DİYABETİK VE BENFLUOREKS-C VİTAMİNİ UYGULAMALI SIÇAN DERMİSİNDEKİ ELASTİK LİF VE FİBROBLAST DEĞİŞİMLERİNİN MİKROSKOBİK İNCELENMESİ

Seda Mehtap Sarı Kılıçaslan; Cevat Ayvalı; Bilge Gönül; Çiğdem Özer

doi:10.29233/sdufeffd.134661

DİYABETİK VE BENFLUOREKS-C VİTAMİNİ UYGULAMALI SIÇAN DERMİSİNDEKİ ELASTİK LİF VE FİBROBLAST DEĞİŞİMLERİNİN MİKROSKOBİK İNCELENMESİ

Abstract

Özet: Bu çalışma streptozotosin diyabetik ve benfluoreks–C vitamini tedavisi uygulanmış diyabetli derinin dermisindeki elastik lif ve fibroblastlarda meydana gelen değişimleri incelemektedir. Işık ve elektron mikroskobu incelemelerinde diyabet grubunda dermis kalınlaşması, elastik liflerde yoğunlaşmalar ve fibroblastlarda ise piknotik çekirdek ve dilate olmuş endoplazmik retikulumlar belirlenmiştir. Benfluoreks-C vitamini uygulamalı grupta ise diyabet grubunda gözlemlenen dejenerasyonlara rastlanmamış ve aktif fibroblastlar gözlenmiştir. Bu bulgular diyabetik deride benfluoreks-C vitamini uygulamasının elastik lifler ve fibroblast üzerine olumlu etkisi olduğunu göstermektedir. Anahtar kelimeler: Diyabet, benfluoreks, C vitamini, dermis, elektron mikroskop A MICROSCOPIC STUDY OF THE CHANGES IN ELASTIC FIBRES AND FIBROBLASTS IN DERMIS OF DIABETIC AND BENFLUOREX-VITAMIN C TREATED RATS Abstract: This study analyses changes in elastic fibres and fibroblasts in dermis of diabetic and benfluorex-vitamin C treated diabetic rats. Light and electron microscopy examinations revealed thickening of dermis and elastic fibres, pyknotic nucleus and swelling of endoplasmic reticulum in fibroblasts in streptozotocin diabetic rats. Among Benfluorex-C treated group, no degeneration of elastic fibres and thickening of dermis were determined. Moreover, active fibroblasts were observed in the treated group. These findings indicate the positive effect of Benfluorex and vitamin-C use in treatment of diabetic dermis. Key words: Diabetes, benfluorex, vitamin C, dermis, electron microscope

Keywords

Diyabet, benfluoreks, C vitamini, dermis, elektron mikroskop

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Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Seda Mehtap Sarı Kılıçaslan This is me

Cevat Ayvalı This is me

Bilge Gönül This is me

Çiğdem Özer This is me

Publication Date

June 8, 2009

Submission Date

June 8, 2009

Acceptance Date

-

Published in Issue

Year 2009 Volume: 4 Number: 1

DOI

https://doi.org/10.29233/sdufeffd.134661

IZ

https://izlik.org/JA72GS62KL

Cite

RIS / Bibtex

APA

Sarı Kılıçaslan, S. M., Ayvalı, C., Gönül, B., & Özer, Ç. (2009). DİYABETİK VE BENFLUOREKS-C VİTAMİNİ UYGULAMALI SIÇAN DERMİSİNDEKİ ELASTİK LİF VE FİBROBLAST DEĞİŞİMLERİNİN MİKROSKOBİK İNCELENMESİ. Süleyman Demirel University Faculty of Arts and Science Journal of Science, 4(1), 12-22. https://doi.org/10.29233/sdufeffd.134661

AMA

1.Sarı Kılıçaslan SM, Ayvalı C, Gönül B, Özer Ç. DİYABETİK VE BENFLUOREKS-C VİTAMİNİ UYGULAMALI SIÇAN DERMİSİNDEKİ ELASTİK LİF VE FİBROBLAST DEĞİŞİMLERİNİN MİKROSKOBİK İNCELENMESİ. Süleyman Demirel University Faculty of Arts and Science Journal of Science. 2009;4(1):12-22. doi:10.29233/sdufeffd.134661

