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Investigation of Gamma Irradiated Carvedilol Drug by EPR Technique at 295 Kelvin

Year 2018, , 83 - 89, 30.11.2018
https://doi.org/10.29233/sdufeffd.453762

Abstract

This study aims to investigate free radicals produced after gamma irradiation of
carvedilol, the drug used in the treatment of cardiovascular, at 295 Kelvin. While unirradiated
powder samples of carvedilol do not exhibit any EPR signal, irradiated samples exhibited a
sharp and clear EPR signal. After the irradiation of the samples with gamma rays, EPR signal
intensities were increased significantly based on the irradiation dose. Mathematical functions
and correlation coefficients were calculated determining the relation between the increasing
radiation doses on the signal intensities of the sample. The results were found to be in good
agreement with the existing literature data.

References

  • J. Raffi, S. Gelly, L. Barral, F. Burger, P. Piccerelle, P. Prinderre P, and A. Chamayou, “Electron paramagnetic resonance of radicals induced in drugs and excipients by radiation or mechanical treatments,” Spectrochim. Acta Part A, vol. 58, pp.1313-1320, 2002.
  • H. Murrieta, E. Munoz, E. Adem, G. Burillo, M. Vazquez, and E. Cabrera, “Effect of irradiation dose, storage time and temperature on the ESR signal in irradiated oat, corn and wheat,” Radiat. Isot. Vol. 47, pp. 1657-1661,1996.
  • K. Sütçü,Y.E. Osmanoğlu and F. Akbalık, “ Investigation of radiosensitivity of gamma irradiated isoniazid antibiotic through EPR spectroscopy,” Anadolu University J. Scien.Tech. vol.17, pp.753-740, 2016.
  • Ş. Çolak, A. Maquille, and Tilquin B, “Chemical analysis applied to the radiation sterilization of solid ketoprofen,” Radiat. Eff. Defects Solids vol. 161, pp. 75-80, 2006.
  • Ş.Osmanoğlu, “Electron paramagnetic resonance of radiation damage of γ-irradiated diethylmalonic acid,” J. Mol. Struct. Vol. 877, pp.7-9, 2008.
  • Ş. Osmanoğlu, F. Köksal, I, Kartal, and F. Ucun, “Electron paramagnetic resonance of gamma-irradiated single crystals of two isobutyric acid derivatives,” Radiat. Phys. Chem. Vol.49, pp. 419-420, 1997.
  • K. Sütçü, and Y.E. Osmanoğlu, “The effect of gamma radiation on some succinic acid derivatives in the solid state,” J. Mol. Struct. vol. 1127, pp. 476-478, 2017.
  • Y.E. Osmanoğlu, A.Tokatlı , K. Sütçü, Ş. Osmanoğlu, and F. Ucun, “ Conformational, IR, NMR, and EPR analysis of ifosfamide by density functional theory calculation” Monatshefte für Chemie vol. 1154, pp. 428-436, 2017.
  • B.K. Singh, D.V. Parwate, I.B. Dassarma, and S.K. Shukla, “Investigation of effect of gamma radiation and electron beam,” Appl. Radiat. Isot. Vol.68, pp. 1627-1635, 2010.
  • J.P. Basly, I. Longy, and M. Bernard, “Radiosterilization dosimetry by electron-spin resonance spectroscopy: Cefotetan,” Anal. Chim. Acta vol. 359, pp. 107-113, 1998.
  • H.B. Ambroż , E.M. Kornacka, B. Marciniec, M. Ogrodowczyk,and G.K. Przybytniak, “EPR study of free radicals in some drugs γ-irradiated in the solid state,” Radiat. Phys. Chem.vol. 58, pp. 357-366, 2000.
  • G. Damian, and V. Miclăuş, “Study of free radicals in gamma-irradiated metoclopramide using spin trapping ESR spectroscopy,” Rom. J. Biophys. Vol. 15, pp. 121-126, 2005.
  • A.Lund, S. Olsson, M. Bonora, E. Lund, and H.Gustafsson, “New materials for ESR dosimetry.” Spectrochim Acta A vol. 58, pp. 1301-1311,2002.
  • M. Ikeya, M. Hassan, H. Sasaoka,Y. Kinoshita, S.Takaki, and C. Yamanaka, “Strategy for finding new materials for ESR dosimeters,” Appl.Radiat.Isot. vol. 52, pp. 1209-1215, 2000.
  • G. Damian, “ EPR investigation of γ-irradiated anti-emetic drugs,” Talanta, vol. 60, pp. 923-927, 2003.
  • K. Amirshahrokhi , and A.R. Khalili, “Carvedilol attenuates paraquat-induced lung injury by inhibition of proinflammatory cytokines, chemokine MCP-1, NF-κB activation and oxidative stress mediators. “ Cytokine , vol. 88: pp. 144-153, 2002.
  • Z. Li, B. Liu, B. Wang, Y. Liu, Y. Zhang, F. Tian, and D. Zhao. “Carvedilol suppresses cartilage matrix destruction”. Biochem. Biophys. Res. Com. Vol. 480, pp. 309-313, 2016.
  • H. Ambroż , E. Kornacka, B. Marciniec, G.J. Przybytniak . “.”Radical decay in irradiated drugs: Flutamide, ifosfamide,” Radioanal. Nuc. Chem. vol. 254, pp. 293-298, 2002.
  • R. Köseoǧlu, E. Köseoǧlu, and F. Köksal. “Electron paramagnetic resonance of some γ-irradiated drugs.”Appl. Radiat. Isot. vol.58, pp. 63-68, 2003.
  • M. Aydın, Y.E. Osmanoglu, and Başkan MH. “Electron paramagnetic resonance of γ-irradiated glycyl-l-glutamine monohydrate, iminodiacetic acid and methyliminodiacetic acid.” Radiat. Eff. Defects Solids vol. 163, pp. 47-53, 2008.
  • M.F. Desrosiers, “Estimation of the absorbed dose in radiation-processed food—2. Test of the EPR response function by an exponential fitting analysis.” Int. J. Radiat. Appl. Instr. Part A vol. 42, pp. 617-619, 1991.
  • A.A. Abdel-Fattah, “Identification and dose assessment of irradiated cumin by EPR spectrometry” Appl. Radiat. Isot. vol. 56, pp. 557-562, 2002.

