Investigation of Gamma Irradiated Carvedilol Drug by EPR Technique at 295 Kelvin

Abstract

This study aims to investigate free radicals produced after gamma irradiation of carvedilol, the drug used in the treatment of cardiovascular, at 295 Kelvin. While unirradiated powder samples of carvedilol do not exhibit any EPR signal, irradiated samples exhibited a sharp and clear EPR signal. After the irradiation of the samples with gamma rays, EPR signal intensities were increased significantly based on the irradiation dose. Mathematical functions and correlation coefficients were calculated determining the relation between the increasing radiation doses on the signal intensities of the sample. The results were found to be in good agreement with the existing literature data.

Keywords

• Electron paramagnetic resonance,Free radicals,Gamma irradiation

Gama ile Işınlanmış Karvedilol İlacının EPR Tekniği ile 295 Kelvinde İncelenmesi

Abstract

Bu çalışmada kardiovasküler tedavisinde kullanılan karvedilol ilacının gama ile ışınlanmasının ardından yapısında oluşan serbest radikaller 295 Kelvin sıcaklıkta incelendi. Işınlanmamış toz halindeki karvedilol örneğinde herhangi bir EPR sinyali gözlenmezken, ışınlanmış örneklerin belirgin sinyaller sergiledikleri gözlendi. Işınlanmış örneklerde, ışınlama dozuna bağlı olarak EPR sinyallerinin belirgin artışı gerçekleşti. Örneğin artan radyasyon dozuna bağlı sinyal şiddetindeki artışı tanımlayan matematiksel denklemler ve korelasyon katsayıları hesaplandı. Sonuçların mevcut literatür verileri ile uyum içinde olduğu tespit edildi.

Keywords

• Elektron paramanyetik rezonans,Serbest radikal,Gama ışınlama

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