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Effects of Food Based Yeast on Oxidant-Antioxidant Systems in Rats fed by High Cholesterol Diet

Year 2013, Volume 5, Issue 3, 252 - 255, 01.09.2013

Abstract

In living organisms, oxidant and antioxidant systems are in a balance. In the present study, our aim was to study the effects of Cryptococcus humicola, which is a food based yeast whose cholesterol lowering activity is under investigation, on oxidant and antioxidant systems.

31 adult male, Wistar albino rats weighing 200-250 gr were included in the study. Rats were divided into four groups based on their diets. Group 1(Control Group) was fed a normal diet, Group 2 was fed a high cholesterol diet, Group 3 was fed a high cholesterol and low dose yeast diet (0.1% lyophilysed yeast), and Group 4 was fed a high cholesterol and high dose yeast diet (2% lyophilysed yeast). After fifty six days, bloods were taken and serums were collected. Total antioxidant capacity (TAS) and total oxidant capacity (TOS) levels were determined through Erel method.

When TAS, TOS and OSI values were compared by nonparametric Kruskall Wallis test, no significant difference was found among the groups. 

This may lead to questioning the efficiency of the diet. It may be possible to show the antioxidant activity of c. humicola by increasing the yeast dose, number of subjects and duration of the experiment.

References

  • Amdekar S, Singh V, Kumar A, Sharma P, Singh R. 2013. Lactobacillus casei and Lactobacillus acidophilus regulate inflammatory pathway and improve antioxidant status in collagen-induced arthritic rats. J Interferon Cytokine Res. 33(1): 1-8.
  • Anwar H, Rahman ZU, Javed I, Muhammad F. 2012. Effect of protein, probiotic, and symbiotic supplementation on serum biological health markers of molted layers. Poult Sci 91(10): 2606-2613.
  • Awaisheh SS, Khalifeh MS, Al-Ruwaili MA, Khalil OM, Al-Ameri OH, Al-Groom R. 2013. Effect of supplementation of probiotics and phytosterols alone or in combination on serum and hepatic lipid profiles and thyroid hormones of hypercholesterolemic rats. J Dairy Sci. 96(1): 9-15.
  • Belet N. 2011. Çocuklarda Nadir Görülen İnvazif Mantar Enfeksiyonları. J Pediatr Inf 5 (Suppl 1), 183-187.
  • Benyacoub J, Rochat F, Saudan KY.2008. Feeding a diet containing a fructooligosaccharide mix can anhance Salmonella vacine efficacy in mice. J Nutr 138: 123-129
  • Bockelmann W, Heller M, Heller KJ. 2008. Identification of Yeasts of Dairy Origin by Amplified Ribosomal DNA Restriction Analysis (ARDRA), Int Dairy J. 18: 1066-1071.
  • Boehm G, Lidestri M, Casetta P. 2002. Supplementation of a bovine milk Formula with an oligosaccharide mixture increases counts of faecal bifidobacteria in preterm infants. Arch Dis Child Fetal Neonatal Ed 86: 78-81.
  • Bruzzese E, Volpicelli M, Salvini F. 2005. Early administration of GOS/ FOS prevents intestinal and respiratory infections in infants. J Pediatr Gastroenterol Nutr 40: 36-42
  • Erel O. (2004) A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem 37:277–285.
  • Esen E. 2008. Farklı Gıda Maddelerinde Maya Kontaminasyonu Üzerine Bir Çalışma (Yüksek Lisans Tezi). İstanbul Üniversitesi Sağlık Bilimleri Ensitüsü. Besin Hijyeni ve Teknolojisi Anabilim Dalı. Istanbul. Turkey. Pp 15-22.
  • Giorgi PL. 2009. Probiotics a review. Recenti Prog Med. 100(1):40-47.
  • Halliwell B, Gutteridge JMC. 1984. Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J 219: 1-4
  • Hanie S. Ejtahed M. Javad Mohtadi-Nia, Aziz Homayouni-Rad. Mitra Niafar, Mohammad Asghari-Jafarabadi, Vahid Mofid, 2012. Probiotic yogurt improves antioxidant status in type 2 diabetic patients. Nutrition 28: 539–543
  • Havenaar R, Huis I’ntVeld MJH. 1992. Probiotics: a general view. In: Lactic acid bacteria in health and disease. Vol 2. Elsevier Applied Sciences Publishers. Amsterdam. Pp 8-15.
  • Isolauri E. 2004. The role of probiotics in pediatrics. Curr Pediatr 24: 104-109.
  • Kurtzman CP, Fell JW, Boekhout T. 2011. The yeasts a taxonomic study. Fifth Edition. Elsevier. London. pp 22-36.
  • Mahfouz MM, Kumerrow FA. 2000. Cholesterol-rich diets have different effects on lipid peroxidation, cholesterol oxides and antioxidant enzymes in rats and rabbits. J Nutr Biochem 11: 293-302.
  • Metehan Ö. 2011. Sağlıklı kalmak için probiyotikler, prebiyotikler anlatılmayan tarihçe. Nobel Tıp Kitapevleri. İstanbul. Türkiye. p1-11
  • Simova E, Beshkova D, Angelov A, Hristozova T.S., Frengova G, Spasov Z. 2002. Lactic Acid Bacteria and Yeasts in Kefir Grains and Kefir Made from Them. J Ind Microbiol Biotechnol 28: 1-6.
  • Vasile N, Ghindea R, Vassu T. 2011. Probiotics an alternative treatment for various diseases. Roum Arch Microbiol Immunol. 70(2): 54-59.
  • Zhang J, Harbottle G, Wang C, Kong Z. 1999. Oldest playable musical instruments found at Jiahuearly Neolithic site in China. Nature 401:366-8.

