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A New Drug-Shelf Arrangement for Reducing Medication Errors using Data Mining: A Case Study

Year 2017, Volume: 21 Issue: 3, 774 - 781, 19.09.2017

Abstract

Medication errors are common, fatal, costly but preventable. Location of drugs on the shelves and wrong drug names in prescriptions can cause errors during dispensing process. Therefore, a good drug-shelf arrangement system in pharmacies is crucial for preventing medication errors, increasing patient’s safety, evaluating pharmacy performance, and improving patient outcomes. The main purpose of this study to suggest a new drug-shelf arrangement for the pharmacy to prevent wrong drug selection from shelves by the pharmacist. The study proposes an integrated structure with three-stage data mining method using patient prescription records in database. In the first stage, drugs on prescriptions were clustered depending on the Anatomical Therapeutic Chemical (ATC) classification system to determine associations of drug utilizations. In the second stage association rule mining (ARM), well-known data mining technique, was applied to obtain frequent association rules between drugs which tend to be purchased together. In the third stage, the generated rules from ARM were used in multidimensional scaling (MDS) analysis to create a map displaying the relative location of drug groups on pharmacy shelves. The results of study showed that data mining is a valuable and very efficient tool which provides a basis for potential future investigation to enhance patient safety.

References

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  • [8] Institute for Safe Medication Practices. Improving Medication Safety in Community Pharmacy: Assessing Risk and Opportunities for change ISMP. 2009. http://www.ismp.org/communityRx/aroc/.
  • [9] Oh H.C., Wong J.A., Tan M.C. 2014. Enhancement of patient and staff experience at outpatient pharmacy via optimization of drug–shelf reallocation. Operations Research for Health Care, 3(1), 15–21.
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  • [13] Bohand X., Aupee O., Le Garlantezec P., Mullot H., Lefeuvre L., Simon L. 2009. Medication dispensing errors in a French military hospital pharmacy. Pharm World Sci., 31, 432-438.
  • [14] Taylor J., Gaucher M. 1986. Medication selection errors made by pharmacy technicians in filling unit dose orders. Can J Hosp Pharm., 39, 9–12.
  • [15] Cina J.L., Gandhi T.K., Churchill W., Fanikos J., McCrea M., Mitton P., et al. 2006. How many hospital pharmacy medication dispensing errors go undetected? Jt Comm J Qual Patient Saf., 32, 73-80.
  • [16] Klein E.G., Santora J.A., Pascale P.M., Kitrenos J.G. 1994. Medication cart filling time accuracy, and cost with an automated dispensing system. Am J Hosp Pharm., 51, 1193–6.
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  • [20] Han J., Kamber M., Pei J. 2012. Data Mining Concepts and Techniques (3rd ed.) USA, Morgan Kaufmann Publishers.
  • [21] Orozova-Bekkevold I., Jensen H., Stensballe L., Olsen J. 2007. Maternal vaccination and preterm birth: Using data mining as a screening tool. Pharm World Sci., 29, 205–212.
  • [22] Patadia V.K., Schuemie M.J., Coloma P., Herings R., et al. 2015. Evaluating performance of electronic healthcare records and spontaneous reporting data in drug safety signal detection. Int J Clin Pharm., 37(1), 94-104.
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  • [26] Bereznicki B.J., Peterson G.M., Jackson S.L., Walters H., Fitzmaurice K., Gee P. 2008. Pharmacist-initiated general practitioner referral of patients with suboptimal asthma management. Pharmacy World & Science, 30: 869–875.
  • [27] Khader N., Lashier A., Yoon S.W. 2016. Pharmacy robotic dispensing and planogram analysis using association rule mining with prescription data, Expert Systems with Applications, 57, 296-310.
  • [28] Chapman P., Clinton J., Kerber R., Khabaza T., Reinartz T., Shearer C., Wirth R. CRISP-DM 1.0 Step-by-step data mining guide. CRISP-DM Consortium. 2000. http://the-modeling-agency.com/crisp-dm.pdf.
  • [29] Agrawal R., Imielinski T., Swami A. 1993. Mining association rules between sets of items in large databases. In: Proceedings of the ACM SIGMOD international conference on management of data, Washington, DC.
