Biomedical applications of polyglycolic acid (PGA)

Yıl 2017, Cilt: 21 Sayı: 6, 1237 - 1244, 01.12.2017

Ersen Göktürk , Hüseyin Erdal

https://doi.org/10.16984/saufenbilder.283156

Cited By: 5

Öz

Biodegradable polymers have a great potential and widely
used in biomedical applications due to their biodegradability and
biocompatibility. Biodegradable polymers contain hydrolytically unstable
functional groups (such as esters, anhydrides and etc.) in their backbone.
These hydrolytically unstable functional groups can be hydrolyzed, or eaten by
microorganisms, and degradability happens. Biodegradable polymers can be
effectively used for several biomedical applications such as drug delivery,
dental, orthopedic and tissue engineering. Polyglycolic acid (PGA) is a desired
material for physicians due to its excellent degradation behaviour. However,
limited research based on PGA polymers has been studied in biomedical
applications due to insolubility of PGA in most of the solvents and rapid
degradation of PGA. This review will focus on the improvements made in the
development of hydrolytically degradable PGA in biomedical fields.

Anahtar Kelimeler

Biodegradable polymers, biomedical applications, biodegradability, biocompatibility, polyglycolic acid (PGA), biocompatibility

Poliglikolik Asit’ in (PGA) Biyomedikal uygulamaları

Öz

Biyobozunur
polimerler, biyobozunurluk ve biyouyumluluk özelliklerinden dolayı biyomedikal uygulamalarda
büyük potansiyele sahip olup yaygın şekilde kullanılmaktadır. Biyobozunur
polimerler yapılarında hidrolitik olarak kararsız fonksiyonel gruplar (örneğin,
esterler, anhidritler vd.) içerirler. Bu hidrolitik olarak kararsız gruplar
kolayca hidroliz olabilmekte, veya mikroorganizmalar tarafından
yenilebilmektedir. Bu sayede polimerlerin bozunması gerçekleşir. Biyobozunur
polimerler birçok biyomedikal alanda (örneğin; ilaç salınımı, dişçilik,
ortopedi, ve doku mühendisliği) etkili bir biçimde kullanılabilmektedir.
Poliglikolik asit (PGA) oldukça iyi bozunma davranışından dolayı tıp alanında
yaygın şekilde kullanılan bir materyaldir. Ancak, PGA polimerlerinin
biyomedikal uygulamaları alanında sınırlı sayıda araştırma mevcuttur. PGA
birçok çözücü içerisinde çözünememekte ve hızlı bir şekilde bozunmaya
uğramaktadır. Bu derleme hidrolitik olarak bozunabilen PGA’ nın biyomedikal
alanda kullanımındaki yenilikleri açıklayacaktır.

Anahtar Kelimeler

Biyobozunur polimerler, poliglikolik asit (PGA), biyomedikal uygulamalar, biyobozunurluk, biyouyumluluk, biyouyumluluk

Kaynakça

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