Year 2016, Volume 11 , Issue 1, Pages 51 - 60 2016-05-24

Akciğer Kanseri Radyoterapisinde Solunumun Doz Dağılımlarına Etkisi: Bir Fantom Çalışması
The Effect of Respiratory on Dose Distributions in Radiotherapy of Lung Cancer: A Phantom Study

Sultan DAMGACI [1] , Uğur AKBAŞ [2] , Canan KÖKSAL [3] , Veli ÇAPALI [4] , Murat OKUTAN [5] , Bayram DEMİR [6]


Organ hareketleri, özellikle akciğer ışınlamaları sırasında nefes alıp vermeden kaynaklanan hareketler, radyoterapi için en önemli zorluklardandır. Özellikle akciğer gibi hareketli organlarda bulunan tümörler için hedef hacme (Clinical Target Volume-CTV, Planning Target Volume- PTV) verilecek marj sınırı hakkında herhangi bir fikir birliği yoktur. Bunun yanında, literatürde solunum hareketlerinin PTV marjlarına bağlı olarak radyoterapi dozlarına etkisini gösteren sistematik bir fontom çalışması bulunmamaktadır. Bu çalışmada amaç, PTV marjlarının genişlemesinin, organ hareketlerinin radyoterapi dozlarına etkileri üzerindeki başarısını ölçmektir. Çalışma GaF-Chromic EBT filmlerin bir göğüs kafesi fantomuna yerleştirilmesiyle gerçekleştirilmiştir. Fantom içerisindeki bir silindirik bölüm ışınlama sırasında 5 saniyelik periyotlarla, 3 cm genlikle ayak-baş doğrultusunda hareket etmektedir. 3 cm genlikli hareketin olduğu durum için alınan profillerden 3 Boyutlu Konformal Radyoterapi (3D-CRT), Yoğunluk Ayarlı Radyoterapi (IMRT), Yoğunluk Ayarlı Arc Tedavi (VMAT) planları dar marjlar için incelendiğinde, PTV’nin yeterli doz alamadığı gözlemlenmiştir. Işınlama CTV için daha geniş marjlarda iyileşmekte, ancak PTV için inhomojenite devam etmektedir. Sonuç olarak, marjların genişletilmesinin organ hareketlerinin radyoterapi dozları üzerindeki olumsuz etkileri için tek başına yeterli olmadığı gözlemlenmiştir. 

Internal organ motions are one of the most significant obstacles for radiotherapy, especially in the case of motions caused by respiratory during the lung irradiation. There is no any consensus about the margin limit given for the target volume (Clinical Target Volume-CTV, Planning Target Volume- PTV etc.), especially for tumors located moving organs such as lung. Besides, as far as we know, there is no any systematic phantom study showed the effects of respiratory motions on radiotherapy doses depending on PTV margins in the literature. In present study, our aim was to determine the success degree of enlarging the PTV margins on radiotherapy doses during the moving organ irradiations. The study was performed by using GaF-Chromic EBT films placed to a thorax phantom. A cylindrical part within the phantom can move on through craniocaudal direction with a range of 3 cm with 5 sec. period during the irradiation. From the profiles which were obtained from 3 cm moving situations for 3D-Conformal Radiotherapy (3D-CRT), Intensity Modulated Radiotherapy (IMRT) and Volumetric Modulated Arc
Therapy (VMAT) with narrow margins, it was observed that PTV cannot get adequate dose. The irradiation was better for CTV with larger margins but there was still inhomogeneity for PTV. As a consequence, enlarging the margins alone is not a sufficient method against the negative effects of organ motions on the radiotherapy doses.

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Primary Language en
Subjects Physics, Applied
Journal Section Makaleler
Authors

Author: Sultan DAMGACI

Author: Uğur AKBAŞ

Author: Canan KÖKSAL

Author: Veli ÇAPALI

Author: Murat OKUTAN

Author: Bayram DEMİR

Dates

Publication Date : May 24, 2016

Bibtex @research article { sdufeffd270033, journal = {Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi}, issn = {}, eissn = {1306-7575}, address = {}, publisher = {Süleyman Demirel University}, year = {2016}, volume = {11}, pages = {51 - 60}, doi = {}, title = {The Effect of Respiratory on Dose Distributions in Radiotherapy of Lung Cancer: A Phantom Study}, key = {cite}, author = {Damgacı, Sultan and Akbaş, Uğur and Köksal, Canan and Çapalı, Veli and Okutan, Murat and Demi̇r, Bayram} }
APA Damgacı, S , Akbaş, U , Köksal, C , Çapalı, V , Okutan, M , Demi̇r, B . (2016). The Effect of Respiratory on Dose Distributions in Radiotherapy of Lung Cancer: A Phantom Study . Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi , 11 (1) , 51-60 . Retrieved from https://dergipark.org.tr/en/pub/sdufeffd/issue/25595/270033
MLA Damgacı, S , Akbaş, U , Köksal, C , Çapalı, V , Okutan, M , Demi̇r, B . "The Effect of Respiratory on Dose Distributions in Radiotherapy of Lung Cancer: A Phantom Study" . Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi 11 (2016 ): 51-60 <https://dergipark.org.tr/en/pub/sdufeffd/issue/25595/270033>
Chicago Damgacı, S , Akbaş, U , Köksal, C , Çapalı, V , Okutan, M , Demi̇r, B . "The Effect of Respiratory on Dose Distributions in Radiotherapy of Lung Cancer: A Phantom Study". Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi 11 (2016 ): 51-60
RIS TY - JOUR T1 - The Effect of Respiratory on Dose Distributions in Radiotherapy of Lung Cancer: A Phantom Study AU - Sultan Damgacı , Uğur Akbaş , Canan Köksal , Veli Çapalı , Murat Okutan , Bayram Demi̇r Y1 - 2016 PY - 2016 N1 - DO - T2 - Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi JF - Journal JO - JOR SP - 51 EP - 60 VL - 11 IS - 1 SN - -1306-7575 M3 - UR - Y2 - 2020 ER -
EndNote %0 Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi The Effect of Respiratory on Dose Distributions in Radiotherapy of Lung Cancer: A Phantom Study %A Sultan Damgacı , Uğur Akbaş , Canan Köksal , Veli Çapalı , Murat Okutan , Bayram Demi̇r %T The Effect of Respiratory on Dose Distributions in Radiotherapy of Lung Cancer: A Phantom Study %D 2016 %J Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi %P -1306-7575 %V 11 %N 1 %R %U
ISNAD Damgacı, Sultan , Akbaş, Uğur , Köksal, Canan , Çapalı, Veli , Okutan, Murat , Demi̇r, Bayram . "The Effect of Respiratory on Dose Distributions in Radiotherapy of Lung Cancer: A Phantom Study". Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi 11 / 1 (May 2016): 51-60 .
AMA Damgacı S , Akbaş U , Köksal C , Çapalı V , Okutan M , Demi̇r B . The Effect of Respiratory on Dose Distributions in Radiotherapy of Lung Cancer: A Phantom Study. Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi. 2016; 11(1): 51-60.
Vancouver Damgacı S , Akbaş U , Köksal C , Çapalı V , Okutan M , Demi̇r B . The Effect of Respiratory on Dose Distributions in Radiotherapy of Lung Cancer: A Phantom Study. Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi. 2016; 11(1): 51-60.
IEEE S. Damgacı , U. Akbaş , C. Köksal , V. Çapalı , M. Okutan and B. Demi̇r , "The Effect of Respiratory on Dose Distributions in Radiotherapy of Lung Cancer: A Phantom Study", Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi, vol. 11, no. 1, pp. 51-60, May. 2016