Antibacterial Effect of Luteolin Obtained from Terebinth (Pistacia terebinthus L.) Bark Extracts

Yıl 2024, , 209 - 213, 28.08.2024

Suna Kızılyıldırım

https://doi.org/10.22312/sdusbed.1511179

Öz

Phytochemicals are chemical compounds derived from therapeutic plants that have a variety of pharmacological effects. In particular, flavonoids are the most effective phytochemical components with various biological activities and pharmacological effects. Luteolin is an important flavonoid found naturally in many plant species. This study aimed to investigate the antibacterial effect of luteolin flavonoid obtained from terebinth (Pistacia terebinthus L.) bark extracts.

In the study, MIC values of luteolin against reference strains Staphylococcus aureus ATCC 29213, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Streptococcus agalactiae ATCC 12401, Enterococcus feacalis ATCC 29212 were investigated by broth microdilution method.

As a result of the study, it was determined that luteolin showed antibacterial activity against all tested strains.

Anahtar Kelimeler

Flavonoid, Luteolin, Antibacterial activity

Menengiç (Pistacia terebinthus L.) Kabuk Ekstrelerinden Elde Edilen Luteolinin Antibakteriyel Etkisi

Öz

Fitokimyasallar, çeşitli farmakolojik etkilere sahip, tedavi edici bitkilerden elde edilen kimyasal bileşiklerdir. Özellikle flavonoidler çeşitli biyolojik aktivitelere ve farmakolojik etkilere sahip en etkili bir fitokimyasal bileşendir. Luteolin birçok bitki türünde doğal olarak bulunan önemli bir flavonoiddir. Bu çalışmada menengiç (Pistacia terebinthus L.) kabuk ekstrelerinden elde edilen luteolin flavonoidinin antibakteriyel etkisinin araştırılması amaçlanmıştır.
Çalışmada, luteolinin Staphylococcus aureus ATCC 29213, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Streptococcus agalactiae ATCC 12401, Enterococcus feacalis ATCC 29212 referans suşlarına karşı MİK değerleri, broth mikrodilüsyon yöntemi ile araştırılmıştır.
Çalışma sonucunda, luteolinin test edilen tüm suşlara karşı antibakteriyel aktivite gösterdiği tespit edilmiştir.

Anahtar Kelimeler

Flavonoid, Luteolin, Antibakteriyel aktivite

Etik Beyan

-

Destekleyen Kurum

-

Teşekkür

Çalışmada luteolin izolasyonunu sağlayan, Prof. Dr. Ahmet ÇAKIR ve Dr. Öğr. Üyesi Mehmet AKYÜZ’e katkılarından dolayı teşekkür ederim.