Gama ile Işınlanmış Karvedilol İlacının EPR Tekniği ile 295 Kelvinde İncelenmesi

Year 2018, , 83 - 89, 30.11.2018
https://doi.org/10.29233/sdufeffd.453762

Abstract

Bu çalışmada kardiovasküler tedavisinde kullanılan karvedilol ilacının gama ile
ışınlanmasının ardından yapısında oluşan serbest radikaller 295 Kelvin sıcaklıkta incelendi.
Işınlanmamış toz halindeki karvedilol örneğinde herhangi bir EPR sinyali gözlenmezken,
ışınlanmış örneklerin belirgin sinyaller sergiledikleri gözlendi. Işınlanmış örneklerde, ışınlama
dozuna bağlı olarak EPR sinyallerinin belirgin artışı gerçekleşti. Örneğin artan radyasyon
dozuna bağlı sinyal şiddetindeki artışı tanımlayan matematiksel denklemler ve korelasyon
katsayıları hesaplandı. Sonuçların mevcut literatür verileri ile uyum içinde olduğu tespit edildi.

References

  • J. Raffi, S. Gelly, L. Barral, F. Burger, P. Piccerelle, P. Prinderre P, and A. Chamayou, “Electron paramagnetic resonance of radicals induced in drugs and excipients by radiation or mechanical treatments,” Spectrochim. Acta Part A, vol. 58, pp.1313-1320, 2002.
  • H. Murrieta, E. Munoz, E. Adem, G. Burillo, M. Vazquez, and E. Cabrera, “Effect of irradiation dose, storage time and temperature on the ESR signal in irradiated oat, corn and wheat,” Radiat. Isot. Vol. 47, pp. 1657-1661,1996.
  • K. Sütçü,Y.E. Osmanoğlu and F. Akbalık, “ Investigation of radiosensitivity of gamma irradiated isoniazid antibiotic through EPR spectroscopy,” Anadolu University J. Scien.Tech. vol.17, pp.753-740, 2016.
  • Ş. Çolak, A. Maquille, and Tilquin B, “Chemical analysis applied to the radiation sterilization of solid ketoprofen,” Radiat. Eff. Defects Solids vol. 161, pp. 75-80, 2006.
  • Ş.Osmanoğlu, “Electron paramagnetic resonance of radiation damage of γ-irradiated diethylmalonic acid,” J. Mol. Struct. Vol. 877, pp.7-9, 2008.
  • Ş. Osmanoğlu, F. Köksal, I, Kartal, and F. Ucun, “Electron paramagnetic resonance of gamma-irradiated single crystals of two isobutyric acid derivatives,” Radiat. Phys. Chem. Vol.49, pp. 419-420, 1997.
  • K. Sütçü, and Y.E. Osmanoğlu, “The effect of gamma radiation on some succinic acid derivatives in the solid state,” J. Mol. Struct. vol. 1127, pp. 476-478, 2017.
  • Y.E. Osmanoğlu, A.Tokatlı , K. Sütçü, Ş. Osmanoğlu, and F. Ucun, “ Conformational, IR, NMR, and EPR analysis of ifosfamide by density functional theory calculation” Monatshefte für Chemie vol. 1154, pp. 428-436, 2017.
  • B.K. Singh, D.V. Parwate, I.B. Dassarma, and S.K. Shukla, “Investigation of effect of gamma radiation and electron beam,” Appl. Radiat. Isot. Vol.68, pp. 1627-1635, 2010.
  • J.P. Basly, I. Longy, and M. Bernard, “Radiosterilization dosimetry by electron-spin resonance spectroscopy: Cefotetan,” Anal. Chim. Acta vol. 359, pp. 107-113, 1998.
