Year 2020, Volume 15 , Issue 1, Pages 130 - 139 2020-05-31

Torasik Özofagus Karsinomunda 3D-CRT, IMRT, IMAT ve Helical Tomoterapinin Dozimetrik Karşılaştırması
Dosimetric Comparison of 3D-CRT, IMRT, IMAT and Helical Tomotherapy for Thoracic Esophageal Carcinoma

Murat OKUTAN [1] , Şeyda UYANIK BAYRAM [2] , Canan KÖKSAL [3] , Evren Ozan GÖKSEL [4] , Şule KARAMAN [5] , Yunus Emre AKPINAR [6] , Nergiz DAĞOĞLU [7] , Bayram DEMİR [8]


Bu çalışmada, torasik özofagus kanserinin tedavisi için 3D-CRT, IMRT, IMAT ve HT tedavi planlarının doz-hacim parametrelerini karşılaştırdık. Çalışma için kliniğimizde 2017-2018 yılları arasında tedavi edilen 15 torasik özofagus hastası seçildi. PTV hacimleri 205 cc ile 445.4 cc arasındaydı ve ortalama değer 355,2 cc idi. Her hasta için aynı konturları ve aynı doz planlama reçetesini kullanarak 3D-CRT, IMRT, IMAT ve HT radyoterapi planları oluşturuldu. Her bir plan için, toplam 28 fraksiyon ile fraksiyon başına 180 cGy doz ile toplamda 50,4 Gy'lik bir doz uygulanmıştır. PTV için; dört tedavi tekniği karşılaştırıldığında HI değerleri 3D-CRT için 0,84 ± 0,0, IMRT için 0,57 ± 0,05, IMAT için 0,06 ± 0,013 ve HT için 0,08 ± 0,03 (p <0.05) bulundu. CI değerleri için ise 3D-CRT için 1,84 ± 0,2, IMRT için 1,25 ± 0,05, IMAT için 1,19 ± 0,04 ve HT için 1,2 ± 0.06 (p <0,05) vardı. IMRT ve IMAT teknikleri, tüm akciğer ve kalp dozu karşılaştırmalarında, diğer tekniklere kıyasla daha iyi OAR koruması sağlamıştır. Omurilik Dmax ve D1% dozları için en düşük dozlar HT tekniği ile sağlanmıştır. IMRT, IMAT ve HT tekniklerinin torasik özofagus kanserini tedavi etmek için 3D-CRT tekniğinden daha düşük kritik organ dozlarına sahip olduğunu bulduk. Çalışmamızda özofagus kanseri tedavisinden sonra radyasyona bağlı kardiyak toksisite ile doz-hacim parametreleri arasındaki ilişkinin literatürdeli mevcut kanıtları da göz önüne alındığında, IMRT ve IMAT planları için doz planlarının 3D-CRT ve HT'den akciğer ve kalp dozları açısından daha iyi olduğunu söyleyebiliriz.

In this study, we compared the dose-volume parameters for treatment of thoracic esophageal cancer with treatment plans for 3D-CRT, IMRT, IMAT and HT. 15 thoracic esophagus patients who were treated in our clinic between 2017-2018 years were selected. PTV volumes were between 205 and 445.4 cc with an average of 355.2 cc. 3D-CRT, IMRT, IMAT and HT radiotherapy plans were created for each patient using the same contours and the same dose planning prescription. Total dose of 50.4 Gy for all patients was planed with 180 cGy dose per a fraction in total 28 fractions. For PTV; when the four treatment techniques were compared, HI values were 3D-CRT 0.84 ± 0.0, IMRT 0.57 ± 0.05, IMAT 0.06 ± 0.013, HT 0.08 ± 0.03 (p <0.05). CI values were found for 3D-CRT as 1.84 ± 0.2, for IMRT as 1.25 ± 0.05, for IMAT as 1.19 ± 0.04, for HT as 1.2 ± 0.06 (p <0.05). IMRT and IMAT techniques provided better OAR protection compared to other techniques in all lung and heart comparisons. The lowest doses for Dmax and D1% of Spinal Cord were provided by HT technique. We found that IMRT, IMAT and HT techniques have lower critical organ doses than 3D-CRT technique for treating torasic esophageal cancer. Considering the current evidence of the relationship between radiation-induced cardiac toxicity in the literature and the dose-volume parameters after treatment for esophageal cancer in our study, we can say that dose plans are better for IMRT and IMAT plans than 3D-CRT and HT in terms of lung and heart doses.

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Primary Language en
Subjects Physics, Applied
Journal Section Makaleler
Authors

Orcid: 0000-0002-2276-631X
Author: Murat OKUTAN (Primary Author)
Institution: ISTANBUL UNIVERSITY, INSTITUTE OF ONCOLOGY
Country: Turkey


Orcid: 0000-0001-7560-734X
Author: Şeyda UYANIK BAYRAM
Institution: ISTANBUL UNIVERSITY, INSTITUTE OF ONCOLOGY
Country: Turkey


Orcid: 0000-0001-6429-5272
Author: Canan KÖKSAL
Institution: ISTANBUL UNIVERSITY, INSTITUTE OF ONCOLOGY
Country: Turkey


Orcid: 0000-0002-0674-1016
Author: Evren Ozan GÖKSEL
Institution: ACIBADEM MEHMET ALI AYDINLAR UNIVERSITY, VOCATIONAL SCHOOL
Country: Turkey


