Effects of Trans-Cinnamaldehyde on Epithelial-Mesenchymal Markers in Prostate Cancer

Mehmet Balaban; Zeynep Akpınar; Nilgün Gürbüz

doi:10.29233/sdufeffd.1790466

Effects of Trans-Cinnamaldehyde on Epithelial-Mesenchymal Markers in Prostate Cancer

Abstract

Advanced-stage prostate cancer is associated with low survival rates and high metastatic potential, often driven by epithelial–mesenchymal transition (EMT). Current therapeutic options remain limited, encouraging the exploration of natural compounds with anticancer potential. Cinnamaldehyde (CA), a bioactive compound derived from Cinnamomum bark, was investigated for its effects on EMT markers in LNCaP prostate cancer cells. Cells were treated with 10–40 µM CA for 24 and 48 hours, and cell viability was assessed using the MTT assay to identify effective concentrations. Expression levels of EMT-related genes such as E-cadherin, Claudin, ZEB-1, Vimentin and MMP-2 were analyzed via RT-PCR. CA reduced prostate cancer cell viability at 20–30 µM and modulated EMT, as evidenced by decreased mesenchymal markers (ZEB-1, MMP-2, Vimentin) and increased epithelial markers (E-cadherin, Claudin). These results underscore its therapeutic potential, warranting further in vivo and clinical investigations to fully assess efficacy and safety.

Keywords

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Details

Primary Language

English

Subjects

Cell Development, Proliferation and Death, Gene Expression

Journal Section

Research Article

Authors

Mehmet Balaban
0009-0006-3701-984X
Türkiye

Zeynep Akpınar
0000-0001-9547-3967
Türkiye

Nilgün Gürbüz ^*
0000-0003-4476-5593
Türkiye

Publication Date

May 28, 2026

Submission Date

September 24, 2025

Acceptance Date

May 11, 2026

Published in Issue

Year 2026 Volume: 21 Number: 1

DOI

https://doi.org/10.29233/sdufeffd.1790466

IZ

https://izlik.org/JA64UY48WZ

Cite

RIS / Bibtex

APA

Balaban, M., Akpınar, Z., & Gürbüz, N. (2026). Effects of Trans-Cinnamaldehyde on Epithelial-Mesenchymal Markers in Prostate Cancer. Süleyman Demirel University Faculty of Arts and Science Journal of Science, 21(1), 92-103. https://doi.org/10.29233/sdufeffd.1790466

AMA

1.Balaban M, Akpınar Z, Gürbüz N. Effects of Trans-Cinnamaldehyde on Epithelial-Mesenchymal Markers in Prostate Cancer. Süleyman Demirel University Faculty of Arts and Science Journal of Science. 2026;21(1):92-103. doi:10.29233/sdufeffd.1790466

Chicago

Balaban, Mehmet, Zeynep Akpınar, and Nilgün Gürbüz. 2026. “Effects of Trans-Cinnamaldehyde on Epithelial-Mesenchymal Markers in Prostate Cancer”. Süleyman Demirel University Faculty of Arts and Science Journal of Science 21 (1): 92-103. https://doi.org/10.29233/sdufeffd.1790466.

EndNote

Balaban M, Akpınar Z, Gürbüz N (May 1, 2026) Effects of Trans-Cinnamaldehyde on Epithelial-Mesenchymal Markers in Prostate Cancer. Süleyman Demirel University Faculty of Arts and Science Journal of Science 21 1 92–103.

IEEE

[1]M. Balaban, Z. Akpınar, and N. Gürbüz, “Effects of Trans-Cinnamaldehyde on Epithelial-Mesenchymal Markers in Prostate Cancer”, Süleyman Demirel University Faculty of Arts and Science Journal of Science, vol. 21, no. 1, pp. 92–103, May 2026, doi: 10.29233/sdufeffd.1790466.

ISNAD

Balaban, Mehmet - Akpınar, Zeynep - Gürbüz, Nilgün. “Effects of Trans-Cinnamaldehyde on Epithelial-Mesenchymal Markers in Prostate Cancer”. Süleyman Demirel University Faculty of Arts and Science Journal of Science 21/1 (May 1, 2026): 92-103. https://doi.org/10.29233/sdufeffd.1790466.

JAMA

1.Balaban M, Akpınar Z, Gürbüz N. Effects of Trans-Cinnamaldehyde on Epithelial-Mesenchymal Markers in Prostate Cancer. Süleyman Demirel University Faculty of Arts and Science Journal of Science. 2026;21:92–103.

MLA

Balaban, Mehmet, et al. “Effects of Trans-Cinnamaldehyde on Epithelial-Mesenchymal Markers in Prostate Cancer”. Süleyman Demirel University Faculty of Arts and Science Journal of Science, vol. 21, no. 1, May 2026, pp. 92-103, doi:10.29233/sdufeffd.1790466.

Vancouver

1.Mehmet Balaban, Zeynep Akpınar, Nilgün Gürbüz. Effects of Trans-Cinnamaldehyde on Epithelial-Mesenchymal Markers in Prostate Cancer. Süleyman Demirel University Faculty of Arts and Science Journal of Science. 2026 May 1;21(1):92-103. doi:10.29233/sdufeffd.1790466