Year 2013, Volume 5, Issue 3, 252 - 255, 01.09.2013

Abstract

References

  • Amdekar S, Singh V, Kumar A, Sharma P, Singh R. 2013. Lactobacillus casei and Lactobacillus acidophilus regulate inflammatory pathway and improve antioxidant status in collagen-induced arthritic rats. J Interferon Cytokine Res. 33(1): 1-8.
  • Anwar H, Rahman ZU, Javed I, Muhammad F. 2012. Effect of protein, probiotic, and symbiotic supplementation on serum biological health markers of molted layers. Poult Sci 91(10): 2606-2613.
  • Awaisheh SS, Khalifeh MS, Al-Ruwaili MA, Khalil OM, Al-Ameri OH, Al-Groom R. 2013. Effect of supplementation of probiotics and phytosterols alone or in combination on serum and hepatic lipid profiles and thyroid hormones of hypercholesterolemic rats. J Dairy Sci. 96(1): 9-15.
  • Belet N. 2011. Çocuklarda Nadir Görülen İnvazif Mantar Enfeksiyonları. J Pediatr Inf 5 (Suppl 1), 183-187.
  • Benyacoub J, Rochat F, Saudan KY.2008. Feeding a diet containing a fructooligosaccharide mix can anhance Salmonella vacine efficacy in mice. J Nutr 138: 123-129
  • Bockelmann W, Heller M, Heller KJ. 2008. Identification of Yeasts of Dairy Origin by Amplified Ribosomal DNA Restriction Analysis (ARDRA), Int Dairy J. 18: 1066-1071.
  • Boehm G, Lidestri M, Casetta P. 2002. Supplementation of a bovine milk Formula with an oligosaccharide mixture increases counts of faecal bifidobacteria in preterm infants. Arch Dis Child Fetal Neonatal Ed 86: 78-81.
  • Bruzzese E, Volpicelli M, Salvini F. 2005. Early administration of GOS/ FOS prevents intestinal and respiratory infections in infants. J Pediatr Gastroenterol Nutr 40: 36-42
  • Erel O. (2004) A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem 37:277–285.
  • Esen E. 2008. Farklı Gıda Maddelerinde Maya Kontaminasyonu Üzerine Bir Çalışma (Yüksek Lisans Tezi). İstanbul Üniversitesi Sağlık Bilimleri Ensitüsü. Besin Hijyeni ve Teknolojisi Anabilim Dalı. Istanbul. Turkey. Pp 15-22.
  • Giorgi PL. 2009. Probiotics a review. Recenti Prog Med. 100(1):40-47.
  • Halliwell B, Gutteridge JMC. 1984. Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J 219: 1-4
  • Hanie S. Ejtahed M. Javad Mohtadi-Nia, Aziz Homayouni-Rad. Mitra Niafar, Mohammad Asghari-Jafarabadi, Vahid Mofid, 2012. Probiotic yogurt improves antioxidant status in type 2 diabetic patients. Nutrition 28: 539–543
  • Havenaar R, Huis I’ntVeld MJH. 1992. Probiotics: a general view. In: Lactic acid bacteria in health and disease. Vol 2. Elsevier Applied Sciences Publishers. Amsterdam. Pp 8-15.
  • Isolauri E. 2004. The role of probiotics in pediatrics. Curr Pediatr 24: 104-109.
  • Kurtzman CP, Fell JW, Boekhout T. 2011. The yeasts a taxonomic study. Fifth Edition. Elsevier. London. pp 22-36.
  • Mahfouz MM, Kumerrow FA. 2000. Cholesterol-rich diets have different effects on lipid peroxidation, cholesterol oxides and antioxidant enzymes in rats and rabbits. J Nutr Biochem 11: 293-302.
  • Metehan Ö. 2011. Sağlıklı kalmak için probiyotikler, prebiyotikler anlatılmayan tarihçe. Nobel Tıp Kitapevleri. İstanbul. Türkiye. p1-11
  • Simova E, Beshkova D, Angelov A, Hristozova T.S., Frengova G, Spasov Z. 2002. Lactic Acid Bacteria and Yeasts in Kefir Grains and Kefir Made from Them. J Ind Microbiol Biotechnol 28: 1-6.
  • Vasile N, Ghindea R, Vassu T. 2011. Probiotics an alternative treatment for various diseases. Roum Arch Microbiol Immunol. 70(2): 54-59.
  • Zhang J, Harbottle G, Wang C, Kong Z. 1999. Oldest playable musical instruments found at Jiahuearly Neolithic site in China. Nature 401:366-8.

