Karotis Sinüs Baroreseptörlerinin Kronik Uyarılmasının Arter Basıncı Üzerine Etkisinin Matematik Model Kullanılarak Analizi

Abstract

İnsan vücudunda arteriyel kan basıncı arttığında ya da azaldığında arter duvarlarında yerleşmiş halde bulunan baroreseptörler gerilerek merkezi sinir sistemine arter basıncını düşürecek ya da yükseltecek sinyaller gönderirler. Karotis sinüs baroreseptörlerinin elektriksel olarak uyarılmasıyla kan basıncının azaldığı deneysel çalışmalar mevcuttur ancak bunun gerçekleşmesini sağlayan mekanizmalar tam olarak tanımlanmamıştır. Bu çalışmada karotis sinüs baroreseptörlerinin kronik uyarılmasının arter basıncı ve idrar sodyum debisi üzerine etkisi uzun dönemli dolaşım sistemi matematik modeli kullanılarak analiz edilmiştir. Modele göre karotis baroreseptörlerinin kronik uyarılmasında böbrekten sodyum atılımının azalmasının sebebi glomerüler filtrasyon hızının azalmasıdır. Diğer bir deyişle, arter damar direnci azaldığında, azalan arter kan basıncının glomerüler filtrasyon hızını azaltıcı etkisi, azalmış böbrek sempatik sinir aktivitesinin glomerüler filtrasyon hızını artırıcı etkisinden fazladır.

Keywords

• Kan basıncı
• Baroreseptörler
• Matematik Model
• Simülasyon

Analysis of The Effect of Chronic Stimulation of Carotid Sinus Baroreceptor on Arterial Pressure by Using a Mathematical Model

Abstract

When arterial blood pressure increases or decreases baroreceptors that have placed arterial walls strecth and send signals to the central nervous system will increase or decrease arterial pressure. There are experimental studies that reduced the blood pressure by chronic stimulation of carotid sinus baroreceptors but the mechanisms by which this makes happen are not fully defined. In this study, a long-term cardiovascular system mathematical model has been used to examine the effect of chronic stimulation of carotid sinus baroreceptors on arterial pressure and urinary sodium flow. According to the model , the reason for the decrease in sodium excretion from the kidney in the stimulation of carotid sinus baroreceptors is declining in the glomerular filtration rate. In other words, when the total peripheral resistance decreases, the effect of decreased total peripheral resistance on reducing to glomerular filtration rate is more than the effect of decreased renal sympathetic nerve activity on raising to glomerular filtration rate.

Keywords

• Blood pressure
• Baroreceptors
• Mathematical model
• Simulation

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