Sono-Fotokimyasal Yöntemle Arttırılmış Singlet Oksijen Oluşumuna Sahip Yeni Furan-İmin Sübstitüeli Çinko Ftalosiyanin

Abstract

Bu çalışma, furan-imin sübstitüentine sahip yeni çinko ftalosiyaninin (3) fotokimyasal ve sonofotokimyasal özellikleri arasındaki ilişkiyi, kompleksin sentezi ve karakterizasyonu ile birlikte göstermeyi amaçlamaktadır. Kompleksin (3) DMSO'daki singlet oksijen kuantum verimini hesaplamak ve karşılaştırmak için hem fotokimyasal hem de sono-fotokimyasal teknikler uygulandı. Kompleksin (3) singlet oksijen kuantum verimini hesaplamak ve karşılaştırmak için hem fotokimyasal hem de sono-fotokimyasal teknikler uygulanmıştır. Kompleksin (3) singlet oksijen kuantum verimi PDT yöntemi (sadece ışık ışınlaması) ile 0.12 olarak hesaplanmış iken, bu değer SPDT yöntemi (ışık ve ultrasonun kombinasyonu) ile 0.78'e çıkarılmıştır. Singlet oksijen üretim verimliliği göz önüne alındığında, SPDT yönteminin PDT yönteminden daha güçlü bir terapötik yaklaşım olduğu ve ayrıca kompleksin (3) hem PDT hem de SPDT uygulamalarında uygun bir sono/fotosensitizer adayı olabileceği söylenebilir. Bu çalışma aynı zamanda, SPDT yöntemini kullanarak singlet oksijen üretimini artırmaya yönelik alana katkıda bulunacaktır.

Keywords

• Fotodinamik terapi
• Sonofotodinamik terapi
• Singlet oksijen kuantum verimi
• Çinko ftalosiyanin

Novel Furan-Imine Substituted Zinc Phthalocyanine with Increased Singlet Oxygen Formation by Sono-Photochemical Method

Abstract

This work aims to show the relationship between photochemical and sonophotocehmical features of novel zinc phthalocyanine having furan-imine substituent along with synthesis and characterization of complex (3). Both photochemical and sono-photochemical techniques were applied in order to calculate and compare the singlet oxygen quantum yield of the complex (3) in DMSO. The singlet oxygen quantum yield of the complex (3) was determined as 0.12 by the PDT method (irradiated with only light), while the value of 0.78 was reached by the SPDT approach (combination of light and ultrasound). Considering the efficiency in singlet oxygen formation, it can be said that the SPDT modality is a more powerful therapeutic solution than the PDT technique and also the complex (3) may be a suitable sono/photosensitizer candidate in both PDT and SPDT tecniques. This study will also contribute to the field on enhancing singlet oxygen generation by using SPDT approach.

Keywords

• Photodynamic therapy
• Sonophotodynamic therapy
• Singlet oxygen quantum yield
• Zinc phthalocyanine

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