Effect of New Water-Soluble Dendritic Phthalocyanines on Human Colorectal and Liver Cancer Cell Lines

Volume: 21 Number: 3 August 8, 2017

Effect of New Water-Soluble Dendritic Phthalocyanines on Human Colorectal and Liver Cancer Cell Lines

Abstract

Human hepatocellular carcinoma (HepG2) cells and colorectal adenocarcinoma (DLD-1) cells were treated with the synthesized water soluble phthalocyanine derivatives to understand the effect of the compounds both on colorectal and liver cancer cells. The compounds inhibited cell proliferation and displayed cytotoxic effect on these cancer cell lines however; the effect of the compounds on healthy control fibroblast cell line was comparatively lower. The compounds can be employed for cancer treatment as anticancer agents.

Keywords

References

  1. [1] Ece, E., Kilickap, S., Özgür, A., Tutar, Y. 2015. Treatment of Colorectal Cancer Liver Metastases: Clinical and Molecular Aspects. OMICS Group, USA.
  2. [2] Misiakos, E. P., Karidis, N. P., Kouraklis,G. 2011. Current treatment for colorectal liver metastases. World Journal of Gastroenterology, 17(2011), 4067-4075.
  3. [3] Newkome, G. R., Moorefield, C. N., Vogtle, F. 2002. Dendrimers and Dendrons. Witey-VCH Verlag GmbH.
  4. [4] Vögtle, F., Richardt, G., Werner N. 2009. Dendrimer Chemistry. Witey-VCH Verlag GmbH.
  5. [5] Scheirs, J. 2001. Dendrimers and Other Dendritic Polymers. John Wiley & Sons.
  6. [6] Zhang, Y., Thomas, T. P., Lee, K. H., Li, Zong, M. H., Desai, A. M., Kotlyar, A., Huang, B., Holl, M. M. B., Baker Jr., J. R. 2011. Polyvalent saccharide-functionalized generation 3 poly(amidoamine)dendrimer-methotrexate conjugate as a potential anticancer agent. Bioorganic& Medicinal Chemistry, 19(2011), 2557-2564.
  7. [7] Johansson, E. M. V., Dubois, J., Darbre, T., Reymond, J. L. 2010. Glycopeptide dendrimer colchicine conjugates targeting cancer cells. Bioorganic&Medicinal Chemistry, 18(2010), 6589-6597.
  8. [8] Abdel-Rahman, M. A., Al-Abd, A. M. 2013. Thermoresponsive dendrimers based on oligoethylene glycols: Design, synthesis and cytotoxic activity against MCF-7 breast cancer cells. European Journal of Medicinal Chemistry, 69(2013), 848-854.

Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Mustafa Sülü This is me

Aykut Özgür This is me

Yusuf Tutar This is me

Publication Date

August 8, 2017

Submission Date

March 27, 2017

Acceptance Date

-

Published in Issue

Year 2017 Volume: 21 Number: 3

APA
Yabaş, E., Sülü, M., Özgür, A., & Tutar, Y. (2017). Effect of New Water-Soluble Dendritic Phthalocyanines on Human Colorectal and Liver Cancer Cell Lines. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 21(3), 689-695. https://doi.org/10.19113/sdufbed.89035
AMA
1.Yabaş E, Sülü M, Özgür A, Tutar Y. Effect of New Water-Soluble Dendritic Phthalocyanines on Human Colorectal and Liver Cancer Cell Lines. J. Nat. Appl. Sci. 2017;21(3):689-695. doi:10.19113/sdufbed.89035
Chicago
Yabaş, Ebru, Mustafa Sülü, Aykut Özgür, and Yusuf Tutar. 2017. “Effect of New Water-Soluble Dendritic Phthalocyanines on Human Colorectal and Liver Cancer Cell Lines”. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi 21 (3): 689-95. https://doi.org/10.19113/sdufbed.89035.
EndNote
Yabaş E, Sülü M, Özgür A, Tutar Y (December 1, 2017) Effect of New Water-Soluble Dendritic Phthalocyanines on Human Colorectal and Liver Cancer Cell Lines. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi 21 3 689–695.
IEEE
[1]E. Yabaş, M. Sülü, A. Özgür, and Y. Tutar, “Effect of New Water-Soluble Dendritic Phthalocyanines on Human Colorectal and Liver Cancer Cell Lines”, J. Nat. Appl. Sci., vol. 21, no. 3, pp. 689–695, Dec. 2017, doi: 10.19113/sdufbed.89035.
ISNAD
Yabaş, Ebru - Sülü, Mustafa - Özgür, Aykut - Tutar, Yusuf. “Effect of New Water-Soluble Dendritic Phthalocyanines on Human Colorectal and Liver Cancer Cell Lines”. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi 21/3 (December 1, 2017): 689-695. https://doi.org/10.19113/sdufbed.89035.
JAMA
1.Yabaş E, Sülü M, Özgür A, Tutar Y. Effect of New Water-Soluble Dendritic Phthalocyanines on Human Colorectal and Liver Cancer Cell Lines. J. Nat. Appl. Sci. 2017;21:689–695.
MLA
Yabaş, Ebru, et al. “Effect of New Water-Soluble Dendritic Phthalocyanines on Human Colorectal and Liver Cancer Cell Lines”. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi, vol. 21, no. 3, Dec. 2017, pp. 689-95, doi:10.19113/sdufbed.89035.
Vancouver
1.Ebru Yabaş, Mustafa Sülü, Aykut Özgür, Yusuf Tutar. Effect of New Water-Soluble Dendritic Phthalocyanines on Human Colorectal and Liver Cancer Cell Lines. J. Nat. Appl. Sci. 2017 Dec. 1;21(3):689-95. doi:10.19113/sdufbed.89035

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