Measurement of the Penetration Depth in Biological Tissue for Different Optical Powers

Year 2018, Volume: 22 Issue: 4, 1095 - 1100, 01.08.2018

Halil Arslan , Yaşar Barış Doluğan , Ayşe Nur Ay

https://doi.org/10.16984/saufenbilder.332802

Cited By: 3

Abstract

In photodynamic therapy, the knowledge of the penetration depth for the
light is needed in order to ensure that the optical energy received by the
tumorous tissue. In this study, the optical penetration depths of 635 nm laser
light in chicken breast tissue have been measured by using 8 tissue samples
with different thicknesses between 2.5 mm and 9.0 mm. Transmitted light
intensities through the tissue samples have been measured with 11 different
optical power values in the range of 130mW – 660mW. Measurement results for
each power value have been analyzed according to the Beer-Lambert law. With the
help of statistical analyzes, it has been determined that the optical
penetration depth of the light in biological tissue does not depend on its
optical power.

Keywords

PDT, Penetration depth, Beer-Lambert law

Biyolojik Dokulardaki Penetrasyon Derinliklerinin Farklı Optik Güç Değerleri İçin Ölçülmesi

Abstract

Fotodinamik Terapi’de (PDT), tümörlü doku tarafından alınan
optik enerjinin yeterli olup olmadığının belirlenebilmesi için ışığın doku
içindeki penetrasyon derinliğinin bilinmesi gereklidir. Bu çalışmada, 635 nm
lazer ışığının tavuk göğsü dokusundaki penetrasyon derinliği 2.5 mm ile 9.0 mm
arasında değişen farklı kalınlıklarda 8 doku örneği kullanılarak ölçülmüştür. Doku
örneklerinde iletilen ışık yoğunlukları 130mW – 660mW aralığındaki 11 farklı
optik güç değeri için ölçülmüştür. Her bir güç değeri için ölçüm sonuçları
Beer-Lambert yasasına göre analiz edilmiştir. İstatistiksel analizler
yardımıyla, biyolojik dokudaki penetrasyon derinliğinin optiksel güce bağlı
olmadığı saptanmıştır.

Keywords

FDT, Penetrasyon derinliği, Beer-Lambert Yasası

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