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  • [31] Doddi S., Marathe A., Ravi S.S., Torney D.C. 2001. Discovery of association rules in medical data. Med Inform Internet Med., 26, 25–33.
  • [32] Nguyen P.A., Syed-Abdul S., Iqbal U., Hsu M.H., Huang C.L., Li H.C., Clinciu D.L., Jian W.S., Li Y.C. 2013. A probabilistic model for reducing medication errors. PLoS One, 8(12), e8240.
  • [33] Kim J.W. 2017. Construction and evaluation of structured association map for visual exploration of association rules. Expert systems with applications, 74, 70-81.
  • [34] Huang Y., Britton J., Hubbard R., Lewis S. 2013. Who receives prescriptions for smoking cessation medications? An association rule mining analysis using a large primary care database. Tob Control. 22(4), 274-279.
  • [35] World Health Organization Collaborating Center for Drug Statistics Methodology. Guidelines for ATC classification and DDD assignment. WHOCC. 2013. http://www.whocc.no/filearchive/publications/1_2013guidelines.pdf
  • [36] Rønnig M. 2001. Coding and classification in drug statistics—From national to global application. Nor J Epidemiol, 11, 37–40.
  • [37] Linoff G.S., Berry M.J. 2011. Data mining techniques: For marketing, sales and customer relationship management (3rd ed.) Indianapolis, Wiley Publishing Inc.
  • [38] Kalaichelvi A., Malini P.H., 2011. Application of fuzzy soft sets to investment decision making problem. Internal Journal of Mathematical Sciences and Applications, 1(3), 1583-1586.
  • [39] Yuksel S., Dizman T., Yildizdan G., Sert U. 2013. Application of soft sets to diagnose the prostate cancer risk. Journal of Inequalities and Applications, 229.
  • [40] Özgür N.Y., Taş N. 2015. A Note On "Application of Fuzzy Soft Sets to Investment Decision Making Problem". Journal of New Theory, 1(7), 1-10.
  • [41] Dash S.R., Dehuri S., Sahoo U.K. 2013. Interactions and Applications of Fuzzy, Rough, and Soft Set in Data Mining, International Journal of Fuzzy System Applications, 3(3), 37-50.
  • [42] Feng F., Cho J., Pedrycz W., Fuzita H., Herawan T. 2016. Soft set based association rule mining, Knowledge-Based Systems, Volume 111, 268-282.
  • [43] Kavakiotis I., Tsave O., Salifoglou A., Maglaveras N., Vlahavas I., Chouvarda I. 2017. Machine learning and data mining methods in diabetes research. Computational and Structural Biotechnology Journal, 15, 104-116.
  • [44] Blattberg R.C., Kim B.D., Neslin, S.A. 2008 Database Marketing: Analyzing and Managing Customers. New York, Springer.
  • [45] Borg I., Groenen P. 2005. Modern Multi-dimensional scaling theory and applications. Berlin: Springer.
  • [46] Çil I. 2012. Consumption universes based supermarket layout through association rule mining and multidimensional scaling. Expert Systems with Applications, 39(10), 8611–8625.
  • [47] Jaworska N., Chupetlovska-Anastasova A. 2009. A review of multidimentional scaling (MDS) and its utility in various psychological domains. Tutorials in Quantitative Methods for Psychology, 5(1), 1–10.
  • [48] Kruskal J.B. 1964. Multidimensional scaling by optimizing goodness of fit to a nonmetric hypothesis. Psychometrika, 29, 1–27.
  • [49] Kruskal J.B., Wish M. Multidimensional scaling. Sage University Paper series on Quantitative Applications in the Social Sciences, number 07-011. Newbury Park, CA: Sage Publications; 1978.
  • [50] Turkish Medicines and Medical Device Agency. E-prescription drug list. TMMDA. 2014. http://www.titck.gov.tr/DisplayDynamicModule.aspx?mId=a/0Tp/ovYIU.
  • [51] SPSS Clementine 11.1. User’s Guide http://home.kku.ac.th/wichuda/DMining/ClementineUsersGuide_11.1.pdf
  • [52] Borges A. 2003. Toward a new supermarket layout: from industrial categories to one stop shopping organization through a data mining approach. In: Proceedings of the 2003 society for marketing advances annual symposium on retail patronage and strategy, Montreal, November, 4–5.
  • [53] Mollahaliloglu S., Alkan A., Donertas B., Ozgulcu S, Akıcı A. 2013. Prescribing Practices of Physicians at Different Health Care Institutions. Saudi Pharmaceutical Journal, 21(3), 281-291.
Year 2017, Volume: 21 Issue: 3, 774 - 781, 19.09.2017

