Pirolidinin Alkollerle Rutenyum-NHC Katalizli N-Alkilasyonu

Abstract

Bu çalışmada, N-heterosiklik karben (NHC) ligandı içeren, [RuCl2(η6-p-simen) (NHC)] genel formülüne sahip yarı sandviç tipi iki yeni rutenyum-NHC kompleksi sentezlendi. Sentezlenen komplekslerin yapıları spektroskopik ve analitik yöntemlerle karakterize edildi. Rutenyum-NHC kompleksleri, pirolidin ve çeşitli alkol türevlerinin hidrojen ödünç alma yöntemiyle N-alkilasyonunda katalizör olarak kullanıldı. Katalitik tepkimeler, %1 mol katalizör yüklemesi varlığında 120 °C'de, 16 saatte ve çözücüsüz tepkime ortamında gerçekleştirildi. Tüm rutenyum-NHC kompleksleri, test edilen koşullar altında oldukça iyi katalitik aktivite gösterdi ve hedeflenen N-alkilpirolidin ürünleri yüksek seçicilikte elde edildi.

Keywords

• Kataliz
• Rutenyum
• Pirolidin
• N-alkilasyon

Ruthenium-NHC Catalysed N-Alkylation of Pyrrolidine with Alcohols

Abstract

In this study, two new half-sandwich type ruthenium-NHC complexes with the general formula [RuCl2(η6-p-cymene)(NHC)] containing N-heterocyclic carbene (NHC) ligands were synthesised. The structures of the synthesised complexes were characterised by spectroscopic and analytical methods. The ruthenium-NHC complexes were used as catalysts in the N-alkylation of pyrrolidine and various alcohol derivatives by hydrogen borrowing strategy. The catalytic reactions were carried out in the presence of 1 mol% catalyst loading at 120 °C for 16 h in a solvent-free reaction medium. All ruthenium-NHC complexes showed very good catalytic activity under the tested conditions and the targeted N-alkylpyrrolidine products were obtained with high selectivity.

Keywords

• Catalysis
• Ruthenium
• Pyrrolidine
• N-Alkylation

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