Kaynakça

• [1] Banica, T., Belinschi, S. T., Capitaine, M., Collins, B. 2011. Free Bessel Laws. Canadian Journal of Maiyo, Z., Ngure, R., Matasyoh, J., Chepkorir, R., 2010. Phytochemical Constituents and antimicrobial activity of leaf extracts of three Amaranthus plant species. Afr. J. Biotechnol, 9(21), 3178-3182.
• [2] Erfan, A. M., Marouf, S., 2019. Cinnamon oil downregulates virulence genes of poultry respiratory bacterial agents and revealed significant bacterial inhibition: An in vitro perspective. Vet. World, 12 (11), 1707-1715.
• [3] Matasyoh, J., Maiyo, Z., Ngure, R., Chepkorir, R. 2009. Chemical composition and antimicrobial activity of the essential oil of Coriandrum sativum. Food Chem. 113(2), 526–529.
• [4] Souza, E. L. D., Lima, E. D. O., Freire, K. L., Sousa, C. D. 2005. Inhibitory action of some essential oils and phytochemicals on the growth of various moulds isolated from foods. Brazil. Arch Biol. Tech., 48(2), 245–250.
• [5] Özcan, M. M., Al Juhaimi, F., Uslu, N., Ahmed, I. A. M., Babiker, E. E., Osman, M. A., Gassem, M. A., Alqah, H. A. S., & Ghafoor, K. 2020. Effect of sonication process of terebinth (Pistacia terebinthus L.) fruits on antioxidant activity, phenolic compounds, fatty acids and tocopherol contents. Journal of Food Science and Technology, 57, 2017-25.
• [6] Topçu, G., Ay, M., Bilici, A., Sarıkürkcü, C., Öztürk, M., & Ulubelen, A. 2007. A new flavone from antioxidant extracts of Pistacia terebinthus. Food Chemistry, 103(3), 816-822.
• [7] Naghmachi, M., Raissi, A., Baziyar, P., Homayoonfar, F., Amirmahani, F., & Danaei, M. 2022. Green synthesis of silver nanoparticles (AgNPs) by Pistacia terebinthus extract: Comprehensive evaluation of antimicrobial, antioxidant and anticancer effects. Biochemical and Biophysical Research Communications, 608, 163-169.
• [8] Guo, Y., Liu, Y., Zhang, Z., Chen, M., Zhang, D., Tian, C., Liu, M., & Jiang, G. 2020. The antibacterial activity and mechanism of action of luteolin against Trueperella pyogenes. Infection and drug resistance, 13, 1697-1711.
• [9] Bravo, L. 1998. Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutrition reviews, 56(11), 317-333.
• [10] Lin, Y., Shi, R., Wang, X., & Shen, H. M. 2008. Luteolin, a flavonoid with potential for cancer prevention and therapy. Current cancer drug targets, 8(7), 634-646.
• [11] Nabavi, S. F., Braidy, N, Gortzi, O., Sobarzo-Sanchez, E., Daglia, M., SkalickaWoźniak, K., Nabavi, S. M. 2015. Luteolin as an anti-inflammatory and neuroprotective agent: a brief review, Brain Res. Bull. 119, 1–11,
• [12] Qian, W., Liu, M., Fu, Y., Zhang, J., Liu, W., Li, J., and et al. 2020. Antimicrobial mechanism of luteolin against Staphylococcus aureus and Listeria monocytogenes and its antibiofilm properties. Microbial pathogenesis, 142, 104056.
• [13] Kısa, A., Akyüz, M., Çoğun, H. Y., Kordali, Ş., Bozhüyük, A. U., Tezel, B., et al. 2018. Effects of Olea europaea L. leaf metabolites on the tilapia (Oreochromis niloticus) and three stored pests, Sitophilus granarius, Tribolium confusum and Acanthoscelides obtectus. Records of Natural Products, 12(3), 201.
• [14] Kızılyıldırım, S., Kandemir, T., Kendir, G., Muhammed, M. T., Köroğlu, A., Köksal, F., & Ozogul, F. 2024. The antibacterial effect mechanisms of Laurus nobilis extracts on carbapenem-resistant Acinetobacter baumanii isolates. Food Bioscience, 104011.
• [15] Kavak, D. D., Altıok, E., Bayraktar, O., & Ülkü, S. 2010. Pistacia terebinthus extract: As a potential antioxidant, antimicrobial and possible β-glucuronidase inhibitor. Journal of Molecular Catalysis B: Enzymatic, 64, 167-171.
• [16] Fidan, M. S., Baltacı, C., Öz, M., and Akar, Z. 2023. Chemical composition of Pistacia terebinthus L. and its phytochemical and biological properties. BioResources 18(4), 6862-6881.
• [17] Kaya, M, Khadem, S, Cakmak, Y. S, Mujtaba, M, Ilk, S, Akyuz, L, Salaberria, A. M., et al. 2018. Antioxidative and antimicrobial edible chitosan films blended with stem, leaf and seed extracts of Pistacia terebinthus for active food packaging. RSC Adv., 8, 3941-3950.
• [18] Xi, M., Hou, Y., Wang, R., Ji, M., Cai, Y., Ao, J., Shen, H., Li, M., Wang, J., Luo, A. 2022. Potential application of luteolin as an active antibacterial composition in the development of hand sanitizer products. Molecules. 27(21), 7342.
• [19] Xiao, C., Xia, M. L., Wang, J., Zhou, X.R., Lou, Y. Y., Tang, L .H., Qian, L.B. 2019. Luteolin attenuates cardiac ischemia/reperfusion injury in diabetic rats by modulating Nrf2 antioxidative function. Oxidative Med. Cell Longev. 2719252.
• [20] Wang, Q., Xie, M. 2010. Antibacterial activity and mechanism of luteolin on Staphylococcus aureus. Wei Sheng Wu Xue Bao Acta microbiologica Sinica , 50(9),180-4
• [21] Lv, P.C., Li, H.Q, Xue, J.Y., Shi, L., Zhu, H.L. 2009. Synthesis and biological evaluation of novel luteolin derivatives as antibacterial agents. Eur J Med Chem. 44(2), 908-914.