Abstract

References

  • [1] World Health Organization. Patient Safety Curriculum Guide Multi Professional Edition. WHO. 2011. http://caipe.org.uk/silo/files/multi-professional-patient-safety-curriculum-guide.pdf
  • [2] National Coordinating Council for Medication Error Reporting and Prevention. What is a medication error? http://www.nccmerp.org/about-medication-errors
  • [3] World Health Organization. Drug and therapeutics committees - A practical guide. WHO. 2003. http://apps.who.int/medicinedocs/en/d/Js4882e/4.html.
  • [4] Food and Drug Administration. FDA 101: Medication Errors. FDA. 2009. http://www.fda.gov/downloads/ForConsumers/ConsumerUpdates/UCM143038.pdf.
  • [5] Emmerton L.M., Rizk M.F. 2012. Look-alike and sound-alike medicines: risks and ‘solutions’. Int J Clin Pharm., 34(1), 4–8.
  • [6] Ciociano N., Bagnasco L. 2014. Look alike/sound alike drugs: a literature review on causes and solutions. Int J Clin Pharm., 36, 233–242.
  • [7] Joint Commission on Accreditation of Healthcare Organizations. Look-alike, sound-alike drug names. JCAHO. 2001. http://www.jointcommission.org/assets/1/18/SEA_19.pdf.
  • [8] Institute for Safe Medication Practices. Improving Medication Safety in Community Pharmacy: Assessing Risk and Opportunities for change ISMP. 2009. http://www.ismp.org/communityRx/aroc/.
  • [9] Oh H.C., Wong J.A., Tan M.C. 2014. Enhancement of patient and staff experience at outpatient pharmacy via optimization of drug–shelf reallocation. Operations Research for Health Care, 3(1), 15–21.
  • [10] Sunny Downstate Medical, Department of Pharmacy Service. Top 10 Sound-Alike & Look-Alike. http://www.downstate.edu/patientsafety/Look_alike_Sound_alike_drug_list.pdf
  • [11] Hoffman J.M., Proulx S.M. 2003. Medication errors caused by confusion of drug names. Drug Saf., 26(7), 445–452.
  • [12] Kenagy J.W., Stein G.C. 2001. Naming, labeling, and packaging of pharmaceuticals. Am J Health-Syst Pharm., 58(21), 2033-41.
  • [13] Bohand X., Aupee O., Le Garlantezec P., Mullot H., Lefeuvre L., Simon L. 2009. Medication dispensing errors in a French military hospital pharmacy. Pharm World Sci., 31, 432-438.
  • [14] Taylor J., Gaucher M. 1986. Medication selection errors made by pharmacy technicians in filling unit dose orders. Can J Hosp Pharm., 39, 9–12.
  • [15] Cina J.L., Gandhi T.K., Churchill W., Fanikos J., McCrea M., Mitton P., et al. 2006. How many hospital pharmacy medication dispensing errors go undetected? Jt Comm J Qual Patient Saf., 32, 73-80.
  • [16] Klein E.G., Santora J.A., Pascale P.M., Kitrenos J.G. 1994. Medication cart filling time accuracy, and cost with an automated dispensing system. Am J Hosp Pharm., 51, 1193–6.
  • [17] Institute for Safe Medication Practices. A Call to Action: Protecting U.S. Citizens from Inappropriate Medication Use. ISMP. 2007. http://www.ismp.org/pressroom/viewpoints/CommunityPharmacy.pdf.
  • [18] Samaranayake N.R., Cheung S.T.D, Chui W.C.M., Cheung B.M.Y. 2013. The pattern of the discovery of medication errors in a tertiary hospital in Hong Kong. Int J Clin Pharm., 2013; 35(3), 432–438.
  • [19] Tan P.N., Steinbach M., Kumar V. 2006. Introduction to data mining. Boston, Pearson Education.
  • [20] Han J., Kamber M., Pei J. 2012. Data Mining Concepts and Techniques (3rd ed.) USA, Morgan Kaufmann Publishers.
  • [21] Orozova-Bekkevold I., Jensen H., Stensballe L., Olsen J. 2007. Maternal vaccination and preterm birth: Using data mining as a screening tool. Pharm World Sci., 29, 205–212.
  • [22] Patadia V.K., Schuemie M.J., Coloma P., Herings R., et al. 2015. Evaluating performance of electronic healthcare records and spontaneous reporting data in drug safety signal detection. Int J Clin Pharm., 37(1), 94-104.
  • [23] Koh H.C., Tan G. 2005. Data mining applications in healthcare. Journal of Healthcare Information Management, 19(2), 64-72.
  • [24] Hamuro Y., Katoh N., Matsuda Y., Yada K. 1998. Mining pharmacy data helps to make profits. Data Mining and Knowledge Discovery, 2, 391–398.
  • [25] Jensen P.B., Jensen L.J., Brunak S. 2012. Mining electronic health records: towards better research applications and clinical care. Nat Genet., 13, 395–405.
  • [26] Bereznicki B.J., Peterson G.M., Jackson S.L., Walters H., Fitzmaurice K., Gee P. 2008. Pharmacist-initiated general practitioner referral of patients with suboptimal asthma management. Pharmacy World & Science, 30: 869–875.
  • [27] Khader N., Lashier A., Yoon S.W. 2016. Pharmacy robotic dispensing and planogram analysis using association rule mining with prescription data, Expert Systems with Applications, 57, 296-310.
