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Year 2021, Volume: 25 Issue: 3, 647 - 662, 30.06.2021
https://doi.org/10.16984/saufenbilder.742432

Abstract

References

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Determination of Phenolic Compounds, Organic Volatile Molecules and Anti-Cancer Properties in Inula Viscosa L., Viscum Album L. and Raphanus Sativus L.

Year 2021, Volume: 25 Issue: 3, 647 - 662, 30.06.2021
https://doi.org/10.16984/saufenbilder.742432

Abstract

The plants elecampane (Inula Viscosa L.), mistel (Viscum album L.) and black radish seed (Raphanus Sativus L.) have been used in the treatment of common diseases worldwide as part of traditional medicine for many years. Especially in Turkey, elecampane plant is commonly used as remedy of cancer. In this study, phytochemical components of these three plants were analyzed using liquid chromatography-mass spectrometer/mass spectrometer and gas chromatography-mass spectrometer techniques. Antioxidant activity of the characterized extracts were evaluated using DPPH assay, followed by biological properties were studied using MDA-MB-231 breast cancer line. Differences in the chemical compositions of the extracts resulted in alteration in antioxidant potentials, where elecampane gave the highest antioxidant activity while black radish seed extracts did not provide any meaningful results within the test period. Cytotoxicity studies showed that chemical composition is of the most prominent factor that defined the IC50 value of each extract, where pro-oxidant and antioxidant affects were observed in relation to presence of flavonoids. Mistel extract was further tested for wound healing and apoptosis tests, and the extract was obtained as a trigger for both apoptosis and wound-healing. The findings can be a basis for refinement as fractionation of the mistel and elecampane extracts so as to obtain the best mixture that can serve as strong anticancer agent mixture.

References

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There are 75 citations in total.

Details

Primary Language English
Journal Section Research Articles
Authors

Hafize Dilek Tepe 0000-0002-6035-6901

Aslı Uğurlu This is me 0000-0003-2131-2823

İdris Yazgan 0000-0002-0264-1253

Publication Date June 30, 2021
Submission Date May 25, 2020
Acceptance Date April 5, 2021
Published in Issue Year 2021 Volume: 25 Issue: 3

Cite

APA Dilek Tepe, H., Uğurlu, A., & Yazgan, İ. (2021). Determination of Phenolic Compounds, Organic Volatile Molecules and Anti-Cancer Properties in Inula Viscosa L., Viscum Album L. and Raphanus Sativus L. Sakarya University Journal of Science, 25(3), 647-662. https://doi.org/10.16984/saufenbilder.742432
AMA Dilek Tepe H, Uğurlu A, Yazgan İ. Determination of Phenolic Compounds, Organic Volatile Molecules and Anti-Cancer Properties in Inula Viscosa L., Viscum Album L. and Raphanus Sativus L. SAUJS. June 2021;25(3):647-662. doi:10.16984/saufenbilder.742432
Chicago Dilek Tepe, Hafize, Aslı Uğurlu, and İdris Yazgan. “ And Raphanus Sativus L”. Sakarya University Journal of Science 25, no. 3 (June 2021): 647-62. https://doi.org/10.16984/saufenbilder.742432.
EndNote Dilek Tepe H, Uğurlu A, Yazgan İ (June 1, 2021) Determination of Phenolic Compounds, Organic Volatile Molecules and Anti-Cancer Properties in Inula Viscosa L., Viscum Album L. and Raphanus Sativus L. Sakarya University Journal of Science 25 3 647–662.
IEEE H. Dilek Tepe, A. Uğurlu, and İ. Yazgan, “ and Raphanus Sativus L”., SAUJS, vol. 25, no. 3, pp. 647–662, 2021, doi: 10.16984/saufenbilder.742432.
ISNAD Dilek Tepe, Hafize et al. “ And Raphanus Sativus L”. Sakarya University Journal of Science 25/3 (June 2021), 647-662. https://doi.org/10.16984/saufenbilder.742432.
JAMA Dilek Tepe H, Uğurlu A, Yazgan İ. Determination of Phenolic Compounds, Organic Volatile Molecules and Anti-Cancer Properties in Inula Viscosa L., Viscum Album L. and Raphanus Sativus L. SAUJS. 2021;25:647–662.
MLA Dilek Tepe, Hafize et al. “ And Raphanus Sativus L”. Sakarya University Journal of Science, vol. 25, no. 3, 2021, pp. 647-62, doi:10.16984/saufenbilder.742432.
Vancouver Dilek Tepe H, Uğurlu A, Yazgan İ. Determination of Phenolic Compounds, Organic Volatile Molecules and Anti-Cancer Properties in Inula Viscosa L., Viscum Album L. and Raphanus Sativus L. SAUJS. 2021;25(3):647-62.