Synthesis and Analysis of Antimicrobial Properties of Macrocyclic Compounds Containing Thiophene and Furan Rings

Abstract

Macrocylic compounds  are functional compounds which have  different applications in many fields of chemistry. In this work, new macrocyclic ethers containing furan and thiophene rings were obtained in good yields using different methods. In addition, antimicrobial activities of these compounds against Escherichia coli ATCC 25922, Salmonella thphimurium ATCC 14028, Staphylococcus aureus ATCC 25923, Bacillus cereus ATCC 11778, and Listeria monocytogenes ATCC 19115 bacteria and antifungal activity on Candida albicans ATCC 10231 were investigated. It has been found that the synthesized compounds show a moderate effect against some bacterial species.    

Keywords

• Crown ether,Macrocyclic,Antimicrobial,Furan,Thiophene

Tiyofen ve Furan Halkaları İçeren Makrosiklik Bileşiklerinin Sentezleri ve Antimikrobiyal Özelliklerinin İncelenmesi

Abstract

Makrosiklik bileşikler, kimyanın pek çok alanında farklı uygulamalara sahip işlevsel bileşiklerdir. Bu çalışmada da furan ve tiyofen heterosiklik halkalarını içeren yeni makrosiklik eterler farklı reaksiyon şartları denenerek, en verimli şekilde sentezlenmiştir. Ayrıca sentezlenen bu bileşiklerin Escherichia coli ATCC 25922, Salmonella thphimurium ATCC 14028, Staphylococcus aureus ATCC 25923, Bacillus cereus ATCC 11778 ve Listeria monocytogenes ATCC 19115 bakterilerine karşı antimikrobiyal aktiviteleri, Candida albicans ATCC 10231 mayaları üzerinde antifungal aktiviteleri incelenmiştir. Sentezlenen bileşiklerin bazı bakteri türlerine karşı ılımlı etki gösterdiği bulunmuştur.

Keywords

• Taç eter,Makrosiklik,Antimikrobiyal,Furan,Tiyofen

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