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Tıbbi125I Radyonüklidininα, d ve γ Girişli Reaksiyonlar Kullanılarak Üretim Tesir Kesitlerinin Hesaplanması

Year 2015, Volume: 10 Issue: 2, 116 - 121, 22.11.2015

Abstract

Özellikle 125I olmak üzere, iyot radyoizotopları tıpta kullanılan en önemli izotoplardır. 125I, prostat kanseri ve beyin tümörlerini tedavi etmek için radyasyon tedavisinde brakterapi kaynağı olarak kullanılır. Bu çalışmada, 40 MeV'e kadar farklı gelme enerjilerinde 23Sb (α,2n)125I, 124Te(d,n)125I, ve 127 I(γ,2n)125I reaksiyonları ile 125I radyonüklidin üretim tesir kesiti hesaplamaları araştırılmıştır. TALYS 1.6 İki Bileşenli Eksiton ve Genelleştirilmiş Süperakışkan modelleri, EMPIRE 3.1 Eksiton ve Genelleştirilmiş Süperakışkan modelleri teorik hesaplamaları gerçekleştirmek için kullanılmıştır. Hesaplanan sonuçlar, Deneysel Nükleer Veri Kütüphanesi (EXFOR)'dan alınan deneysel sonuçlar ile karşılaştırılmıştır. 125I radyoizotopunun deneysel üretim tesir kesiti değerleri, deneysel zorluklardan dolayı üretilemiyorsa EMPIRE 3.1Eksiton ve Genelleştirilmiş Süperakışkan modelleri kullanılması önerilmiştir.

References

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  • Masucci G. L., Donath D., Tétreault-Laflamme A., Carrier J.F., Hervieux Y., Larouche R. X.,BaharyJ.P.,Taussky D., 2010. Comparison between high and low source activity seeds for I-125 permanent seed prostate brachytherapy, International Journal of Radiation Oncology Biology Physics, 78 (3): 781–786.
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  • Herman M., Capote R., Carlson B. V., Obložinský P., Sin M., Trkov A.,Wienke H.,Zerkin, V., 2007. EMPIRE: Nuclear reaction model code system for data evaluation, Nuclear Data Sheets, 108 (12): 2655–2715.
  • Cline C.K., 1972. The Pauli exclusion principle in pre-equilibrium decay, Nuclear Physics A, 195: 353-360.
  • I. Ribansky et al., 1973, Pre-equilibrium decay and the exciton model, Nuclear Physics A, 205:545-560.
  • Herman M., Capote R., Sin M., Trkov A., 2012.EMPIRE–3.1 Rivoli modular system for nuclear reaction calculations and nuclear data evaluation. User's Manual.
  • Brookhaven National Laboratory, National Nuclear Data Center, EXFOR/CSISRS (Experimental Nuclear Reaction Data File). Database Version of August 20, 2014 (http://www.nndc.bnl.gov/exfor/) (2014)
  • Veli Çapalı e-mail: velicapali@gmail.com
  • İsmail Hakkı Sarpün e-mail: isarpun@aku.edu.tr
  • Abdullah Kaplan e-mail: abdullahkaplan@sdu.edu.tr

Production Cross–Section Calculations of Medical125I Radionuclide Using α, d and γ Induced Reactions

Year 2015, Volume: 10 Issue: 2, 116 - 121, 22.11.2015

Abstract

Iodine radioisotopes are the most important radioisotopes used in the medicine, especially 125I. 125I is used in radiation therapy as brachytherapy source to treat prostate cancer and brain tumors. In this study, production cross–section calculations of 125Iradionuclide used in medicine produced by 123Sb (α,2n)125I, 124Te(d,n)125I, and 127 I(γ,2n)125I reactions have been investigated in the different incident energy range up to 40 MeV. Two–Component Exciton and Generalized Superfluid models of the TALYS 1.6 code and Exciton and Generalized Superfluid models of the EMPIRE 3.1 code have been used to perform calculations. The calculated results have been compared with the experimental results taken fromthe Experimental Nuclear Reaction Data Library (EXFOR). EMPIRE 3.1 Exciton and Generalized Superfluid models are recommended, if experimental production cross–section of 125Iradionuclide data are not available to produce because of the experimental difficulties

References

  • Marchesi V., Gautier M., Villani N., Feuillade J.,Dejean C., 2013. Radionucleides, Technologies andq uality control in brachy therapy. Cancer/Radiothérapie. 17( 2): 85-88.
  • Masucci G. L., Donath D., Tétreault-Laflamme A., Carrier J.F., Hervieux Y., Larouche R. X.,BaharyJ.P.,Taussky D., 2010. Comparison between high and low source activity seeds for I-125 permanent seed prostate brachytherapy, International Journal of Radiation Oncology Biology Physics, 78 (3): 781–786.
  • Fontanesi J., Meyer D., Xu S., Tai D., 1993. Treatment of choroidal melanoma with I-125 plaque, International Journal of Radiation Oncology Biology Physics. 26 (4): 619-623.
  • Qaim S.M., 2004. Use of cyclotrons in medicine, Radiation Physics and Chemistry, 71: 917–926.
  • Zhuikov B.L., 2004.Production of medical radionuclides in Russia: Status and future—a review, Applied Radiation and Isotopes, 84: 48–56.
  • Koning A., Hilaire S., Goriely S., 2013. TALYS–1.6 A Nuclear Reaction Program, User Manual (NRG, The Netherlands), First Edition: December, 23: 64–67.
  • Herman M., Capote R., Carlson B. V., Obložinský P., Sin M., Trkov A.,Wienke H.,Zerkin, V., 2007. EMPIRE: Nuclear reaction model code system for data evaluation, Nuclear Data Sheets, 108 (12): 2655–2715.
  • Cline C.K., 1972. The Pauli exclusion principle in pre-equilibrium decay, Nuclear Physics A, 195: 353-360.
  • I. Ribansky et al., 1973, Pre-equilibrium decay and the exciton model, Nuclear Physics A, 205:545-560.
  • Herman M., Capote R., Sin M., Trkov A., 2012.EMPIRE–3.1 Rivoli modular system for nuclear reaction calculations and nuclear data evaluation. User's Manual.
  • Brookhaven National Laboratory, National Nuclear Data Center, EXFOR/CSISRS (Experimental Nuclear Reaction Data File). Database Version of August 20, 2014 (http://www.nndc.bnl.gov/exfor/) (2014)
  • Veli Çapalı e-mail: velicapali@gmail.com
  • İsmail Hakkı Sarpün e-mail: isarpun@aku.edu.tr
  • Abdullah Kaplan e-mail: abdullahkaplan@sdu.edu.tr
There are 14 citations in total.

Details

Primary Language English
Subjects Metrology, Applied and Industrial Physics
Journal Section Makaleler
Authors

Bayram Demir

Veli Çapalı

İsmail Sarpün This is me

Abdullah Kaplan

Publication Date November 22, 2015
Published in Issue Year 2015 Volume: 10 Issue: 2

Cite

IEEE B. Demir, V. Çapalı, İ. Sarpün, and A. Kaplan, “Production Cross–Section Calculations of Medical125I Radionuclide Using α, d and γ Induced Reactions”, Süleyman Demirel University Faculty of Arts and Science Journal of Science, vol. 10, no. 2, pp. 116–121, 2015.