  • [28] Chapman P., Clinton J., Kerber R., Khabaza T., Reinartz T., Shearer C., Wirth R. CRISP-DM 1.0 Step-by-step data mining guide. CRISP-DM Consortium. 2000. http://the-modeling-agency.com/crisp-dm.pdf.
  • [29] Agrawal R., Imielinski T., Swami A. 1993. Mining association rules between sets of items in large databases. In: Proceedings of the ACM SIGMOD international conference on management of data, Washington, DC.
  • [30] Agrawal R., Srikant R. 1994. Fast algorithms for mining association rules. In: Proceedings of the 20th VLDB Conference, Santiago, Chile.
  • [31] Doddi S., Marathe A., Ravi S.S., Torney D.C. 2001. Discovery of association rules in medical data. Med Inform Internet Med., 26, 25–33.
  • [32] Nguyen P.A., Syed-Abdul S., Iqbal U., Hsu M.H., Huang C.L., Li H.C., Clinciu D.L., Jian W.S., Li Y.C. 2013. A probabilistic model for reducing medication errors. PLoS One, 8(12), e8240.
  • [33] Kim J.W. 2017. Construction and evaluation of structured association map for visual exploration of association rules. Expert systems with applications, 74, 70-81.
  • [34] Huang Y., Britton J., Hubbard R., Lewis S. 2013. Who receives prescriptions for smoking cessation medications? An association rule mining analysis using a large primary care database. Tob Control. 22(4), 274-279.
  • [35] World Health Organization Collaborating Center for Drug Statistics Methodology. Guidelines for ATC classification and DDD assignment. WHOCC. 2013. http://www.whocc.no/filearchive/publications/1_2013guidelines.pdf
  • [36] Rønnig M. 2001. Coding and classification in drug statistics—From national to global application. Nor J Epidemiol, 11, 37–40.
  • [37] Linoff G.S., Berry M.J. 2011. Data mining techniques: For marketing, sales and customer relationship management (3rd ed.) Indianapolis, Wiley Publishing Inc.
  • [38] Kalaichelvi A., Malini P.H., 2011. Application of fuzzy soft sets to investment decision making problem. Internal Journal of Mathematical Sciences and Applications, 1(3), 1583-1586.
  • [39] Yuksel S., Dizman T., Yildizdan G., Sert U. 2013. Application of soft sets to diagnose the prostate cancer risk. Journal of Inequalities and Applications, 229.
  • [40] Özgür N.Y., Taş N. 2015. A Note On "Application of Fuzzy Soft Sets to Investment Decision Making Problem". Journal of New Theory, 1(7), 1-10.
  • [41] Dash S.R., Dehuri S., Sahoo U.K. 2013. Interactions and Applications of Fuzzy, Rough, and Soft Set in Data Mining, International Journal of Fuzzy System Applications, 3(3), 37-50.
  • [42] Feng F., Cho J., Pedrycz W., Fuzita H., Herawan T. 2016. Soft set based association rule mining, Knowledge-Based Systems, Volume 111, 268-282.
  • [43] Kavakiotis I., Tsave O., Salifoglou A., Maglaveras N., Vlahavas I., Chouvarda I. 2017. Machine learning and data mining methods in diabetes research. Computational and Structural Biotechnology Journal, 15, 104-116.
  • [44] Blattberg R.C., Kim B.D., Neslin, S.A. 2008 Database Marketing: Analyzing and Managing Customers. New York, Springer.
  • [45] Borg I., Groenen P. 2005. Modern Multi-dimensional scaling theory and applications. Berlin: Springer.
  • [46] Çil I. 2012. Consumption universes based supermarket layout through association rule mining and multidimensional scaling. Expert Systems with Applications, 39(10), 8611–8625.
  • [47] Jaworska N., Chupetlovska-Anastasova A. 2009. A review of multidimentional scaling (MDS) and its utility in various psychological domains. Tutorials in Quantitative Methods for Psychology, 5(1), 1–10.
  • [48] Kruskal J.B. 1964. Multidimensional scaling by optimizing goodness of fit to a nonmetric hypothesis. Psychometrika, 29, 1–27.
  • [49] Kruskal J.B., Wish M. Multidimensional scaling. Sage University Paper series on Quantitative Applications in the Social Sciences, number 07-011. Newbury Park, CA: Sage Publications; 1978.
  • [50] Turkish Medicines and Medical Device Agency. E-prescription drug list. TMMDA. 2014. http://www.titck.gov.tr/DisplayDynamicModule.aspx?mId=a/0Tp/ovYIU.
  • [51] SPSS Clementine 11.1. User’s Guide http://home.kku.ac.th/wichuda/DMining/ClementineUsersGuide_11.1.pdf
  • [52] Borges A. 2003. Toward a new supermarket layout: from industrial categories to one stop shopping organization through a data mining approach. In: Proceedings of the 2003 society for marketing advances annual symposium on retail patronage and strategy, Montreal, November, 4–5.
  • [53] Mollahaliloglu S., Alkan A., Donertas B., Ozgulcu S, Akıcı A. 2013. Prescribing Practices of Physicians at Different Health Care Institutions. Saudi Pharmaceutical Journal, 21(3), 281-291.
There are 53 citations in total.

