilding and A. M. Reed. (December 1979). Biodegradable polymers for use in surgery-polyglycolic/poly(lactic acid) homo- and copolymers: 1. Polymer. [online]. 20(12), pp. 1459-1464. Available: http://www.sciencedirect.com/science/article/pii/0032386179900090.
  • 25. I. P. Matthews, C. Gibson, and A. H. Samuel. (13 September 1989). Enhancement of the kinetics of the aeration of ethylene oxide sterilized polymers using microwave radiation. J. Biomed. Mater. Res. [online]. 23(2), pp. 143-156. Available: http://onlinelibrary.wiley.com/doi/10.1002/jbm.820230202/pdf.
  • 26. Y. Chen, L. Tan, L. Chen, Y. Yang, and X. Wang. (June 2008). Study on Biodegradable Aromatic/Aliphatic Copolyesters. Brazilian Journal of Chemical Engineering. [online]. 25(02), pp. 321-335. Available: http://www.scielo.br/pdf/bjce/v25n2/a11v25n2.pdf.
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There are 50 citations in total.

Details

Subjects Engineering
Journal Section Research Articles
Authors

Ersen Göktürk

Hüseyin Erdal

Publication Date December 1, 2017
Submission Date January 3, 2017
Acceptance Date June 1, 2017
Published in Issue Year 2017 Volume: 21 Issue: 6

Cite

APA Göktürk, E., & Erdal, H. (2017). Biomedical applications of polyglycolic acid (PGA). Sakarya University Journal of Science, 21(6), 1237-1244. https://doi.org/10.16984/saufenbilder.283156
AMA Göktürk E, Erdal H. Biomedical applications of polyglycolic acid (PGA). SAUJS. December 2017;21(6):1237-1244. doi:10.16984/saufenbilder.283156
Chicago Göktürk, Ersen, and Hüseyin Erdal. “Biomedical Applications of Polyglycolic Acid (PGA)”. Sakarya University Journal of Science 21, no. 6 (December 2017): 1237-44. https://doi.org/10.16984/saufenbilder.283156.
EndNote Göktürk E, Erdal H (December 1, 2017) Biomedical applications of polyglycolic acid (PGA). Sakarya University Journal of Science 21 6 1237–1244.
IEEE E. Göktürk and H. Erdal, “Biomedical applications of polyglycolic acid (PGA)”, SAUJS, vol. 21, no. 6, pp. 1237–1244, 2017, doi: 10.16984/saufenbilder.283156.
ISNAD Göktürk, Ersen - Erdal, Hüseyin. “Biomedical Applications of Polyglycolic Acid (PGA)”. Sakarya University Journal of Science 21/6 (December 2017), 1237-1244. https://doi.org/10.16984/saufenbilder.283156.
JAMA Göktürk E, Erdal H. Biomedical applications of polyglycolic acid (PGA). SAUJS. 2017;21:1237–1244.
MLA Göktürk, Ersen and Hüseyin Erdal. “Biomedical Applications of Polyglycolic Acid (PGA)”. Sakarya University Journal of Science, vol. 21, no. 6, 2017, pp. 1237-44, doi:10.16984/saufenbilder.283156.
Vancouver Göktürk E, Erdal H. Biomedical applications of polyglycolic acid (PGA). SAUJS. 2017;21(6):1237-44.

Sakarya University Journal of Science (SAUJS)