Details

Subjects Science
Journal Section Original Articles
Authors

Hasan Basri Savaş This is me


Özlem Yüksel This is me


Hatice Şanlıdere Aloğlu
0000-0001-6004-0694


Zübeyde Öner
0000-0003-2557-0731


Ezgi Demir Özer This is me


Fatih Gültekin

Publication Date September 1, 2013
Published in Issue Year 2013, Volume 5, Issue 3

Cite

Bibtex @ { sducmfrr241670, journal = {Cell Membranes and Free Radical Research}, issn = {1308-416X}, address = {}, publisher = {Hücresel Sinir Bilimleri ve Oksidatif Stres Derneği}, year = {2013}, volume = {5}, pages = {252 - 255}, doi = {}, title = {Effects of Food Based Yeast on Oxidant-Antioxidant Systems in Rats fed by High Cholesterol Diet}, key = {cite}, author = {Savaş, Hasan Basri and Yüksel, Özlem and Şanlıdere Aloğlu, Hatice and Öner, Zübeyde and Demir Özer, Ezgi and Gültekin, Fatih} }
APA Savaş, H. B. , Yüksel, Ö. , Şanlıdere Aloğlu, H. , Öner, Z. , Demir Özer, E. & Gültekin, F. (2013). Effects of Food Based Yeast on Oxidant-Antioxidant Systems in Rats fed by High Cholesterol Diet . Cell Membranes and Free Radical Research , 5 (3) , 252-255 . Retrieved from https://dergipark.org.tr/en/pub/sducmfrr/issue/22608/241670
MLA Savaş, H. B. , Yüksel, Ö. , Şanlıdere Aloğlu, H. , Öner, Z. , Demir Özer, E. , Gültekin, F. "Effects of Food Based Yeast on Oxidant-Antioxidant Systems in Rats fed by High Cholesterol Diet" . Cell Membranes and Free Radical Research 5 (2013 ): 252-255 <https://dergipark.org.tr/en/pub/sducmfrr/issue/22608/241670>
Chicago Savaş, H. B. , Yüksel, Ö. , Şanlıdere Aloğlu, H. , Öner, Z. , Demir Özer, E. , Gültekin, F. "Effects of Food Based Yeast on Oxidant-Antioxidant Systems in Rats fed by High Cholesterol Diet". Cell Membranes and Free Radical Research 5 (2013 ): 252-255
RIS TY - JOUR T1 - Effects of Food Based Yeast on Oxidant-Antioxidant Systems in Rats fed by High Cholesterol Diet AU - Hasan Basri Savaş , Özlem Yüksel , Hatice Şanlıdere Aloğlu , Zübeyde Öner , Ezgi Demir Özer , Fatih Gültekin Y1 - 2013 PY - 2013 N1 - DO - T2 - Cell Membranes and Free Radical Research JF - Journal JO - JOR SP - 252 EP - 255 VL - 5 IS - 3 SN - 1308-416X- M3 - UR - Y2 - 2021 ER -
EndNote %0 Cell Membranes and Free Radical Research Effects of Food Based Yeast on Oxidant-Antioxidant Systems in Rats fed by High Cholesterol Diet %A Hasan Basri Savaş , Özlem Yüksel , Hatice Şanlıdere Aloğlu , Zübeyde Öner , Ezgi Demir Özer , Fatih Gültekin %T Effects of Food Based Yeast on Oxidant-Antioxidant Systems in Rats fed by High Cholesterol Diet %D 2013 %J Cell Membranes and Free Radical Research %P 1308-416X- %V 5 %N 3 %R %U
ISNAD Savaş, Hasan Basri , Yüksel, Özlem , Şanlıdere Aloğlu, Hatice , Öner, Zübeyde , Demir Özer, Ezgi , Gültekin, Fatih . "Effects of Food Based Yeast on Oxidant-Antioxidant Systems in Rats fed by High Cholesterol Diet". Cell Membranes and Free Radical Research 5 / 3 (September 2013): 252-255 .
AMA Savaş H. B. , Yüksel Ö. , Şanlıdere Aloğlu H. , Öner Z. , Demir Özer E. , Gültekin F. Effects of Food Based Yeast on Oxidant-Antioxidant Systems in Rats fed by High Cholesterol Diet. Cell Membranes and Free Radical Research. 2013; 5(3): 252-255.
Vancouver Savaş H. B. , Yüksel Ö. , Şanlıdere Aloğlu H. , Öner Z. , Demir Özer E. , Gültekin F. Effects of Food Based Yeast on Oxidant-Antioxidant Systems in Rats fed by High Cholesterol Diet. Cell Membranes and Free Radical Research. 2013; 5(3): 252-255.
IEEE H. B. Savaş , Ö. Yüksel , H. Şanlıdere Aloğlu , Z. Öner , E. Demir Özer and F. Gültekin , "Effects of Food Based Yeast on Oxidant-Antioxidant Systems in Rats fed by High Cholesterol Diet", Cell Membranes and Free Radical Research, vol. 5, no. 3, pp. 252-255, Sep. 2013