Synthesis and Analysis of Antimicrobial Properties of Macrocyclic Compounds Containing Thiophene and Furan Rings

Year 2019, Volume: 23 Issue: 1, 170 - 174, 01.04.2019

Hafize Özcan

https://doi.org/10.19113/sdufenbed.470761

Cited By: 1

Abstract

Macrocylic
compounds  are functional compounds which
have  different applications in many
fields of chemistry. In this work, new macrocyclic ethers containing furan and
thiophene rings were obtained in good yields using different methods. In addition, antimicrobial activities of these
compounds against Escherichia coli
ATCC 25922, Salmonella thphimurium
ATCC 14028, Staphylococcus aureus ATCC 25923, Bacillus cereus ATCC 11778, and Listeria
monocytogenes ATCC 19115 bacteria and antifungal activity on Candida albicans ATCC 10231 were
investigated. It has
been found that the synthesized compounds show a moderate effect against some
bacterial species.    

Keywords

Crown ether, Macrocyclic, Antimicrobial, Furan, Thiophene

Tiyofen ve Furan Halkaları İçeren Makrosiklik Bileşiklerinin Sentezleri ve Antimikrobiyal Özelliklerinin İncelenmesi

Abstract

Makrosiklik
bileşikler, kimyanın pek çok alanında farklı uygulamalara sahip işlevsel
bileşiklerdir. Bu çalışmada da furan ve tiyofen heterosiklik halkalarını içeren
yeni makrosiklik eterler farklı reaksiyon şartları denenerek, en verimli
şekilde sentezlenmiştir. Ayrıca sentezlenen bu bileşiklerin Escherichia coli ATCC 25922, Salmonella thphimurium ATCC 14028, Staphylococcus aureus ATCC 25923, Bacillus cereus ATCC 11778 ve Listeria monocytogenes ATCC 19115
bakterilerine karşı antimikrobiyal aktiviteleri, Candida albicans ATCC 10231 mayaları üzerinde antifungal
aktiviteleri incelenmiştir. Sentezlenen bileşiklerin bazı bakteri türlerine
karşı ılımlı etki gösterdiği bulunmuştur.

Keywords

Taç eter, Makrosiklik, Antimikrobiyal, Furan, Tiyofen

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