Orcid: 0000-0002-4810-4453
Author: Şule KARAMAN
Institution: ISTANBUL UNIVERSITY, INSTITUTE OF ONCOLOGY
Country: Turkey


Orcid: 0000-0001-5216-6289
Author: Yunus Emre AKPINAR
Institution: İSTANBUL FACULTY OF MEDICINE
Country: Turkey


Orcid: 0000-0003-3425-3382
Author: Nergiz DAĞOĞLU
Institution: ISTANBUL UNIVERSITY, INSTITUTE OF ONCOLOGY
Country: Turkey


Orcid: 0000-0001-6815-6384
Author: Bayram DEMİR
Institution: FACULTY OF SCIENCE
Country: Turkey


Dates

Publication Date : May 31, 2020

Bibtex @research article { sdufeffd698994, journal = {Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi}, issn = {}, eissn = {1306-7575}, address = {}, publisher = {Süleyman Demirel University}, year = {2020}, volume = {15}, pages = {130 - 139}, doi = {10.29233/sdufeffd.698994}, title = {Dosimetric Comparison of 3D-CRT, IMRT, IMAT and Helical Tomotherapy for Thoracic Esophageal Carcinoma}, key = {cite}, author = {Okutan, Murat and Uyanık, Şeyda and Köksal, Canan and Göksel, Evren and Karaman, Şule and Akpınar, Yunus and Dağoğlu, Nergiz and Demi̇r, Bayram} }
APA Okutan, M , Uyanık, Ş , Köksal, C , Göksel, E , Karaman, Ş , Akpınar, Y , Dağoğlu, N , Demi̇r, B . (2020). Dosimetric Comparison of 3D-CRT, IMRT, IMAT and Helical Tomotherapy for Thoracic Esophageal Carcinoma . Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi , 15 (1) , 130-139 . DOI: 10.29233/sdufeffd.698994
MLA Okutan, M , Uyanık, Ş , Köksal, C , Göksel, E , Karaman, Ş , Akpınar, Y , Dağoğlu, N , Demi̇r, B . "Dosimetric Comparison of 3D-CRT, IMRT, IMAT and Helical Tomotherapy for Thoracic Esophageal Carcinoma" . Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi 15 (2020 ): 130-139 <https://dergipark.org.tr/en/pub/sdufeffd/issue/54573/698994>
Chicago Okutan, M , Uyanık, Ş , Köksal, C , Göksel, E , Karaman, Ş , Akpınar, Y , Dağoğlu, N , Demi̇r, B . "Dosimetric Comparison of 3D-CRT, IMRT, IMAT and Helical Tomotherapy for Thoracic Esophageal Carcinoma". Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi 15 (2020 ): 130-139
RIS TY - JOUR T1 - Dosimetric Comparison of 3D-CRT, IMRT, IMAT and Helical Tomotherapy for Thoracic Esophageal Carcinoma AU - Murat Okutan , Şeyda Uyanık , Canan Köksal , Evren Göksel , Şule Karaman , Yunus Akpınar , Nergiz Dağoğlu , Bayram Demi̇r Y1 - 2020 PY - 2020 N1 - doi: 10.29233/sdufeffd.698994 DO - 10.29233/sdufeffd.698994 T2 - Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi JF - Journal JO - JOR SP - 130 EP - 139 VL - 15 IS - 1 SN - -1306-7575 M3 - doi: 10.29233/sdufeffd.698994 UR - https://doi.org/10.29233/sdufeffd.698994 Y2 - 2020 ER -
EndNote %0 Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi Dosimetric Comparison of 3D-CRT, IMRT, IMAT and Helical Tomotherapy for Thoracic Esophageal Carcinoma %A Murat Okutan , Şeyda Uyanık , Canan Köksal , Evren Göksel , Şule Karaman , Yunus Akpınar , Nergiz Dağoğlu , Bayram Demi̇r %T Dosimetric Comparison of 3D-CRT, IMRT, IMAT and Helical Tomotherapy for Thoracic Esophageal Carcinoma %D 2020 %J Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi %P -1306-7575 %V 15 %N 1 %R doi: 10.29233/sdufeffd.698994 %U 10.29233/sdufeffd.698994
ISNAD Okutan, Murat , Uyanık, Şeyda , Köksal, Canan , Göksel, Evren , Karaman, Şule , Akpınar, Yunus , Dağoğlu, Nergiz , Demi̇r, Bayram . "Dosimetric Comparison of 3D-CRT, IMRT, IMAT and Helical Tomotherapy for Thoracic Esophageal Carcinoma". Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi 15 / 1 (May 2020): 130-139 . https://doi.org/10.29233/sdufeffd.698994
AMA Okutan M , Uyanık Ş , Köksal C , Göksel E , Karaman Ş , Akpınar Y , Dağoğlu N , Demi̇r B . Dosimetric Comparison of 3D-CRT, IMRT, IMAT and Helical Tomotherapy for Thoracic Esophageal Carcinoma. SDÜFEFFD. 2020; 15(1): 130-139.
Vancouver Okutan M , Uyanık Ş , Köksal C , Göksel E , Karaman Ş , Akpınar Y , Dağoğlu N , Demi̇r B . Dosimetric Comparison of 3D-CRT, IMRT, IMAT and Helical Tomotherapy for Thoracic Esophageal Carcinoma. Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi. 2020; 15(1): 130-139.