Details

Journal Section Articles
Authors

Zeynep Ceylan This is me

Seniye Ümit Fırat

Publication Date September 19, 2017
Published in Issue Year 2017 Volume: 21 Issue: 3

Cite

APA Ceylan, Z., & Fırat, S. Ü. (2017). A New Drug-Shelf Arrangement for Reducing Medication Errors using Data Mining: A Case Study. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 21(3), 774-781. https://doi.org/10.19113/sdufbed.14205
AMA Ceylan Z, Fırat SÜ. A New Drug-Shelf Arrangement for Reducing Medication Errors using Data Mining: A Case Study. J. Nat. Appl. Sci. December 2017;21(3):774-781. doi:10.19113/sdufbed.14205
Chicago Ceylan, Zeynep, and Seniye Ümit Fırat. “A New Drug-Shelf Arrangement for Reducing Medication Errors Using Data Mining: A Case Study”. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi 21, no. 3 (December 2017): 774-81. https://doi.org/10.19113/sdufbed.14205.
EndNote Ceylan Z, Fırat SÜ (December 1, 2017) A New Drug-Shelf Arrangement for Reducing Medication Errors using Data Mining: A Case Study. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi 21 3 774–781.
IEEE Z. Ceylan and S. Ü. Fırat, “A New Drug-Shelf Arrangement for Reducing Medication Errors using Data Mining: A Case Study”, J. Nat. Appl. Sci., vol. 21, no. 3, pp. 774–781, 2017, doi: 10.19113/sdufbed.14205.
ISNAD Ceylan, Zeynep - Fırat, Seniye Ümit. “A New Drug-Shelf Arrangement for Reducing Medication Errors Using Data Mining: A Case Study”. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi 21/3 (December 2017), 774-781. https://doi.org/10.19113/sdufbed.14205.
JAMA Ceylan Z, Fırat SÜ. A New Drug-Shelf Arrangement for Reducing Medication Errors using Data Mining: A Case Study. J. Nat. Appl. Sci. 2017;21:774–781.
MLA Ceylan, Zeynep and Seniye Ümit Fırat. “A New Drug-Shelf Arrangement for Reducing Medication Errors Using Data Mining: A Case Study”. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi, vol. 21, no. 3, 2017, pp. 774-81, doi:10.19113/sdufbed.14205.
Vancouver Ceylan Z, Fırat SÜ. A New Drug-Shelf Arrangement for Reducing Medication Errors using Data Mining: A Case Study. J. Nat. Appl. Sci. 2017;21(3):774-81.

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