  • H.B. Ambroż , E.M. Kornacka, B. Marciniec, M. Ogrodowczyk,and G.K. Przybytniak, “EPR study of free radicals in some drugs γ-irradiated in the solid state,” Radiat. Phys. Chem.vol. 58, pp. 357-366, 2000.
  • G. Damian, and V. Miclăuş, “Study of free radicals in gamma-irradiated metoclopramide using spin trapping ESR spectroscopy,” Rom. J. Biophys. Vol. 15, pp. 121-126, 2005.
  • A.Lund, S. Olsson, M. Bonora, E. Lund, and H.Gustafsson, “New materials for ESR dosimetry.” Spectrochim Acta A vol. 58, pp. 1301-1311,2002.
  • M. Ikeya, M. Hassan, H. Sasaoka,Y. Kinoshita, S.Takaki, and C. Yamanaka, “Strategy for finding new materials for ESR dosimeters,” Appl.Radiat.Isot. vol. 52, pp. 1209-1215, 2000.
  • G. Damian, “ EPR investigation of γ-irradiated anti-emetic drugs,” Talanta, vol. 60, pp. 923-927, 2003.
  • K. Amirshahrokhi , and A.R. Khalili, “Carvedilol attenuates paraquat-induced lung injury by inhibition of proinflammatory cytokines, chemokine MCP-1, NF-κB activation and oxidative stress mediators. “ Cytokine , vol. 88: pp. 144-153, 2002.
  • Z. Li, B. Liu, B. Wang, Y. Liu, Y. Zhang, F. Tian, and D. Zhao. “Carvedilol suppresses cartilage matrix destruction”. Biochem. Biophys. Res. Com. Vol. 480, pp. 309-313, 2016.
  • H. Ambroż , E. Kornacka, B. Marciniec, G.J. Przybytniak . “.”Radical decay in irradiated drugs: Flutamide, ifosfamide,” Radioanal. Nuc. Chem. vol. 254, pp. 293-298, 2002.
  • R. Köseoǧlu, E. Köseoǧlu, and F. Köksal. “Electron paramagnetic resonance of some γ-irradiated drugs.”Appl. Radiat. Isot. vol.58, pp. 63-68, 2003.
  • M. Aydın, Y.E. Osmanoglu, and Başkan MH. “Electron paramagnetic resonance of γ-irradiated glycyl-l-glutamine monohydrate, iminodiacetic acid and methyliminodiacetic acid.” Radiat. Eff. Defects Solids vol. 163, pp. 47-53, 2008.
  • M.F. Desrosiers, “Estimation of the absorbed dose in radiation-processed food—2. Test of the EPR response function by an exponential fitting analysis.” Int. J. Radiat. Appl. Instr. Part A vol. 42, pp. 617-619, 1991.
  • A.A. Abdel-Fattah, “Identification and dose assessment of irradiated cumin by EPR spectrometry” Appl. Radiat. Isot. vol. 56, pp. 557-562, 2002.
There are 22 citations in total.

Details

Primary Language Turkish
Subjects Metrology, Applied and Industrial Physics
Journal Section Makaleler
Authors

Yunus Emre Osmanoğlu 0000-0001-7338-7603

Publication Date November 30, 2018
Published in Issue Year 2018

Cite

IEEE Y. E. Osmanoğlu, “Gama ile Işınlanmış Karvedilol İlacının EPR Tekniği ile 295 Kelvinde İncelenmesi”, Süleyman Demirel University Faculty of Arts and Science Journal of Science, vol. 13, no. 2, pp. 83–89, 2018, doi: 10.29233/sdufeffd.453762.