Chicago

Sarı Kılıçaslan, Seda Mehtap, Cevat Ayvalı, Bilge Gönül, and Çiğdem Özer. 2009. “DİYABETİK VE BENFLUOREKS-C VİTAMİNİ UYGULAMALI SIÇAN DERMİSİNDEKİ ELASTİK LİF VE FİBROBLAST DEĞİŞİMLERİNİN MİKROSKOBİK İNCELENMESİ”. Süleyman Demirel University Faculty of Arts and Science Journal of Science 4 (1): 12-22. https://doi.org/10.29233/sdufeffd.134661.

EndNote

Sarı Kılıçaslan SM, Ayvalı C, Gönül B, Özer Ç (June 1, 2009) DİYABETİK VE BENFLUOREKS-C VİTAMİNİ UYGULAMALI SIÇAN DERMİSİNDEKİ ELASTİK LİF VE FİBROBLAST DEĞİŞİMLERİNİN MİKROSKOBİK İNCELENMESİ. Süleyman Demirel University Faculty of Arts and Science Journal of Science 4 1 12–22.

IEEE

[1]S. M. Sarı Kılıçaslan, C. Ayvalı, B. Gönül, and Ç. Özer, “DİYABETİK VE BENFLUOREKS-C VİTAMİNİ UYGULAMALI SIÇAN DERMİSİNDEKİ ELASTİK LİF VE FİBROBLAST DEĞİŞİMLERİNİN MİKROSKOBİK İNCELENMESİ”, Süleyman Demirel University Faculty of Arts and Science Journal of Science, vol. 4, no. 1, pp. 12–22, June 2009, doi: 10.29233/sdufeffd.134661.

ISNAD

Sarı Kılıçaslan, Seda Mehtap - Ayvalı, Cevat - Gönül, Bilge - Özer, Çiğdem. “DİYABETİK VE BENFLUOREKS-C VİTAMİNİ UYGULAMALI SIÇAN DERMİSİNDEKİ ELASTİK LİF VE FİBROBLAST DEĞİŞİMLERİNİN MİKROSKOBİK İNCELENMESİ”. Süleyman Demirel University Faculty of Arts and Science Journal of Science 4/1 (June 1, 2009): 12-22. https://doi.org/10.29233/sdufeffd.134661.

JAMA

1.Sarı Kılıçaslan SM, Ayvalı C, Gönül B, Özer Ç. DİYABETİK VE BENFLUOREKS-C VİTAMİNİ UYGULAMALI SIÇAN DERMİSİNDEKİ ELASTİK LİF VE FİBROBLAST DEĞİŞİMLERİNİN MİKROSKOBİK İNCELENMESİ. Süleyman Demirel University Faculty of Arts and Science Journal of Science. 2009;4:12–22.

MLA

Sarı Kılıçaslan, Seda Mehtap, et al. “DİYABETİK VE BENFLUOREKS-C VİTAMİNİ UYGULAMALI SIÇAN DERMİSİNDEKİ ELASTİK LİF VE FİBROBLAST DEĞİŞİMLERİNİN MİKROSKOBİK İNCELENMESİ”. Süleyman Demirel University Faculty of Arts and Science Journal of Science, vol. 4, no. 1, June 2009, pp. 12-22, doi:10.29233/sdufeffd.134661.

Vancouver

1.Seda Mehtap Sarı Kılıçaslan, Cevat Ayvalı, Bilge Gönül, Çiğdem Özer. DİYABETİK VE BENFLUOREKS-C VİTAMİNİ UYGULAMALI SIÇAN DERMİSİNDEKİ ELASTİK LİF VE FİBROBLAST DEĞİŞİMLERİNİN MİKROSKOBİK İNCELENMESİ. Süleyman Demirel University Faculty of Arts and Science Journal of Science. 2009 Jun. 1;4(1):12-2. doi:10.29233/sdufeffd.134661