The Effect of Royal Jelly on Irisin in Experimentally Diabetic Rats

Year 2023, Volume: 27 Issue: 4, 912 - 919, 25.08.2023

Selcen ÇAKIR

https://doi.org/10.16984/saufenbilder.1256089

Abstract

Diabetes Mellitus (DM) is considered a very common health problem today. It causes many acute and chronic complications and negatively affects the quality of life of patients. It is known that diabetes has an impact on many biochemical processes. This study aimed to evaluate the interaction between royal jelly (RJ) and diabetes with irisin, a parameter that has not been investigated before. The study was planned with 3 groups: control group, DM group, DM+350 mg/kg RJ group. In the experiments, 18 female Wistar albino rats were studied. Irisin levels in rat blood serum were determined using the ELISA (Enzyme-Linked Immuno Sorbent Assay) method. Glucose levels in blood taken from the tail vein were determined with a glucometer. As a result of the experimental study, a statistically significant difference was found in the DM+350 mg/kg RJ group compared to the control group (p<0.05). The selected dose reduced serum irisin levels in RJ applications. With diabetes, a statistically significant increase was observed in blood glucose levels (p<0.05). Although the RJ application caused a numerical decrease, it was not statistically significant. Previous studies have emphasized the effect of RJ on DM and blood biochemical parameters; however, the observation that the relevant dose of RJ reduces irisin levels is recent. The relationship of irisin with energy metabolism is still being investigated. Further studies are required to explain the relationship between irisin and RJ.

Keywords

Diabetes mellitus, Irisin, Royal jelly

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