SARS-CoV-2 Enfeksiyonu ve Bağırsak-Akciğer Aksı

Yonca Sevim; Özlem Persil Özkan

SARS-CoV-2 Enfeksiyonu ve Bağırsak-Akciğer Aksı

Öz

Koronavirüs hastalığı-2019 (COVID-19), 2019 yılının Aralık ayı sonunda Çin'in Wuhan kentinde ortaya çıkan ve şiddetli akut solunum sıkıntısı sendromu koronavirüs 2’nin (SARS-CoV-2) neden olduğu bulaşıcı bir hastalıktır. COVID-19'un solunum sıkıntısının yanı sıra ülseratif kolit ile birlikte gastrointestinal enfeksiyon ve diyare gibi diğer organları etkileyen bazı klasik olmayan semptomlarla ilişkili olduğu görülmüştür. Gastrointestinal enfeksiyon semptomları olan hastalar hastalığı çok daha şiddetli geçirmektedir ve bunun sebebinin Lactobacillus ve Bifidobacterium sayısındaki azalma ile birlikte ortaya çıkan mikrobiyal disbiyoz ile ilişkili olabileceği düşünülmektedir. SARS-CoV-2 virüsünün konak organizmaya girişi, anjiyotensin dönüştürücü enzim 2 (ACE-2) hücre reseptörü aracılığı ile gerçekleşmektedir ve ACE-2 reseptörleri gastrointestinal kanalda da eksprese edilmektedir. SARS-CoV-2 virüsü COVID-19 hastalarının özefagus, mide, duodenum, rektum ve dışkı örneklerinde tespit edilmiş, bağırsak epitel hücrelerinde viral replikasyonun yüksek olduğu gösterilmiştir. Gastarointestinal sistemin sadece SARS-CoV-2’nin vücuda giriş yolu olmadığı aynı zamanda viral aktivite ve replikasyon yeri olabileceği de düşünülmektedir. Bağırsak-akciğer aksı olarak bilinen, solunum mukozası ile bağırsak mikrobiyotası arasındaki çift yönlü etkileşimlerin, SARS-CoV-2'ye karşı sağlıklı veya patolojik bağışıklık tepkilerinde yer aldığı varsayılmaktadır. Bağırsak mikrobiyotasının modülasyonuna ve eubiosis koşullarının yeniden oluşturulmasına dayalı ek tedavilerin, COVID-19'un zararlı sonuçlarını sınırlamak için önemli bir terapötik yaklaşım olabileceği varsayılmaktadır. Bu derleme çalışmasında bağırsak akciğer ekseni ve SARS-CoV-2 virüsü enfeksiyonunda bu eksende değişen mikrobiyota ile ilgili çalışmaların sonuçları araştırılmıştır.

Anahtar Kelimeler

Destekleyen Kurum

Yok

Teşekkür

Yok

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Beslenme ve Diyetetik

Bölüm

Derleme

Yazarlar

Yonca Sevim ^*
0000-0003-2793-1318
Türkiye

Özlem Persil Özkan
0000-0003-2871-0090
Türkiye

Yayımlanma Tarihi

24 Aralık 2021

Gönderilme Tarihi

2 Kasım 2021

Kabul Tarihi

11 Kasım 2021

Yayımlandığı Sayı

Yıl 2021 Cilt: 5 Sayı: 1

IZ

https://izlik.org/JA73WM34RW

Kaynak Göster

RIS / Bibtex

APA

Sevim, Y., & Persil Özkan, Ö. (2021). SARS-CoV-2 Enfeksiyonu ve Bağırsak-Akciğer Aksı. Sağlık Bilimleri ve Yaşam Dergisi, 5(1), 26-36. https://izlik.org/JA73WM34RW

AMA

1.Sevim Y, Persil Özkan Ö. SARS-CoV-2 Enfeksiyonu ve Bağırsak-Akciğer Aksı. SBYD. 2021;5(1):26-36. https://izlik.org/JA73WM34RW

Chicago

Sevim, Yonca, ve Özlem Persil Özkan. 2021. “SARS-CoV-2 Enfeksiyonu ve Bağırsak-Akciğer Aksı”. Sağlık Bilimleri ve Yaşam Dergisi 5 (1): 26-36. https://izlik.org/JA73WM34RW.

EndNote

Sevim Y, Persil Özkan Ö (01 Aralık 2021) SARS-CoV-2 Enfeksiyonu ve Bağırsak-Akciğer Aksı. Sağlık Bilimleri ve Yaşam Dergisi 5 1 26–36.

IEEE

[1]Y. Sevim ve Ö. Persil Özkan, “SARS-CoV-2 Enfeksiyonu ve Bağırsak-Akciğer Aksı”, SBYD, c. 5, sy 1, ss. 26–36, Ara. 2021, [çevrimiçi]. Erişim adresi: https://izlik.org/JA73WM34RW

ISNAD

Sevim, Yonca - Persil Özkan, Özlem. “SARS-CoV-2 Enfeksiyonu ve Bağırsak-Akciğer Aksı”. Sağlık Bilimleri ve Yaşam Dergisi 5/1 (01 Aralık 2021): 26-36. https://izlik.org/JA73WM34RW.

JAMA

1.Sevim Y, Persil Özkan Ö. SARS-CoV-2 Enfeksiyonu ve Bağırsak-Akciğer Aksı. SBYD. 2021;5:26–36.

MLA

Sevim, Yonca, ve Özlem Persil Özkan. “SARS-CoV-2 Enfeksiyonu ve Bağırsak-Akciğer Aksı”. Sağlık Bilimleri ve Yaşam Dergisi, c. 5, sy 1, Aralık 2021, ss. 26-36, https://izlik.org/JA73WM34RW.

Vancouver

1.Yonca Sevim, Özlem Persil Özkan. SARS-CoV-2 Enfeksiyonu ve Bağırsak-Akciğer Aksı. SBYD [Internet]. 01 Aralık 2021;5(1):26-3. Erişim adresi: https://izlik.org/JA73WM34RW