Erken Çocukluk Dönemde Anormal Bağışıklık: Alerji ve Yüksek Oranda Antinükleer Antikorların Birlikte Görülmesi

Abstract

Amaç: Alerji ve otoantikor üretimi, aşırı duyarlılık nedeniyle ortaya çıkan bağışıklık sistemi ile ilgili iki anormal durumdur. Erken çocukluk döneminde başlayan alerjilerle otoantikorların ilişkilendirilip ilişkilendirilemeyeceği henüz netlik kazanamamıştır. Bu çalışma, üç yaş altındaki alerjik çocuklarda antinükleer antikorların (ANA) varlığını değerlendirmeyi amaçlamaktadır. Gereç ve yöntem: Alerjik çocuklar (yaş < 3 yıl; n=40), klinik ve laboratuvar bulgularına dayanarak bir uzman tarafından teşhis edilmiştir. ANA düzeyleri, ticari bir ELISA testi ile ölçülmüştür. Demografik veriler, toplam ve spesifik (yumurta, süt) IgE düzeyleri ile kan eozinofil yüzdeleri hastane kayıtlarından elde edilmiştir. Kontrol grubu, alerjisi olmayan sağlıklı bireylerden oluşturulmuştur. Bulgular: Sağlıklı kontrol grubunda 8 birey (8/40, %20) ANA pozitif çıkarken, 17 alerjik çocuk (17/40, %42.5) ANA pozitif bulunmuştur (p<0.05). ANA pozitifliği, yumurta alerjisi olan 8 çocukta, süt alerjisi olan 2 çocukta, hem yumurta hem de süt alerjisi olan 4 çocukta ve nedeni bilinmeyen alerjisi olan 3 çocukta gözlemlenmiştir. ANA pozitifliği ile IgE düzeyleri ve eozinofil yüzdeleri arasında anlamlı bir ilişki bulunmamıştır (p>0.05). Ayrıca, alerjik çocuklarda ANA düzeyleri ile kaşıntı veya egzama varlığı arasında bir ilişki tespit edilmemiştir. Sonuç: Bu çalışma, alerji ile ANA pozitifliği arasındaki ilişkinin erken çocukluk döneminde başladığını göstermekte ve bu iki durumun potansiyel etkileşimleri üzerine yapılacak gelecekteki araştırmaların bu kritik döneme odaklanması gerektiğini önermektedir. Ayrıca, her iki bağışıklık anomalisinin benzer mekanizmalarla düzenlenip düzenlenmediğinin belirlenmesi amacıyla daha fazla araştırma yapılması gerektiği sonucuna varılmaktadır.

Keywords

• Alerji
• Otoantikor
• ANA
• Çocuklar

Coexistence of Allergy and Antinuclear Antibody in Early Childhood

Abstract

Background: Allergy and autoantibody production are two abnormal conditions of the immune system, resulting from hypersensitivity. It remains unclear whether autoantibodies are also present in association with allergies that begin during early childhood. This study aims to evaluate the presence of antinuclear antibodies (ANA) in allergic children under the age of three. Methods: Allergic children (age < 3 years; n=40) were diagnosed by a specialist based on clinical and laboratory findings. ANA levels were measured using a commercial ELISA test. Demographic data, total and specific (egg, milk) IgE levels, and blood eosinophil percentages were obtained from hospital records. The control group was composed of healthy individuals without allergies. Results: In the healthy control group, 8 individuals (8/40, 20%) were ANA positive, while 17 allergic children (17/40, 42.5%) tested positive for ANA (p<0.05). ANA positivity was observed in 8 children with an egg allergy, 2 children with a milk allergy, 4 children with both egg and milk allergies, and 3 children with an unknown allergy cause. No significant correlation was found between ANA positivity, IgE levels, and eosinophil percentages (p>0.05). Additionally, no relationship was found between ANA levels and the presence of itching or eczema in allergic children. Conclusions: This study suggests that the relationship between allergies and ANA positivity begins in early childhood and recommends that future studies on the potential interactions of these two conditions should focus on this critical period. Additionally, further research is needed to determine whether both immune anomalies are regulated by similar mechanisms.

Keywords

• Allergy
• Autoantibody
• ANA
• Children.

Supporting Institution

None

Ethical Statement

Ethical approval for the study was obtained from the Scientific Research and Publication Ethics Committee of İnönü University (protocol no 2023/4721).

Thanks

None

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